Neuroprotective effect of petroleum ether, methanolic and aqueous extracts of flower heads of Sphaeranthus indicus on lipofuscinogenesis and fluorescence product in brain of D-galactose induced aging accelerated mice

Ambikar, Digambar; Mohanta, Guru Prasad

doi:10.1007/s13596-013-0110-x

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…Saiyed et al (2015) tested (Garrido et al, 2009), the present findings on LI12542F6 showed no lethality in oral and dermal LD 50 limit tests in mice and rats (at 2,000 mg/kg body weight), with no adverse effects. Similarly, Nahata and Dixit (Nahata & Dixit, 2011) and Ambikar and Mohanta (Ambikar & Mohanta, 2013) found that extracts of S. indicus showed LD 50 values greater than 2,000 mg/kg body weight with no observed adverse effects. Meratrim ® was found to have an oral LD 50 in rats in excess of 5,000 mg/kg body weight, with a few minor effects in different animals, a dermal LD 50 greater than 2,000 mg/kg with no adverse effects seen, no dermal irritation and slight eye irritation (Saiyed et al, 2015).…”

Section: Discussionmentioning

confidence: 88%

“…Meratrim ® , a 3:1 mixture of S. indicus paste and Garcinia mangostana powder (with 55% excipients), in a battery of genotoxicity tests and rodent toxicity studies. Similarly, Nahata and Dixit(Nahata & Dixit, 2011) and Ambikar and Mohanta(Ambikar & Mohanta, 2013) found that extracts of S. indicus showed LD 50 values greater than 2,000 mg/kg body weight with no observed adverse effects. Furthermore, Meratrim ® did not induce chromosome aberrations in cultured lymphocytes.…”

mentioning

confidence: 88%

“…There are a number of toxicological studies on extracts and preparations of M. indica, including the active ingredient mangiferin (Garrido, Rodeiro, & Hernández, 2009;Prado et al, 2015;Rodeiro, Cancino, & González, 2006;Rodeiro, Hernandez, & Morffi, 2012), and of S. indicus (Ambikar & Mohanta, 2013;Nahata & Dixit, 2011;Saiyed, Sengupta, & Krishnaraju, 2015). It is important also to understand, using experimental toxicology studies, whether there are toxicological concerns related to the combination.…”

Section: Introductionmentioning

confidence: 99%

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Toxicological studies on the botanical supplement LI12542F6 containing extracts ofSphaeranthus indicusflower heads andMangifera indica(mango tree) bark

Nestmann¹,

Alluri

Dodda

et al. 2019

Food Science & Nutrition

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LI12542F6, a botanical extract composed of Sphaeranthus indicus and Mangifera indica, was evaluated for mutagenicity in bacteria, clastogenicity in mouse bone marrow, acute oral and dermal toxicity in the rat, irritation (dermal, eye) in rabbit, and subacute and subchronic toxicity (28 and 90 days) in the rat. All studies followed standard OECD test protocols, in accordance with the principles of Good Laboratory Practice (GLP). LI12542F6 did not induce mutations in the bacterial assay using Salmonella and Escherichia coli strains, nor did it induce genotoxic effects in erythrocytes from mouse bone marrow. LI12542F6 was found to have oral and dermal LD50 values greater than the limit dose of 2,000 mg/kg body weight in the rat. In an eye irritation/corrosion test, LI12542F6 caused conjunctival redness, corneal opacity, and chemosis and is classified as Category 2A (“irritating to eyes – reversible eye effect”). Doses in the 28‐day and 90‐day rat oral toxicity studies were 0, 500, 1,000, and 1,500 and 0, 1,000, 1,500, and 2,000 mg/kg body weight/day, respectively, administered by gavage. Both studies featured a recovery period. Minor effects were random and not treatment related except for local irritation of the forestomach in the 28‐day study, evidenced by histopathologic examination, in mid‐ and high‐dose animals. The frequency and severity of these effects were reduced in the recovery group; irritation was not found in the forestomach of rats in the 90‐day study. The no observed adverse effect level (NOAEL) was greater than the highest dose tested, that is, >2,000 mg/kg in the 90‐day study. This botanical composition will be marketed commercially for muscle health as Myotor™.

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Section: Discussionmentioning

confidence: 88%

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confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Toxicological studies on the botanical supplement LI12542F6 containing extracts ofSphaeranthus indicusflower heads andMangifera indica(mango tree) bark

Nestmann¹,

Alluri

Dodda

et al. 2019

Food Science & Nutrition

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“…After cotreatment with hydroalcoholic extract of Trapa bispinosa (500 mg/kg, p.o) there was decrease in fluorescence product in cerebral cortex. Moreover, T. bispinosa inhibited increased lipid peroxidation and restored glutathione peroxidase and catalase activity in cerebral cortex as compared to ageing accelerated control group [ 15 ].…”

Section: Pharmacology ( Table 4 )mentioning

confidence: 99%

Trapa bispinosaRoxb.: A Review on Nutritional and Pharmacological Aspects

Adkar

Dongare

Ambavade

et al. 2014

Advances in Pharmacological Sciences

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Trapa bispinosa Roxb. which belongs to the family Trapaceae is a small herb well known for its medicinal properties and is widely used worldwide. Trapa bispinosa or Trapa natans is an important plant of Indian Ayurvedic system of medicine which is used in the problems of stomach, genitourinary system, liver, kidney, and spleen. It is bitter, astringent, stomachic, diuretic, febrifuge, and antiseptic. The whole plant is used in gonorrhea, menorrhagia, and other genital affections. It is useful in diarrhea, dysentery, ophthalmopathy, ulcers, and wounds. These are used in the validated conditions in pitta, burning sensation, dipsia, dyspepsia, hemorrhage, hemoptysis, diarrhea, dysentery, strangely, intermittent fever, leprosy, fatigue, inflammation, urethrorrhea, fractures, erysipelas, lumbago, pharyngitis, bronchitis and general debility, and suppressing stomach and heart burning. Maybe it is due to photochemical content of Trapa bispinosa having high quantity of minerals, ions, namely, Ca, K, Na, Zn, and vitamins; saponins, phenols, alkaloids, H-donation, flavonoids are reported in the plants. Nutritional and biochemical analyses of fruits of Trapa bispinosa in 100 g showed 22.30 and 71.55% carbohydrate, protein contents were 4.40% and 10.80%, a percentage of moisture, fiber, ash, and fat contents were 70.35 and 7.30, 2.05 and 6.35, 2.30 and 8.50, and 0.65 and 1.85, mineral contents of the seeds were 32 mg and 102.85 mg calcium, 1.4 and 3.8 mg Iron, and 121 and 325 mg phosphorus in 100 g, and seeds of Trapa bispinosa produced 115.52 and 354.85 Kcal of energy, in fresh and dry fruits, respectively. Chemical analysis of the fruit and fresh nuts having considerable water content citric acid and fresh fruit which substantiates its importance as dietary food also reported low crude lipid, and major mineral present with confirming good amount of minerals as an iron and manganese potassium were contained in the fruit. Crude fiber, total protein content of the water chestnut kernel, Trapa bispinosa are reported. In this paper, the recent reports on nutritional, phytochemical, and pharmacological aspects of Trapa bispinosa Roxb, as a medicinal and nutritional food, are reviewed.

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“…Some species of Trapa have been used for many purposes such as nerve tonic, aphrodisiac Vyawahare and Ambikar 2010), and for sore throat (Xiao et al 2009;Ambikar et al 2010;Vyawahare and Ambikar 2010) and sore mouth (Xiao et al 2009). There are reports that Trapa has anti-inflammatory effects (Xiao et al 2009;Ambikar et al 2010;Vyawahare and Ambikar 2010), hepatoprotective activity , antimicrobial activity (Rahman et al 2001;Ambikar et al 2010), antioxidant activity (Song et al 2007;Ambikar et al 2010), tonic effect (Yoshida et al 1989), analgesic activity , and immunomodulator effect (Patel et al 2010). There are reports that suggest that the extracts of Trapa facilitate learning and memory, without affecting the motor coordination Vyawahare and Ambikar 2010).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Phenolic Acids in Water Caltrop by HPLC-DAD

et al. 2012

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Trapa natans L., or the water caltrop, a native plant of Romania, has not been researched in our country until recently. It has, however, been used for the treatment of the several diseases since ancient times. The objective of this work is to validate the HPLC method to detect and quantify the phenolic acids from Trapa natans L. specie. The HPLC-DAD method was validated for the analysis of 3-O-methylgallic, chlorogenic, caffeic, and ferulic acids in water caltrop roots, leaves, pulp, and hulls. The analysis was conducted on a Zorbax XDB-C18 column with gradient elution of acetonitrile-orthophosphoric acid. The method was validated in terms of linearity, accuracy, precision, limit of detection, quantification, and recovery, and found to be satisfactory. We verified the performance parameters after experimental studies, and we established that the HPLC method can be applied for the determination of phenolic acids in plant materials.

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Neuroprotective effect of petroleum ether, methanolic and aqueous extracts of flower heads of Sphaeranthus indicus on lipofuscinogenesis and fluorescence product in brain of D-galactose induced aging accelerated mice

Cited by 11 publications

References 18 publications

Toxicological studies on the botanical supplement LI12542F6 containing extracts ofSphaeranthus indicusflower heads andMangifera indica(mango tree) bark

Toxicological studies on the botanical supplement LI12542F6 containing extracts ofSphaeranthus indicusflower heads andMangifera indica(mango tree) bark

Trapa bispinosaRoxb.: A Review on Nutritional and Pharmacological Aspects

Simultaneous Determination of Phenolic Acids in Water Caltrop by HPLC-DAD

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