Neuroprotective approaches to halt Parkinson's disease progression

Sola, Piyong; Krishnamurthy, Praveen Thaggikuppe; Kumari, Mamta; Byran, Gowramma; Gangadharappa, H.V.; Garikapati, Kusuma Kumari

doi:10.1016/j.neuint.2022.105380

Cited by 13 publications

(8 citation statements)

References 287 publications

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“…Efforts have therefore focussed on using combinations of drugs to reduce the required doses while reducing associated side effects (Baker et al, 2009;Radhakrishnan and Goyal, 2018;Moretti, 2019;Sola et al, 2022). The search for new potential therapies therefore focuses on finding new targets and drugs that will provide a slowing down of disease progression and low side effects, and probiotics are good candidates for effective intervention in the treatment of PD, considering their anti-inflammatory and neuroprotective effects.…”

Section: Conclusion: Is Supplementation With Probiotics a New Therape...mentioning

confidence: 99%

“…Additionally, current treatments are associated with mild side effects, such as nausea, vomiting, and low blood pressure and more severe side effects, such as behavioral impediments, generation of toxic metabolites and paranoia ( Paul and Borah, 2016 ). Efforts have therefore focussed on using combinations of drugs to reduce the required doses while reducing associated side effects ( Baker et al, 2009 ; Radhakrishnan and Goyal, 2018 ; Moretti, 2019 ; Sola et al, 2022 ). The search for new potential therapies therefore focuses on finding new targets and drugs that will provide a slowing down of disease progression and low side effects, and probiotics are good candidates for effective intervention in the treatment of PD, considering their anti-inflammatory and neuroprotective effects.…”

Section: Conclusion: Is Supplementation With Probiotics a New Therape...mentioning

confidence: 99%

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Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson’s disease model

Sancandi¹,

De²,

Cypaite³

et al. 2023

Front. Aging Neurosci.

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An increasing number of studies in recent years have focused on the role that the gut may play in Parkinson’s Disease (PD) pathogenesis, suggesting that the maintenance of a healthy gut may lead to potential treatments of the disease. The health of microbiota has been shown to be directly associated with parameters that play a potential role in PD including gut barrier integrity, immunity, function, metabolism and the correct functioning of the gut-brain axis. The gut microbiota (GM) may therefore be employed as valuable indicators for early diagnosis of PD and potential targets for preventing or treating PD symptoms. Preserving the gut homeostasis using probiotics may therefore lead to a promising treatment strategy due to their known benefits in improving constipation, motor impairments, inflammation, and neurodegeneration. However, the mechanisms underlying the effects of probiotics in PD are yet to be clarified. In this project, we have tested the efficacy of an oral probiotic suspension, Symprove™, on an established animal model of PD. Symprove™, unlike many commercially available probiotics, has been shown to be resistant to gastric acidity, improve symptoms in gastrointestinal diseases and improve gut integrity in an in vitro PD model. In this study, we used an early-stage PD rat model to determine the effect of Symprove™ on neurodegeneration and neuroinflammation in the brain and on plasma cytokine levels, GM composition and short chain fatty acid (SCFA) release. Symprove™ was shown to significantly influence both the gut and brain of the PD model. It preserved the gut integrity in the PD model, reduced plasma inflammatory markers and changed microbiota composition. The treatment also prevented the reduction in SCFAs and striatal inflammation and prevented tyrosine hydroxylase (TH)-positive cell loss by 17% compared to that observed in animals treated with placebo. We conclude that Symprove™ treatment may have a positive influence on the symptomology of early-stage PD with obvious implications for the improvement of gut integrity and possibly delaying/preventing the onset of neuroinflammation and neurodegeneration in human PD patients.

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Section: Conclusion: Is Supplementation With Probiotics a New Therape...mentioning

confidence: 99%

Section: Conclusion: Is Supplementation With Probiotics a New Therape...mentioning

confidence: 99%

Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson’s disease model

Sancandi¹,

De²,

Cypaite³

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

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“…Parkinson’s disease (PD) stands as a prevalent neurodegenerative disorder ( 1 ) with treatment challenges that have yet to demonstrate the capability to halt long-term disease progression ( 2 ). Currently, pharmaceutical therapy remains the primary approach for managing PD ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Acupuncture therapy for Parkinson’s disease: a case report demonstrating symptomatic improvement without medication

Lei,

Liu,

Leong

et al. 2024

Front. Neurol.

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BackgroundParkinson’s disease (PD) often necessitates immediate medical intervention following diagnosis. In recent years, there has been a noticeable increase in clinical investigations assessing the efficacy of acupuncture in PD, with many studies reporting positive outcomes. Ethical guidelines commonly endorse pharmaceutical therapies for PD, leading ongoing research to combine acupuncture with standard drug-based treatments. At present, there is a conspicuous absence of dedicated clinical research exclusively examining the independent impact of acupuncture on PD treatment.CaseIn a clinical observation, we documented a case involving a 75-year-old male displaying progressive, characteristic PD symptoms, including evident limb tremors, rigidity, bradykinesia, fatigue, and additional non-motor symptoms. The patient received a confirmed diagnosis of PD. Due to the refusal of the patient to take medication, we exclusively administered acupuncture therapy. The outcomes indicated a noteworthy enhancement in the clinical symptoms of the patient solely through acupuncture intervention.ConclusionThis case affirms that using acupuncture in isolation significantly improved both the motor and non-motor symptoms in the patient. Acupuncture could potentially serve as an alternative therapy for patients who decline or are intolerant to anti-Parkinson drugs. However, further studies are needed to assess its long-term efficacy. This case report obtained approval from the Ethics Committee of the First Affiliated Hospital of Guangzhou University of Chinese Medicine (Ethics number: K-2023-127).

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“…In 2016, the number of PD patients worldwide has reached 61 million (Dorsey et al, 2018 ). Although many treatments have been carried out to treat PD, none of them, alone or in combination, are capable of halting the disease progression in the long run (Sola et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Qualitative and quantitative meta-analysis of acupuncture effects on the motor function of Parkinson's disease patients

Lei,

Fan,

Liu

et al. 2023

Front. Neurosci.

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ObjectiveTo explore the association between acupuncture sessions and its effects on the motor function of Parkinson's Disease (PD).MethodsEight databases and two clinical trials registries were searched from inception to August 2022. Randomized controlled trials (RCTs) that compared acupuncture with sham acupuncture, or antiparkinsonian drugs, were included. After qualitative meta-analysis, a non-linear meta regression approach with restricted cubic spline was used to investigate the dose-response relationship between acupuncture sessions and their efficacy on the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) score. Subgroup meta-analysis was performed of the included studies according to the weekly acupuncture frequency. And finally, the included studies containing the determination of intermediate efficacy were compared.ResultsOf the 268 citations screened, 16 studies (462 patients of PD) were included. The qualitative meta-analysis showed that the acupuncture group had better effect on UPDRS-III scores than the control group. And the quantitative meta-analysis suggested that acupuncture dose was correlated with the reduction of UPDRS-III score in PD patients with motor symptoms. In subgroup analysis, on the one hand, when the frequency of acupuncture was no more than 3 times a week, with the increase of acupuncture session, the changes of UPDRS-III score decreased and then increased (P = 0.000). On the other hand, when acupuncture for more than 3 times a week and the dose of acupuncture treatment was <60 times, the changes of UPDRS-III score increased with the increase of acupuncture dose, but the score stopped to decrease if the dose continued to increase (P = 0.020). The comparative analysis of two quantitative RCTs found that the score improvement was more significant at the higher weekly acupuncture frequency.InterpretationThis study found that when treating PD patients with motor symptoms, acupuncture treatment may need to reach a certain dose to obtain better therapeutic effect and excessive acupuncture stimulation may cause the body to develop a certain tolerance. However, the above results still need to be verified by more high-quality clinical studies. The protocol was registered on PROSPERO International Prospective Register of Systematic Reviews (CRD42022351428).

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Neuroprotective approaches to halt Parkinson's disease progression

Cited by 13 publications

References 287 publications

Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson’s disease model

Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson’s disease model

Acupuncture therapy for Parkinson’s disease: a case report demonstrating symptomatic improvement without medication

Qualitative and quantitative meta-analysis of acupuncture effects on the motor function of Parkinson's disease patients

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