Neuroprotective Compounds from Salix pseudo-lasiogyne Twigs and Their Anti-Amnesic Effects on Scopolamine-Induced Memory Deficit in Mice

Yang, Heejung; Lee, Sanghoon; Sung, Sang Hyun; Kim, Jinwoong; Kim, Young Choong

doi:10.1055/s-0032-1327949

Cited by 23 publications

(49 citation statements)

References 18 publications

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“…1C and D). Consistent with our results, it was recently reported that salicortin from Populus and Salix species significantly inhibited LPS-induced nitric oxide production in RAW264.7 cells and in BV2 microglial cells, although the molecular mechanisms of action has not yet been demonstrated (12,13). Besides the inhibitory effects on iNOS expression and NO production, salicortin also suppressed the expression of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in LPS-stimulated RAW 264.7 cells (Fig.…”

Section: Discussionsupporting

confidence: 93%

“…Recently, it was reported that salicortin significantly inhibited iNOS expression and NO production in LPS-stimulated macrophages and microglia (12, 13). Salicortin suppressed TNF-α-induced ICAM-1 expression in human endothelial cells (14).…”

Section: Introductionmentioning

confidence: 99%

“…Salicortin, a phenolic glycoside, is the dominant secondary metabolites in many plants, including Populus and Salix species, and exerts various biological effects, such as anti-amnesic and anti-adipogenic effects (11, 12). Recently, it was reported that salicortin significantly inhibited iNOS expression and NO production in LPS-stimulated macrophages and microglia (12, 13).…”

Section: Introductionmentioning

confidence: 99%

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Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages

Kwon¹,

Bae²,

Ju³

et al. 2014

BMB Reports

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We isolated the phenolic glucoside salicortin from a Populus euramericana bark extract, and examined its ability to suppress inflammatory responses as well as the molecular mechanisms underlying these abilities, using lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Salicortin inhibited iNOS expression and the subsequent production of NO in a dose-dependent manner in the LPS-stimulated RAW 264.7 cells. Salicortin significantly suppressed LPS-induced signal cascades of NF-κB activation, such as IKK activation, IκBα phosphorylation and p65 phosphorylation in RAW 264.7 cells. In addition, salicortin inhibited the LPS-induced activation of JNK, but not ERK or p38 MAPK. Furthermore, salicortin significantly inhibited production of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6 in the LPS-stimulated RAW 264.7 cells. These findings suggest that salicortin may show its anti-inflammatory activity by suppressing the LPS-induced expression of pro-inflammatory mediators through inhibition of NF-κB and JNK MAPK signaling cascades in macrophages. [BMB Reports 2014; 47(6): 318-323]

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages

Kwon¹,

Bae²,

Ju³

et al. 2014

BMB Reports

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“…and castoreum. Evidence suggests that it has antibacterial (Thomason et al, 2004), pain, headache (Wölfle et al, 2015), anti-inflammatory (Rudeekulthamrong and Kaulpiboon, 2016), analgesic, antipyretic (Pincock, 2005), thrombolytic (Jedinák et al, 2006), and neuro protective activity (Yang et al, 2013). It is structurally similar to aspirin and restricted to the patients having asthma, diabetes, gout, gastritis, hemophilia, stomach ulcers as well as children under 16, and pregnant and breastfeeding women.…”

Section: Introductionmentioning

confidence: 99%

Anticancer prospection of salicin, a historical origin of aspirin

Islam

Dantas²

2017

IJM

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Salicin (an alcoholic β-glucoside), the historical origin of aspirin. It is chemically related to aspirin and tastes bitter like quinine and evident for a number of important biological activities. The human bitter taste receptor TAS2R16 (hTAS2R16) responds to β-glucosides such as salicin. Thus, a modulator effect on this receptor may link to salicin-induced anticancer effect. Moreover, it may act by reducing oxidative stress and inflammatory reactions. Among a number of anticancer cellular and molecular mechanisms, salicin is evident to act through suppressing the angiogenic activity in cancer cells. Salicin may be one of the important anticancer drugs. However, the research on this willow plant derived compound is not sufficient, especially in the context of anticancer drug investigation.

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“…This antioxidative compound is able to reduce LPS-induced TNF-α expression in macrophages [8], LPSinduced NF-κB activation, NO, and TNF-α production in BV-2 microglia cells [9] and TNF-α-induced ICAM-1 expression in endothelial cells [5]. Yang et al demonstrated that among multiple isolated substances from Salix pseudo-lasiogyne, only those with a 1-hydroxy-6-oxo-2-cyclohexenecarboxylate moiety were able to decrease the LPS-induced NO production in BV-2 cells [10]. For antioxidants, an anti-inflammatory and cell protecting effect via the activation of the Nrf2-KEAP1 pathway has been described [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Catechol Conjugates Are In Vivo Metabolites of Salicis cortex

et al. 2013

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After oral administration of 100 mg/kg b. w. (235.8 µmol/kg) salicortin to Wistar rats, peak serum concentrations of 1.43 mg/L (13.0 µM) catechol were detected after 0.5 h in addition to salicylic acid by HPLC-DAD after serum processing with β-glucuronidase and sulphatase. Both metabolites could also be detected in the serum of healthy volunteers following oral administration of a willow bark extract (Salicis cortex, Salix spec., Salicaceae) corresponding to 240 mg of salicin after processing with both enzymes. In humans, the cmax (1.46 mg/L, 13.3 µM) of catechol was reached after 1.2 h. The predominant phase-II metabolite in humans and rats was catechol sulphate, determined by HPLC analysis of serum samples processed with only one kind of enzyme. Without serum processing with glucuronidase and sulphatase, no unconjugated catechol could be detected in human and animal serum samples. As catechol is described as an anti-inflammatory compound, these results may contribute to the elucidation of the mechanism of the action of willow bark extract.

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Neuroprotective Compounds from Salix pseudo-lasiogyne Twigs and Their Anti-Amnesic Effects on Scopolamine-Induced Memory Deficit in Mice

Cited by 23 publications

References 18 publications

Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages

Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages

Anticancer prospection of salicin, a historical origin of aspirin

Catechol Conjugates Are In Vivo Metabolites of Salicis cortex

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