Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons

Zeng, Xiang Jun; Yu, Shan Ping; Zhang, Like; Wei, Ling

doi:10.1016/j.yexcr.2010.02.005

Cited by 142 publications

(111 citation statements)

References 40 publications

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“…Studies on hippocampal cultures expressing APJ, and on mouse hearts, have also shown that apelin mediates the activation of ERK1/2 (O' Donnell et al 2007). However, apelin does not activate ERK1/2 in human osteoblasts and dose dependently decreases the phosphorylation of ERK1/2 in mouse cortical neurones, cells that endogenously express APJ (Xie et al 2006, Zeng et al 2010.…”

Section: Apj Signalling To Erk1/2mentioning

confidence: 92%

“…Apelin also activates Akt in HUVECs ) and in osteoblasts, where it has proliferative and anti-apoptotic effects (Xie et al 2006, 2007). Additionally, apelin activates Akt in rat hippocampal neuronal cultures, suggesting a neuroprotective role (O'Donnell et al 2007), while in mouse cortical neurones, the neuroprotective action of apelin is blocked by the PI3K inhibitor wortmannin, implicating the PI3K/Akt pathway in this process (Zeng et al 2010). APJ signalling via PI3K/Akt is also involved in proliferation and anti-apoptotic actions in rat and human VSMCs respectively (Cui et al 2010, Liu et al 2010.…”

Section: Apelin and The Pi3k/akt Pathwaymentioning

confidence: 99%

“…APJ signalling alters intracellular ROS, stimulating myocardial catalase generation and inhibiting hydrogen peroxide generation, to regulate cardiomyocyte hypertrophy (Foussal et al 2010), while long-term post-infarct treatment with (Pyr 1 )apelin-13 reduces ROS injury (Azizi et al 2013), thus exhibiting cardioprotective activity. Additionally, apelin prevents neuronal apoptosis in mouse cortical neurones by the reduction of ROS generation and activation of Akt (Zeng et al 2010), while the chronotropic effect of apelin-13 in the rostral ventrolateral medulla (RVLM) appears to be mediated by NAPDH oxidase-derived superoxide production (Yao et al 2011).…”

Section: Involvement Of Reactive Oxygen Species In Apj Signallingmentioning

confidence: 99%

“…Other possible roles for apelin and APJ in the rodent CNS include antinociception (Xu et al 2009, Lv et al 2012b, enhancement of depressive behaviour (Lv et al 2012a), and facilitation of passive avoidance learning (Telegdy et al 2013). Apelin may also have a role in neuroprotection, as apelin pre-treatment protects hippocampal neurones against N-methyl-Daspartate (NMDA) receptor-mediated excitotoxic injury (O'Donnell et al 2007), possibly via the phosphorylation of Akt and ERK1/2 (Zhou et al 2000, Cheng et al 2012, and prevents apoptosis in cultured mouse cortical neurones (Zeng et al 2010). Furthermore, apelin and APJ are expressed in osteoblasts where they may induce cell proliferation and promote survival (Xie et al 2006, 2007, Wattanachanya et al 2013; however, an increase in bone mass can be observed in apelin KO mice (Wattanachanya et al 2013).…”

Section: Other Functions Of the Apelinergic Systemmentioning

confidence: 99%

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The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

O’Carroll

Lolait

Harris

et al. 2013

Journal of Endocrinology

292

216

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The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled receptor gene family. Neural gene expression patterns of APJ, and its cognate ligand apelin, in the brain implicate the apelinergic system in the regulation of a number of physiological processes. APJ and apelin are highly expressed in the hypothalamo-neurohypophysial system, which regulates fluid homeostasis, in the hypothalamic-pituitary-adrenal axis, which controls the neuroendocrine response to stress, and in the forebrain and lower brainstem regions, which are involved in cardiovascular function. Recently, apelin, synthesised and secreted by adipocytes, has been described as a beneficial adipokine related to obesity, and there is growing awareness of a potential role for apelin and APJ in glucose and energy metabolism. In this review we provide a comprehensive overview of the structure, expression pattern and regulation of apelin and its receptor, as well as the main second messengers and signalling proteins activated by apelin. We also highlight the physiological and pathological roles that support this system as a novel therapeutic target for pharmacological intervention in treating conditions related to altered water balance, stress-induced disorders such as anxiety and depression, and cardiovascular and metabolic disorders.

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Section: Apj Signalling To Erk1/2mentioning

confidence: 92%

Section: Apelin and The Pi3k/akt Pathwaymentioning

confidence: 99%

Section: Involvement Of Reactive Oxygen Species In Apj Signallingmentioning

confidence: 99%

Section: Other Functions Of the Apelinergic Systemmentioning

confidence: 99%

See 2 more Smart Citations

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

O’Carroll

Lolait

Harris

et al. 2013

Journal of Endocrinology

292

216

View full text Add to dashboard Cite

show abstract

“…Apelin-13 can also protect against serum deprivationinduced apoptosis, as apelin-13 not only blocks typical apoptosis, but also exerts inhibitory effects on the NMDA-induced increase in intracellular Ca 2+ levels and excitotoxicity (51). The study of Khaksari et al (75) demonstrated that apelin-13 protects the brain against ischemia-reperfusion injury and cerebral edema.…”

Section: Apelin Protects the Central Nervous System By Stimulating Romentioning

confidence: 99%

Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)

Zhou

Cao

Chen

2016

International Journal of Molecular Medicine

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Abstract. Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, has been shown to be expressed in a variety of tissues in vivo and to exert significant biological effects. Studies have indicated that the apelin/APJ system is involved in the regulation of a variety of physiological functions and pathological processes, and that it is associated with cardiovascular diseases (such as atherosclerosis, hypertension, heart failure and myocardial injury), diabetes with microvascular complications, ischemia reperfusion injury, tumors, pre-eclampsia, as well as others. The occurrence of these diseases is closely related to endothelial dysfunction and the local inflammatory response; however, the occurrence of oxidative stress is related to vascular injury, due to the excessive generation of reactive oxygen species (ROS) and can lead to vascular damage and a series of inflammatory reactions. Therefore, this review summarizes the association between apelin/APJ, oxidative stress and inflammation-related diseases. In addition, drugs targeting the apelin/APJ system are recommended, thus providing a novel therapeutic strategy for oxidative stress-related inflammatory diseases.

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Serum apelin‐13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease

et al. 2021

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Alzheimer's disease (AD) is a progressive disorder that manifests itself with characteristic pathological changes in the brain, such as cognitive dysfunction, memory loss, senile plaques, and neurofibrillary tangles. 1 Although a clinical diagnosis of AD may be made after other causes of dementia have been excluded, a definite diagnosis may only be possible following postmortem evaluation of brain tissue for typical neuropathological findings. 2 With the aim of early initiation of treatment, the role of several biomarkers for the definite antemortem diagnosis of AD has been evaluated in recent years. The diagnostic criteria for AD were revised in 2007 and medial temporal lobe atrophy as a magnetic resonance imaging finding, as well as the novel cerebrospinal fluid (CSF) biomarkers, were considered supportive of diagnosis. 3 To date, three CSF biomarkers have been described; beta-amyloid 1-42 (Aβ 1-42), total tau (t-tau), and phospho-tau-181 (p-tau). However, obtaining a CSF sample may be challenging, which highlights the need for the determination of biomarkers from peripheral blood. 4 Apelin is a neuropeptide that was first segregated from bovine stomach tissue in 1998. It is an endogenous ligand for the APJ receptor. 5 The human preproapelin gene is located on chromosome Xq25-26.1. The apelin preproproteins consist of 77 amino acid residues that are cleaved into biologically active C-terminal fragments of various sizes. The apelin peptides, including 13 (65-77), 17 (61-77), and 36 (42-77) amino acids, are all capable of binding to APJ.

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Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons

Cited by 142 publications

References 40 publications

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)

Serum apelin‐13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease

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