Neuroplasticity in the context of motor rehabilitation after stroke

Dimyan, Michael A.; Cohen, Leonardo G.

doi:10.1038/nrneurol.2010.200

Cited by 564 publications

(405 citation statements)

References 176 publications

(151 reference statements)

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“…Approximately one third of stroke survivors experience disability; motor impairments are recognised as a major contributor (Dimyan & Cohen, 2011). This Wise, SiFuentes, & Milliken, 1996;Toni, Krams, Turner, & Passingham, 1998;Ziemann, Muellbacher, Hallett, & Cohen, 2001).…”

Section: Introductionmentioning

confidence: 99%

A double-blinded randomised controlled trial exploring the effect of anodal transcranial direct current stimulation and uni-lateral robot therapy for the impaired upper limb in sub-acute and chronic stroke

Triccas

Burridge

Hughes

et al. 2015

NRE

111

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Abstract. BACKGROUND:Neurorehabilitation technologies such as robot therapy (RT) and transcranial Direct Current Stimulation (tDCS) can promote upper limb (UL) motor recovery after stroke. OBJECTIVE: To explore the effect of anodal tDCS with uni-lateral and three-dimensional RT for the impaired UL in people with sub-acute and chronic stroke. METHODS: A pilot randomised controlled trial was conducted. Stroke participants had 18 one-hour sessions of RT (Armeo ® Spring) over eight weeks during which they received 20 minutes of either real tDCS or sham tDCS during each session. The primary outcome measure was the Fugl-Meyer assessment (FMA) for UL impairments and secondary were: UL function, activities and stroke impact collected at baseline, post-intervention and three-month follow-up. RESULTS: 22 participants (12 sub-acute and 10 chronic) completed the trial. No significant difference was found in FMA between the real and sham tDCS groups at post-intervention and follow-up (p = 0.123). A significant 'time' x 'stage of stroke' was found for FMA (p = 0.016). A higher percentage improvement was noted in UL function, activities and stroke impact in people with sub-acute compared to chronic stroke. CONCLUSIONS: Adding tDCS did not result in an additional effect on UL impairment in stroke. RT may be of more benefit in the sub-acute than chronic phase.

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Section: Introductionmentioning

confidence: 99%

A double-blinded randomised controlled trial exploring the effect of anodal transcranial direct current stimulation and uni-lateral robot therapy for the impaired upper limb in sub-acute and chronic stroke

Triccas

Burridge

Hughes

et al. 2015

NRE

111

View full text Add to dashboard Cite

show abstract

“…Approximately 85 percent of patients with stroke do not regain upper-limb function and remain dependent on caregivers [2][3], with motor impairments accounting for most poststroke disability [4]. Loss of upper-limb function is a major cause of poor perception of well-being following stroke [5].…”

Section: Introductionmentioning

confidence: 99%

Participant perceptions of use of CyWee Z as adjunct to rehabilitation of upper-limb function following stroke

Hale

Satherley

McMillan

et al. 2012

JRRD

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Abstract-This article reports on the perceptions of 14 adults with chronic stroke who participated in a pilot study to determine the utility, acceptability, and potential efficacy of using an adapted CyWee Z handheld game controller to play a variety of computer games aimed at improving upper-limb function. Four qualitative in-depth interviews and two focus groups explored participant perceptions. Data were thematically analyzed with the general inductive approach. Participants enjoyed playing the computer games with the technology. The perceived benefits included improved upper-limb function, concentration, and balance; however, six participants reported shoulder and/or arm pain or discomfort, which presented while they were engaged in play but appeared to ease during rest. Participants suggested changes to the games and provided opinions on the use of computer games in rehabilitation. Using an adapted CyWee Z controller and computer games in upper-limb rehabilitation for people with chronic stroke is an acceptable and potentially beneficial adjunct to rehabilitation. The development of shoulder pain was a negative side effect for some participants and requires further investigation.

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“…Recent rehabilitation approaches to facilitate motor system recovery include transcranial magnetic low frequency stimulation of injured cortex paired with motor tasks and brain-computer/machine-interface (BMI) rehabilitation [71]. Such applications have been used in humans, rats and non-human primates.…”

Section: Brain-computer/machine-interface (Bmi) Rehabilitation In Motmentioning

confidence: 99%

Visualizing Recovery of Cognitive Function in Stroke

Hebb¹,

Brandman²,

Shankar³

et al. 2013

JBBS

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Hippocrates (460-377 BC) first described stroke over 2400 years ago. Stroke is the 4 th leading cause of death in Canada (3 rd in the USA) and the primary cause of permanent motor and cognitive disability. The majority of strokes are ischemic. The extent of cerebral dysfunction and thus the severity of stroke are based on the location, severity and duration of ischemia. Stroke management and prognosis encompass early recognition of the onset of stroke and post-stroke determination of the extent of brain injury aided by clinical stroke scores and diffusion-weighted imaging. Cognitive domains most likely to be affected following stroke are memory, orientation, language, attention and executive function. While the vast majority of functional recovery occurs within the first 3 months post-stroke, the neural mechanisms promoting recovery are not well understood. Investigations into the neural plasticity of brain areas after a lesion demonstrate that the adult brain can be shaped by environmental inputs, such as rehabilitation techniques. Many rehabilitation techniques are actively being pursued, including brain-computer interfaces providing sophisticated methods for detecting rehabilitation-associated changes in cerebral physiology. The success of such strategies visualized with functional magnetic resonance imaging and positron emission tomography may provide an objective complement to clinical evaluations.

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Neuroplasticity in the context of motor rehabilitation after stroke

Cited by 564 publications

References 176 publications

A double-blinded randomised controlled trial exploring the effect of anodal transcranial direct current stimulation and uni-lateral robot therapy for the impaired upper limb in sub-acute and chronic stroke

A double-blinded randomised controlled trial exploring the effect of anodal transcranial direct current stimulation and uni-lateral robot therapy for the impaired upper limb in sub-acute and chronic stroke

Participant perceptions of use of CyWee Z as adjunct to rehabilitation of upper-limb function following stroke

Visualizing Recovery of Cognitive Function in Stroke

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