Neuroprotective effect of magnesium supplementation on cerebral ischemic diseases

Xu, Runnan; Wang, Liping; Sun, Liyuan; Dong, Jianghui

doi:10.1016/j.lfs.2021.119257

Cited by 23 publications

(15 citation statements)

References 180 publications

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“…IS is characterized by poor prognosis and easy coexistence with other chronic diseases, bringing severe psychological and economic burden to patients around the world [ 1 ]. The core treatment of IS is to unclog blocked blood vessels, but even after the unclog is completed, there are still risks like cerebral ischemic-reperfusion (CIR) injury [ 2 ]. The brain pathological mechanism of the CIR injury process is complex, usually involving energy metabolism disorder, inflammatory response, oxidative stress injury, cell necrosis and apoptosis, excitatory toxicity, and other processes [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Differences of Metabolites in Different Parts of the Brain Induced by Shuxuetong Injection against Cerebral Ischemia-Reperfusion and Its Corresponding Mechanism

Jiang

Jiao

Shang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Ischemic stroke is often associated with a large disease burden. The existence of ischemia-reperfusion injury brings great challenges to the treatment of ischemic stroke. The purpose of this study was to explore the differences of metabolites in different parts of the brain induced by Shuxuetong injection against cerebral ischemia-reperfusion and to extend the corresponding mechanism. The rats were modeled by transient middle cerebral artery occlusion (t-MCAO) operation, and the success of modeling was determined by neurological function score and TTC staining. UPLC-Q/TOF-MS metabolomics technique and multivariate statistical analysis were used to analyze the changes and differences of metabolites in the cortex and hippocampus of cerebral ischemia-reperfusion rats. Compared with the model group, the neurological function score and cerebral infarction volume of the Shuxuetong treatment group were significantly different. There were differences and changes in the metabolic distribution of the cortex and hippocampus in each group, the distribution within the group was relatively concentrated. The separation trend between the groups was obvious, and the distribution of the Shuxuetong treatment group was similar to that of the sham operation group. We identified 13 metabolites that were differentially expressed in the cortex, including glutamine, dihydroorotic acid, and glyceric acid. We also found five differentially expressed metabolites in the hippocampus, including glutamic acid and fumaric acid. The common metabolic pathways of Shuxuetong on the cortex and hippocampus were D-glutamine and D-glutamate metabolism and nitrogen metabolism, which showed inhibition of cortical glutamine and promotion of hippocampal glutamic acid. Specific pathways of Shuxuetong enriched in the cortex included glyoxylate and dicarboxylate metabolism and pyrimidine metabolism, which showed inhibition of glyceric acid and dihydroorotic acid. Specific pathways of Shuxuetong enriched in the hippocampus include arginine biosynthesis and citrate cycle (TCA cycle), which promotes fumaric acid. Shuxuetong injection can restore and adjust the metabolic disorder of the cortex and hippocampus in cerebral ischemia-reperfusion rats. The expression of Shuxuetong in different parts of the brain is different and correlated.

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Section: Introductionmentioning

confidence: 99%

The Differences of Metabolites in Different Parts of the Brain Induced by Shuxuetong Injection against Cerebral Ischemia-Reperfusion and Its Corresponding Mechanism

Jiang

Jiao

Shang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…An investigation reported that Mg supplementation by its role in brain revascularization can improve outcomes related to cerebral ischemia. The possible involving mechanisms may be associated with calcium antagonist and neuroprotective effects of Mg [43]. Another study demonstrated poor outcomes in traumatic brain injury patients with low serum and high cerebrospinal fluid magnesium levels compared to patients with normal magnesium levels [44].It has been also shown that daily Mg intake for more than 8 weeks could improve depression status in depressed cases [42].…”

Section: Mg/mg Deficiency and Nervous Systemmentioning

confidence: 99%

The possible correlation between magnesium deficiency and SARS-CoV-2 infection

Nazemi¹,

Shariat²,

Dallal³

et al. 2021

World J. Adv. Res. Rev.

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Magnesium (Mg) is an essential electrolyte for living organisms. It is the fourth most abundant mineral in the body. Although Mg is usually found in hard water and high-fiber diets, wide use of soft water and refined flour impose people at risk of Mg deficiency. Imbalances in Mg status and Mg deficiency may result in a variety of complications associated with the immune, cardiovascular, urinary, nervous, and respiratory systems. Because of the important roles of magnesium in the prevention and treatment of many diseases, several studies are focusing on the correlation between Mg status and Coronavirus disease 2019 (COVID-19). The present study reviewed several types of research to indicate the importance of monitoring of Mg status as well as the possible role of Mg supplementation for supportive treatment in COVID-19 patients. The results indicated that Mg deficiency could be a risk factor for multi-organ dysfunction in COVID-19 infection. Mg supplementation improves functions of the immune, cardiovascular, nervous, urinary, and respiratory systems through different mechanisms. Suppression of cytokine storm, bronchodilation, antithrombotic function, a decrease of arterial blood pressure, preventing electrolyte imbalance, increase stress resistance are some of the related mechanisms. These findings may provide a reference regarding the possible beneficial effects of the Mg supplement as an inexpensive, safe, and easily available drug for supportive treatment in COVID-19 patients.

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“…The observational nature of the studies and lack of RCTs is a limiting factor. Intravenous (iv) Mg supplementation (MgSO 4 ) versus placebo has been studied in large clinical trials [104], like a large multicenter trial in 2589 patients that failed to demonstrate a real benefit [105], or a randomized phase three trial with prehospital initiation of Mg in 857 patients that did not improve disability outcomes at 90 days [106]. Mg supplementation for cerebral ischemia has been administered with more invasive techniques (in the lateral ventricle, combined with hypothermia therapy, or with intracarotid Mg supplementation and selective hypothermia).…”

Section: Magnesium and Cardiovascular Functionmentioning

confidence: 99%

Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans

Pickering¹

2021

IJMS

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Magnesium (Mg) is a pivotal and very complex component of healthy aging in the cardiovascular-muscle-bone triad. Low Mg levels and low Mg intake are common in the general aging population and are associated with poorer outcomes than higher levels, including vascular calcification, endothelial dysfunction, osteoporosis, or muscle dysfunction/sarcopenia. While Mg supplementation appears to reverse these processes and benefit the triad, more randomized clinical trials are needed. These will allow improvement of preventive and curative strategies and propose guidelines regarding the pharmaceutical forms and the dosages and durations of treatment in order to optimize and adapt Mg prescription for healthy aging and for older vulnerable persons with comorbidities.

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Neuroprotective effect of magnesium supplementation on cerebral ischemic diseases

Cited by 23 publications

References 180 publications

The Differences of Metabolites in Different Parts of the Brain Induced by Shuxuetong Injection against Cerebral Ischemia-Reperfusion and Its Corresponding Mechanism

The Differences of Metabolites in Different Parts of the Brain Induced by Shuxuetong Injection against Cerebral Ischemia-Reperfusion and Its Corresponding Mechanism

The possible correlation between magnesium deficiency and SARS-CoV-2 infection

Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans

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