2019
DOI: 10.5530/pj.2019.11.243
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Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy

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Cited by 4 publications
(2 citation statements)
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References 18 publications
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“…A protective effect against the seizure, which was very similar to diazepam, was demonstrated using SIO administered at 1000mg/kgBW. The researchers inferred that the mechanism of SIO against PTZ-induced seizures involves the protection pathway via the generation of the neurotransmitter GABA and its cumulative antioxidant effects ( Herrera-Calderon et al., 2019 ). The core explanation involves the mechanism by which omega-3 PUFAs extending the refractory period in neurons, thus protect against the seizure episodes.…”
Section: Pharmacological Activitiesmentioning
confidence: 99%
“…A protective effect against the seizure, which was very similar to diazepam, was demonstrated using SIO administered at 1000mg/kgBW. The researchers inferred that the mechanism of SIO against PTZ-induced seizures involves the protection pathway via the generation of the neurotransmitter GABA and its cumulative antioxidant effects ( Herrera-Calderon et al., 2019 ). The core explanation involves the mechanism by which omega-3 PUFAs extending the refractory period in neurons, thus protect against the seizure episodes.…”
Section: Pharmacological Activitiesmentioning
confidence: 99%
“…En los seres humanos, el consumo de ácidos grasos omega-3 de cadena larga, que se encuentran en el pescado y otros productos alimenticios como el aceite de pescado, no solo contribuye al desarrollo del sistema nervioso central, sino que también puede reducir el riesgo de ciertas enfermedades del sistema nervioso o neurodegenerativas en adultos, incluida la artritis. Así, es necesario realizar más estudios en diferentes modelos experimentales para validar el uso de Sacha inchi como coadyuvante o protector en enfermedades inflamatorias (18) .…”
Section: Tratamientounclassified