Neuroprotective Effect of Paeonol in the Rat Model of Traumatic Brain Injury

Arık, Emine; Dolgun, Habibullah; Bektaşoğlu, Pınar Kuru; Ergil, Jülide; Yılmaz, Banu Coşkun; Tönge, Çağhan; Öztürk, Özden Çağlar; Gürses, Levent; Gürer, Bora

doi:10.4274/atfm.galenos.2020.35229

Cited by 2 publications

(1 citation statement)

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“…Traumatic brain injury will result in disability or even death due to direct mechanical damage to neurons and cerebral vessels. After pretreatment with 50 mg/kg Pae, the degree of edema of damaged cells will be significantly reduced (Arık et al, 2020). In addition, it inhibits pyroptosis and downregulates levels of inflammatory cytokines IL‐1β, IL‐18, and TNF‐α in neurons with traumatic spinal cord injury, which are associated with TLR4/MyD88/NF‐κB‐mediated M1 depolarization in BV‐2 cells (Zhao et al, 2022).…”

Section: Protective Effect Of Pae On Cnsmentioning

confidence: 99%

Protective mechanism of Paeonol on central nervous system

Wu,

Liu,

Zhang

et al. 2023

Phytotherapy Research

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Cerebrovascular diseases involve neuronal damage, resulting in degenerative neuropathy and posing a serious threat to human health. The discovery of effective drug components from natural plants and the study of their mechanism are a research idea different from chemical synthetic medicines. Paeonol is the main active component of traditional Chinese medicine Paeonia lactiflora Pall. It widely exists in many medicinal plants and has pharmacological effects such as anti‐atherosclerosis, antiplatelet aggregation, anti‐oxidation, and anti‐inflammatory, which keeps generally used in the treatment of cardiovascular and cerebrovascular diseases. Based on the therapeutic effects of Paeonol for cardiovascular and cerebrovascular diseases, this article reviewed the pharmacological effects of Paeonol in Alzheimer's disease, Parkinson's disease, stroke, epilepsy, diabetes encephalopathy, and other neurological diseases, providing a reference for the research of the mechanism of Paeonol in central nervous system diseases.

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Section: Protective Effect Of Pae On Cnsmentioning

confidence: 99%