Neuroprotective effect of curcumin on spinal cord in rabbit model with ischemia/reperfusion

Liu, Zhiqiang; Shen, Xing; Zhang, Wei

doi:10.1179/2045772312y.0000000028

Cited by 18 publications

(6 citation statements)

References 27 publications

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“…Curcumin decreased oxidative stress by activating the Keap1/Nrf2/ARE signaling in diabetic rats [221]. Two other studies confirmed that curcumin decreased MDA levels and increased SOD and GPx levels after spinal cord ischemia-reperfusion injury [222,223]. Curcumin (300 mg/kg, i.p.)…”

Section: Caffeic Acid Phenethylmentioning

confidence: 90%

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Fakhri

Abbaszadeh

Moradi

et al. 2022

Oxidative Medicine and Cellular Longevity

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Despite the progression in targeting the complex pathophysiological mechanisms of neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective treatments. Moreover, conventional therapies suffer from associated side effects and low efficacy, raising the need for finding potential alternative therapies. In this regard, a comprehensive review was done regarding revealing the main neurological dysregulated pathways and providing alternative therapeutic agents following SCI. From the mechanistic point, oxidative stress and inflammatory pathways are major upstream orchestras of cross-linked dysregulated pathways (e.g., apoptosis, autophagy, and extrinsic mechanisms) following SCI. It urges the need for developing multitarget therapies against SCI complications. Polyphenols, as plant-derived secondary metabolites, have the potential of being introduced as alternative therapeutic agents to pave the way for treating SCI. Such secondary metabolites presented modulatory effects on neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in the onset and progression of SCI. In the present review, the potential role of phenolic compounds as critical phytochemicals has also been revealed in regulating upstream dysregulated oxidative stress/inflammatory signaling mediators and extrinsic mechanisms of axonal regeneration after SCI in preclinical and clinical studies. Additionally, the coadministration of polyphenols and stem cells has shown a promising strategy for improving post-SCI complications.

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Section: Caffeic Acid Phenethylmentioning

confidence: 90%

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Fakhri

Abbaszadeh

Moradi

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Another report examined antioxidant effects of curcumin specifically in the reperfusion phase of ischemic SCI [ 28 ]. Though ischemia is a relatively uncommon etiology of SCI, inflammation-induced neurological damage remains a central aspect of pathogenesis in both traumatic and nontraumatic SCI.…”

Section: Antioxidant Effectsmentioning

confidence: 99%

The Potential of Curcumin in Treatment of Spinal Cord Injury

Sanivarapu

Vallabhaneni

Verma

2016

Neurology Research International

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Current treatment for spinal cord injury (SCI) is supportive at best; despite great efforts, the lack of better treatment solutions looms large on neurological science and medicine. Curcumin, the active ingredient in turmeric, a spice known for its medicinal and anti-inflammatory properties, has been validated to harbor immense effects for a multitude of inflammatory-based diseases. However, to date there has not been a review on curcumin's effects on SCI. Herein, we systematically review all known data on this topic and juxtapose results of curcumin with standard therapies such as corticosteroids. Because all studies that compare the two show superior results for curcumin over corticosteroids, it could be true that curcumin better acts at the inflammatory source of SCI-mediated neurological injury, although this question remains unanswered in patients. Because curcumin has shown improvements from current standards of care in other diseases with few true treatment options (e.g., osteoarthritis), there is immense potential for this compound in treating SCI. We critically and systematically summarize available data, discuss clinical implications, and propose further testing of this well-tolerated compound in both the preclinical and the clinical realms. Analyzing preclinical data from a clinical perspective, we hope to create awareness of the incredible potential that curcumin shows for SCI in a patient population that direly needs improvements on current therapy.

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“…According to our results, the persistent exposure to O 3 could possibly require a dynamic adjustment of the initial dose of CUR and thus, improve the efficiency of the neuroprotective effect. The antiapoptotic mechanisms of CUR are the reduction of cytochrome C translocation, the decrease in Bax expression, the increase in Bcl-2 level, and the inhibition of caspases 3 and 9 activity [62,63,64,65]. In addition, the preventive approach presented a more pronounced antiapoptotic effect, possibly due to an anticipated increase in Bcl-2 levels and through the enhanced activity of major antioxidant enzymes like superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase through the activation of Nrf2 by CUR [66].…”

Section: Discussionmentioning

confidence: 99%

Dietary Curcumin Prevented Astrocytosis, Microgliosis, and Apoptosis Caused by Acute and Chronic Exposure to Ozone

et al. 2019

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Ozone is the most oxidant tropospheric pollutant gas, causing damage through the formation of reactive oxygen and nitrogen species. Reactive species induce the nuclear factor-kappa B (NF-κB) activation leading to neuroinflammation characterized by astrocytosis, microgliosis, and apoptotic cell death. There is interest in evaluating the pharmacological activity of natural antioxidants to confer neuroprotection against the damage caused by ozone in highly polluted cities. Curcumin has been proven to exert a protective action in the central nervous system (CNS) of diverse experimental models, with no side effects. The aim of this work is to evaluate the effect of curcumin in a preventive and therapeutic manner against the astrocytosis, microgliosis, and apoptosis induced by ozone in rat hippocampus. Fifty Wistar rats were distributed into five experimental groups: The intact control, curcumin fed control, ozone-exposed group, and the preventive and therapeutic groups receiving the curcumin supplementation while exposed to ozone. Ozone caused astrocytosis and microgliosis, as well as apoptosis in the hippocampus. Meanwhile, curcumin was able to decrease the activation of microglia and astrocytes, and apoptotic cell death in both periods of exposure. Therefore, we propose that curcumin could be used as a molecule capable of counteracting the damage caused by ozone in the CNS.

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Neuroprotective effect of curcumin on spinal cord in rabbit model with ischemia/reperfusion

Cited by 18 publications

References 27 publications

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

The Potential of Curcumin in Treatment of Spinal Cord Injury

Dietary Curcumin Prevented Astrocytosis, Microgliosis, and Apoptosis Caused by Acute and Chronic Exposure to Ozone

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