Neuroprotective Effect of Xueshuantong for Injection (Lyophilized) in Transient and Permanent Rat Cerebral Ischemia Model

Wang, Xumei; Wang, Shaoxia; Guo, Hong; Dong, Zixing; Chai, Li‐Juan; Hu, Limin; Zhang, Yue; Wang, Hong; Chen, Lu

doi:10.1155/2015/134685

Cited by 23 publications

(13 citation statements)

References 38 publications

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“…Rhizome and root are both officially approved for the medicinal usage. However, there are still different applications of these two parts, for example, rhizome and main root are the raw materials of Chinese medicine Xuesaitong [31] and Xueshuantong [32] , respectively. Branch root and fibrous root are mainly used for producing health food and food supplement.…”

Section: Resultsmentioning

confidence: 99%

Investigating chemical features of Panax notoginseng based on integrating HPLC fingerprinting and determination of multiconstituents by single reference standard

Yang

Zhu

Zhang

et al. 2018

Journal of Ginseng Research

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BackgroundPanax notoginseng is a highly valued medicine and functional food, whose quality is considered to be influenced by the size, botanical parts, and growth environments.MethodsIn this study, a HPLC method integrating fingerprinting and determination of multiconstituents by single reference standard was established and adopted to investigate the chemical profiles and active constituent contents of 215 notoginseng samples with different sizes, from different botanical parts and geographical regions.ResultsChemical differences among main root, branch root, and rotten root were not distinct, while rhizome and fibrous root could be discriminated from other parts. The notoginseng samples from Wenshan Autonomous Prefecture and cities nearby were similar, whereas samples from cities far away were not. The contents of major active constituents in main root did not correlate with the market price.ConclusionThis study provided comprehensive chemical evidence for the rational usage of different parts, sizes, and growth regions of notoginseng in practice.

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Section: Resultsmentioning

confidence: 99%

Investigating chemical features of Panax notoginseng based on integrating HPLC fingerprinting and determination of multiconstituents by single reference standard

Yang

Zhu

Zhang

et al. 2018

Journal of Ginseng Research

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“…As previously described [17,28] , SLI and XST consist of many bioactive compounds, such as salvianolic acids (B, E), rosmarinic acid and lithospermic acid, and ginsenosides (Rg1, Rb1, R1, Re and Rd), some of which display neuroprotective effects after cerebral I/R injury. Salvianolic acid B exerts various pharmacological activities, such as anti-inflammation, antioxidation, promotion of cellular proliferation, anti-tumor and preservation of normal cell functions [49] .…”

Section: Discussionmentioning

confidence: 99%

“…Xueshuantong for injection (lyophilized) (XST) is a standardized product extracted from Sanqi. SLI is used extensively for the treatment of cardiovascular disease, cerebrovascular disease, and diabetes in China [17] .…”

Section: Introductionmentioning

confidence: 99%

Xueshuantong injection (lyophilized) combined with salvianolate lyophilized injection protects against focal cerebral ischemia/reperfusion injury in rats through attenuation of oxidative stress

Wang

Chai

et al. 2017

Acta Pharmacol Sin

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Salvianolate lyophilized injection (SLI) and Xueshuantong injection (lyophilized) (XST) are two herbal standardized preparations that have been widely used in China for the treatment of acute cerebral infarction. In this study, we investigated the neuroprotective effects of SLI combined with XST in a rat model of middle cerebral artery occlusion-reperfusion (MCAO/R). Wistar rats were subjected to 1.5 h of MCAO followed by reperfusion for 3 h, then were treated with SLI or XST alone, or with their combinations via tail vein injection daily for 3 d. Edaravone (EDI, 6 mg·kg·d) was used as a positive control drug, We showed that administration of a combination of 1X1S (XST 100 mg·kg·d plus SLI 21 mg·kg·d) more effectively protected the ischemic brains than SLI or XST used alone. Administration of 1X1S not only significantly decreased neurological deficit scores and infarct volumes and increased regional cerebral blood flow, but also inhibited the activation of both microglia and astrocytes in the hippocampus. Furthermore, administration of 1X1S significantly decreased the levels of MDA and ROS with concomitant increases in the levels of antioxidant activity (SOD, CAT and GSH) in the brain tissues as compared with SLI and XST used alone. Moreover, administration of 1X1S remarkably upregulated the expression of Nrf-2, HO-1 and NQO-1, and downregulated the expression of Keap1 and facilitated the nuclear translocation of Nrf-2 in the brain tissues as compared with XST used alone. Our study demonstrates that a combination of 1X1S effectively protects MCAO/R injury via suppressing oxidative stress and the Nrf-2/Keap1 pathway.

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“…Notoginseng total saponins, isolated from the root and rhizome of P. notoginseng , is the main component of XSTI. XSTI is generally used for treatment of cardiovascular and cerebrovascular disease [ 11 ]. Total revenue of XSTI in Chinese market in 2013 was over $700 million [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Post-marketing safety surveillance and re-evaluation of Xueshuantong injection

Li¹,

Xu²,

Zhou³

et al. 2018

BMC Complement Altern Med

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BackgroundTraditional Chinese medicine injections (TCMIs) have been widely used to treat severe and acute diseases due to their high bioavailability, accurate curative effect, and rapid effect. However, incidence rates of adverse drug reactions (ADRs) of TCMIs have also increased in recent years. Xueshuantong injection (XSTI) is a commonly-used TCMI comprised of Panax notoginseng total sapiens for the treatment of stroke hemiplegia, chest pain, and central retinal vein occlusion. Its safety remains uncelar. Therefore, post-marketing safety of XSTI was studied in this research.MethodsIn present study, post-marketing safety surveillance and re-evaluation of XSTI were reported. Thirty thousand eight hundred eighty-four patients in 33 hospitals from 7 provinces participated in this study. Incidence rate, most common clinical manifestations, types, severity, occurrence time, and disposal of ADRs were calculated.ResultsIncidence rate of ADR of XSTI was 4.14‰ and the most common clinical manifestations were skin and its appendages damage. Type A accounts for 95.49% of ADRs of XSTI and most of them (41.41%) were occurred within 24 h after receiving XSTI treatment. Severities of most ADRs of XSTI were moderate reactions (86.72%). Main disposition of ADRs of XSTI was drug withdrawal and symptomatic treatment (54.69%).ConclusionsOur data provide basis for improvement of instructions of XSTI and clinical safety of XSTI. Post-marketing surveillance of TCMIs in this study is a powerful tool to identify types and manifestations of ADRs to improve safety and effectiveness of drugs in clinical applications.Trial registrationThis protocol has international registration in China clinical trial registration center (ChiCTR~OPC~ 14,005,718) at December 22, 2014.

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Neuroprotective Effect of Xueshuantong for Injection (Lyophilized) in Transient and Permanent Rat Cerebral Ischemia Model

Cited by 23 publications

References 38 publications

Investigating chemical features of Panax notoginseng based on integrating HPLC fingerprinting and determination of multiconstituents by single reference standard

Investigating chemical features of Panax notoginseng based on integrating HPLC fingerprinting and determination of multiconstituents by single reference standard

Xueshuantong injection (lyophilized) combined with salvianolate lyophilized injection protects against focal cerebral ischemia/reperfusion injury in rats through attenuation of oxidative stress

Post-marketing safety surveillance and re-evaluation of Xueshuantong injection

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