Neuroprotective Effects of 7, 8-dihydroxyflavone on Midbrain Dopaminergic Neurons in MPP+-treated Monkeys

He, Jingjing; Xiang, Zhen; Zhu, Xiaoqing; Ai, Zongyong; Shen, Jingsong; Huang, Tianzhuang; Liu, Liegang; Ji, Weizhi; Li, Tianqing

doi:10.1038/srep34339

Cited by 36 publications

(25 citation statements)

References 26 publications

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“…These findings are in agreement with recent studies that have also identified flavone, catechin and ellagic acid as the major phenolic compounds in feijoa fruit [5,6,40]. It has been reported that 7,8-dihydroxyflavone exerts strong neuroprotective effects in monkeys [41], is effective in early brain trauma recovery in male rats [42], and has potential anticancer activity [40]. However, further studies on the potential health benefits of feijoa fruit in humans and the exact mode of action of its bioactive compounds are warranted.…”

Section: Resultssupporting

confidence: 92%

Nutritional Characteristics and Antimicrobial Activity of Australian Grown Feijoa (Acca sellowiana)

Phan

Chaliha

Sultanbawa

et al. 2019

Foods

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The present study determined the chemical composition, bioactive compounds and biological properties of Australian grown feijoa (Acca sellowiana), including whole fruit with peel, fruit peel and pulp, in order to assess the nutritional quality and antimicrobial activity of this emerging subtropical fruit. Polyphenolic compounds and vitamins were determined by UHPLC-PDA-MS/MS, showing that the feijoa fruit not only contains high amounts of antioxidant flavonoids, but is also a valuable source of vitamin C (63 mg/100 g FW (fresh weight)) and pantothenic acid (0.2 mg/100 g FW). Feijoa fruit is also a good source of dietary fibre (6.8 g/100 g FW) and potassium (255 mg/100 g FW). The edible fruit peel possesses significantly (p < 0.05) higher amounts of antioxidant flavonoids and vitamin C than the fruit pulp. This is most likely the reason for the observed strong antimicrobial activity of the peel-extracts against a wide-range of food-spoilage microorganism. The consumption of feijoa fruit can deliver a considerable amount of bioactive compounds such as vitamin C, flavonoids and fibre, and therefore, may contribute to a healthy diet. Furthermore, the potential use of feijoa-peel as a natural food perseverative needs to be investigated in follow-up studies.

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Section: Resultssupporting

confidence: 92%

Nutritional Characteristics and Antimicrobial Activity of Australian Grown Feijoa (Acca sellowiana)

Phan

Chaliha

Sultanbawa

et al. 2019

Foods

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“…Moreover, according to the results from in vivo pharmacokinetic studies in mice, DHF efficiently penetrates the brain after oral administration (50 mg/Kg), showing a brain to plasma concentration ratio of approximately 1:1 and an elimination half-life of about 2 hours 83 . However, an even longer half-life of 4–8 hours was measured in primate plasma after oral administration (30 mg/Kg) 150 . Although DHF has been shown to activate TrkB in the brain after acute administration 85 , 86 , we failed to detect any increase in TrkB phosphorylation in both WT and Ts65Dn mice after a single dose.…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Parrini

Ghezzi

Deidda

et al. 2017

Sci Rep

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Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabilities of the human syndrome. Aerobic exercise improved various neurophysiological dysfunctions in Ts65Dn mice, including hippocampal synaptic deficits, by promoting synaptogenesis and neurotransmission at glutamatergic terminals. Most importantly, the same intervention also prompted the recovery of hippocampal adult neurogenesis and synaptic plasticity and restored cognitive performance in trisomic mice. Additionally, the expression of brain-derived neurotrophic factor (BDNF) was markedly decreased in the hippocampus of patients with DS. Since the positive effect of exercise was paralleled by increased BDNF expression in trisomic mice, we investigated the effectiveness of a BDNF-mimetic treatment with 7,8-dihydroxyflavone at alleviating intellectual disabilities in the DS model. Pharmacological stimulation of BDNF signaling rescued synaptic plasticity and memory deficits in Ts65Dn mice. Based on our findings, Ts65Dn mice benefit from interventions aimed at promoting brain plasticity, and we provide evidence that BDNF signaling represents a potentially new pharmacological target for treatments aimed at rescuing cognitive disabilities in patients with DS.

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“…Although the action of TrkB receptor signalling is important for optimal neuronal function [20], the poor pharmacokinetic of BDNF [21] has limited the pharmacological implementation of BDNF to treat neurological disorders. The TrkB signalling cascade possesses the therapeutic potential to limit TBI pathology by critically linking energy metabolism and plasticity.…”

Section: Discussionmentioning

confidence: 99%

7,8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery

Krishna

Agrawal

Zhuang³

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Metabolic dysfunction accompanying traumatic brain injury (TBI) severely impairs the ability of injured neurons to comply with functional demands. This limits the success of rehabilitative strategies by compromising brain plasticity and function, and highlights the need for early interventions to promote energy homeostasis. We sought to examine whether the TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF) normalizes brain energy deficits and restablishes more normal patterns of functional connectivity, while enhancing the effects of exercise during post-TBI period. Moderate fluid percussion injury (FPI) was performed and 7,8-DHF (5 mg/kg, i.p.) was administered in animals subjected to FPI that either had access to voluntary wheel running for 7 days after injury or were sedentary. Compared to sham-injured controls, TBI resulted in reduced hippocampal activation of the BDNF receptor TrkB and associated CREB, reduced levels of plasticity markers GAP-43 and Syn I, as well as impaired memory as indicated by the Barnes maze task. While 7,8-DHF treatment and exercise individually mitigated TBI-induced effects, administration of 7,8-DHF concurrently with exercise facilitated memory performance and augmented levels of markers of cell energy metabolism viz., PGC-1α, COII and AMPK. In parallel to these findings, resting-state functional MRI (fMRI) acquired at 2 weeks after injury showed that 7,8-DHF with exercise enhanced hippocampal functional connectivity, and suggests 7,8-DHF and exercise to promote increases in functional connectivity. Together, these findings indicate that post-injury 7,8-DHF treatment promotes enhanced levels of cell metabolism, synaptic plasticity in combination with exercise increases in brain circuit function that facilitates greater physical rehabilitation after TBI.

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Neuroprotective Effects of 7, 8-dihydroxyflavone on Midbrain Dopaminergic Neurons in MPP+-treated Monkeys

Cited by 36 publications

References 26 publications

Nutritional Characteristics and Antimicrobial Activity of Australian Grown Feijoa (Acca sellowiana)

Nutritional Characteristics and Antimicrobial Activity of Australian Grown Feijoa (Acca sellowiana)

Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

7,8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery

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