Neuroprotective effect of asiatic acid against spinal cord injury in rats

Jiang, Wu; Li, Maoqiang; He, Fangping; Bian, Zhenyu; He, Qiwen; Wang, Xuepeng; Yao, Wangxiang; Zhu, Liangliang

doi:10.1016/j.lfs.2016.05.004

Cited by 56 publications

(45 citation statements)

References 49 publications

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“…These NRF2 targets, and others, are known to be induced by multiple compounds found in CA. Compounds such as the phenolic ferulic acid [89,90] and the triterpene asiatic acid [2,91], induce Nrf2 and its ARE-regulated targets, exhibiting a neuroprotective effect [92][93][94][95]. Caffeoylquinic acids found in CA [28,96,97], are also known to induce Nrf2 and Ho-1 signaling, and positively impact glutathione levels [98,99].…”

Section: Discussionmentioning

confidence: 99%

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

et al. 2019

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Centella asiatica (CA) herb is a traditional medicine, long reputed to provide cognitive benefits. We have reported that CA water extract (CAW) treatment improves cognitive function of aged Alzheimer’s disease (AD) model Tg2576 and wild-type (WT) mice, and induces an NRF2-regulated antioxidant response in aged WT mice. Here, CAW was administered to AD model 5XFAD female and male mice and WT littermates (age: 7.6 +/ − 0.6 months), and object recall and contextual fear memory were tested after three weeks treatment. CAW’s impact on amyloid-β plaque burden, and markers of neuronal oxidative stress and synaptic density, was assessed after five weeks treatment. CAW antioxidant activity was evaluated via nuclear transcription factor (erythroid-derived 2)-like 2 (NRF2) and NRF2-regulated antioxidant response element gene expression. Memory improvement in both genders and genotypes was associated with dose-dependent CAW treatment without affecting plaque burden, and marginally increased synaptic density markers in the hippocampus and prefrontal cortex. CAW treatment increased Nrf2 in hippocampus and other NRF2 targets (heme oxygenase-1, NAD(P)H quinone dehydrogenase 1, glutamate-cysteine ligase catalytic subunit). Reduced plaque-associated SOD1, an indicator of oxidative stress, was observed in the hippocampi and cortices of CAW-treated 5XFAD mice. We postulate that CAW treatment leads to reduced oxidative stress, contributing to improved neuronal health and cognition.

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Section: Discussionmentioning

confidence: 99%

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

et al. 2019

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“…AA inhibits neutrophil infiltration. MPO activity was assessed, as it is an oxidative enzyme in neutrophils and acts as a specific marker of neutrophil infiltration (16,17,21) (Fig. 2).…”

Section: Aa Reduces the Level Of Inflammatory Cytokines And Chemokinementioning

confidence: 99%

“…Asiatic acid (AA) is a natural triterpenoid extracted from Centella asiatica (16,17). It has many beneficial properties, including anti-inflammatory (16) and antioxidant (18) effects.…”

Section: Introductionmentioning

confidence: 99%

“…Asiatic acid (AA) is a natural triterpenoid extracted from Centella asiatica (16,17). It has many beneficial properties, including anti-inflammatory (16) and antioxidant (18) effects. Recently, AA has been demonstrated to control inflammation and exert protective effects via inhibiting NLRP3 inflammasome activation (16) and the NF-κB (19) pathway.…”

Section: Introductionmentioning

confidence: 99%

“…It has many beneficial properties, including anti-inflammatory (16) and antioxidant (18) effects. Recently, AA has been demonstrated to control inflammation and exert protective effects via inhibiting NLRP3 inflammasome activation (16) and the NF-κB (19) pathway. However, the effects of AA on PID remain unknown.…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of Asiatic acid against pelvic inflammatory disease in rats

Kong

Fu²,

Zhang³

et al. 2019

Exp Ther Med

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Asiatic acid (AA) is one of the major components of the Chinese herb Centella asiatica and exerts a variety of pharmacological activities. However, the pharmacological effects of AA on pelvic inflammatory disease (PID) remain unknown. The purpose of the present study was to investigate the therapeutic efficacy and potential mechanisms of AA on PID in rats. A total of 75 female Sprague Dawley rats were randomly divided into the following five groups: A control group; a PID group; a PID + AA 5 mg/kg group; a PID + AA 35 mg/kg group; and a PID + AA 75 mg/kg group. Changes in cytokine and chemokine levels, myeloperoxidase (MPO) activity, nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome and nuclear factor-κB (NF-κB) activation, oxidative stress and cleaved caspase-3 were measured. AA treatment significantly decreased the excessive production of cytokines and chemokines and suppressed MPO activity and the activation of NLRP3 inflammasome, NF-κB and caspase-3, as well as oxidative stress. These results suggest that AA exhibits potent anti-inflammatory and antioxidant effects in rats with pathogen-induced PID and that the mechanism of these anti-inflammatory effects may be associated with the suppression of NLRP3 inflammasome activation and the NF-κB pathway.

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The effect of the “segment” of spinal cord injury on the activity of the nucleotide‐binding domain‐like receptor protein 3 inflammasome and response to hormonal therapy

Majidpoor

Mortezaee

Khezri

et al. 2020

Cell Biochemistry & Function

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Spinal cord injury (SCI) is a common devastating condition that causes neuronal loss and dysfunction. Neuroinflammation takes cardinal roles in the pathogenesis of SCI, and nucleotide‐binding domain‐like receptor protein 3 (NLRP3) inflammasome is a mediator of inflammatory reactions occurring in SCI patients. The present study was designed to survey possible relation between thoracic segments whereby injury occurs with the activity of NLRP3 inflammasome complex, and to find the influence of hormonal therapy on the outcomes. Adult male Wistar rats underwent contusion SCI model at three different thoracic segments T1, T6 and T12, then receiving subcutaneous injection of either 10 mg/kg melatonin or 25 μg/kg 17‐β estradiol (E2) every 12 hours until 72 hours post‐SCI. Inflammasome activity was assessed before and at the end of hormonal therapy. SCI rats showed decreased locomotor activity and myelination, and increased activity of the NLRP3, apoptosis‐associated speck‐like protein (ASC) and caspase‐1 at gene and protein levels. Release of interleukins (ILs) 18 and 1β was also augmented after SCI (P < 0.0.5). Hormonal therapy was most effective for targeting mRNA activity at T6 segment. Treatment with either melatonin or E2 caused a decrease in the protein activity of NLRP3 inflammasome at all segments (P < 0.0.5), except for T6 that NLRP3 protein had no response to melatonin. IL‐1β showed decreased activity in response to hormonal therapy at all segments, whilst IL‐18 protein had no change at T1 segment. It is understood that although no alteration in the activity of NLRP3 was found for SCI at different segments, the response to hormonal therapy was influenced by segment. Significance of the study From our results, the NLRP3 inflammasome activity is not influenced by segment, but there are differences in the effect of hormonal therapy on inflammasome activity at different segments in response to melatonin or E2. These findings also provide the beneficial effects of melatonin or E2 on inflammation caused by spinal cord injury in different thoracic segments. Finally, these data can have therapeutic importance for hormone therapy of spinal cord injury.

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Neuroprotective effect of asiatic acid against spinal cord injury in rats

Cited by 56 publications

References 49 publications

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Protective effects of Asiatic acid against pelvic inflammatory disease in rats

The effect of the “segment” of spinal cord injury on the activity of the nucleotide‐binding domain‐like receptor protein 3 inflammasome and response to hormonal therapy

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