2019
DOI: 10.3389/fphar.2019.00593
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Neuroprotective Effects and Hepatorenal Toxicity of Angong Niuhuang Wan Against Ischemia–Reperfusion Brain Injury in Rats

Abstract: Angong Niuhuang Wan (AGNHW) is a classic prescription in traditional Chinese medicine (TCM) used for stroke treatment, but its efficacies remain to be confirmed. With its arsenic- and mercury-containing materials, the application of AGNHW raises great safety concerns. Herein, we aim to explore the neuropharmacological effects against cerebral ischemia–reperfusion injury and evaluate the toxicological effects of AGNHW for better use. Male SD rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) … Show more

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Cited by 43 publications
(39 citation statements)
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“…Traditional Chinese medicines can therefore provide new approaches and solutions in the treatment of diseases such as cerebrovascular disease. In recent years, the clinical application of traditional Chinese medicines has increased significantly [39][40][41]. One aspect of the use of such medicines that requires close attention is how to achieve synergy and greater effects but at low doses.…”
Section: Discussionmentioning
confidence: 99%
“…Traditional Chinese medicines can therefore provide new approaches and solutions in the treatment of diseases such as cerebrovascular disease. In recent years, the clinical application of traditional Chinese medicines has increased significantly [39][40][41]. One aspect of the use of such medicines that requires close attention is how to achieve synergy and greater effects but at low doses.…”
Section: Discussionmentioning
confidence: 99%
“…The MCAO operation was established according to the previous protocol [ 23 ]. Briefly, rats were anaesthetized with 4% isoflurane (Abbott, IL, USA) and maintained at 2% isoflurane via inhalation.…”
Section: Methodsmentioning
confidence: 99%
“…Ischemia/reperfusion neuronal injury was induced in a middle cerebral artery (MCA) occlusion model, as reported previously [23]. The left external and common carotid arteries were exposed and ligated in anaesthetised animals.…”
Section: Methodsmentioning
confidence: 99%