Neuroprotective Activity of Fractional Flower Extracts of Mirabilis Jalapa Against Aluminium Hydrochloride Induced Neurotoxicity in Male Wister Rats

Abstract

Objective: The major objective of this present study was to evaluate the neuroprotective effect of fractional flower extracts (acetone, petroleum ether, methanol and aqueous) of Mirabilis jalapa (MJ) against aluminium hydrochloride-induced neurotoxicity in male wister rats. Methods:From the different fractional flower extracts of Mirabilis jalapa (MJ), two doses (250 and 500 mg/kg body weight) of each extract was initially selected and administered per orally 30 min prior to aluminium hydrochloride administration to the different animal groups once a day for a period of 45 d. Rat serum was collected from different animal groups on 1 st , 15 th , 30 th and 45 th Results: On the 9 days for estimation of marker enzymes, where a reduction in marker was observed. Animal was sacrificed by decapitation and the whole brain of rats was analyzed to estimate the levels of nitrite, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (DOS), catalase, reduced glutathione and acetylcholinesterase (AchE).th Conclusion: This result is indicating evidence for Mirabilis jalapa had a significant neuroprotective effect on aluminium hydrochloride-induced neurotoxicity and also supports by histopathological studies.day the Wister rats were sacrificed and cerebral cortex was removed. One-half of the cerebral cortex samples from different groups of Aluminium hydrochloride treated rats were stored in FAM mixture (40% formaldehyde, acetic acid and methanol in the ratio of 1:1:8) for histological analysis. From the study confirmed that dose of 250 and 500 mg/kg bwt of methanolic extract of MJ significantly (p˂0.001) increases the reduced glutathione, superoxide dismutase and catalase level, whereas petroleum ether, acetone and aqueous fractional flower extracts of MJ significantly (p˂0.01) decreases nitrite, TBARS and AchE levels of aluminium hydrochloride treated groups.

Hydroalcoholic Extract of Swertia Chirata and Swertia Cordata Attenuates Hypoxia-Mediated Memory Dysfunction by Improving Neuronal Survival in Wistar Rats

“…Previous reports suggest that neurodegeneration and neuronal damage are associated with impaired memory function in rodents [5,10], besides indicating enhanced oxidative stress as an important contributing factor for neurodegeneration [5,10]. Neuroprotective potential of herbal interventions has been reported to be associated with the improved behavior functions [5,10,[29][30][31][32][33]. Our results are in line with these findings, and we have demonstrated that treating hypoxic animals with plant extract improved neuronal morphology and rescued them from degenerative changes.…”

Neuroprotective and Cognitive Enhancing Effect of Methanolic Morus Alba Leaf Fraction in U87mg Cell Lines and Experimental Rat Model

“…A 10% (w/v) homogenate of brain samples (0.1 M sodium phosphate buffer, pH 7.4) were prepared using homogenizer and then centrifuged at 4000 rpm for 10 min at 4°C. The supernatant homogenate was used to measure, total protein content (Spinreact), and the activities of CAT, SOD, GSH, and LPO based on the standard methods [21][22][23][24].…”