Neuroprotective effects of a traditional herbal prescription on transient cerebral global ischemia in gerbils

Cai, Mudan; Shin, Bum Young; Kim, Dong Hyun; Kim, Jong Min; Park, Se Jin; Park, Chan Sung; Won, Do Hee; Hong, Nam Doo; Kang, Dong Hyo; Yamamoto, Yasutake; Ryu, Jong Hoon

doi:10.1016/j.jep.2011.10.016

Cited by 48 publications

(44 citation statements)

References 41 publications

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“…SQ12, 100 g) was obtained from Kwang Dong Pharmaceutical Company (Pyongtaek, Korea). The preparation was manufactured as previously described [20]. Briefly, juice from the root of Rehmannia glutinosa Liboschitz var.…”

Section: Methodsmentioning

confidence: 99%

“…Rats in the normal or KOK groups were administrated saline or KOK without DHEA injection. The dose of KOK was determined by a preliminary experiment for this study, by our previous report [20], by traditional prescription [13], and by well-known formula [23]. To evaluate the therapeutic effect of post-administration with KOK on PCOS, 15 days after the first DHEA injection the rats were randomly subdivided into the aforementioned six subgroups.…”

Section: Methodsmentioning

confidence: 99%

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Oriental Medicine Kyung-Ok-Ko Prevents and Alleviates Dehydroepiandrosterone-Induced Polycystic Ovarian Syndrome in Rats

Jang

Lee

et al. 2014

PLoS ONE

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Kyung-Ok-Ko (KOK), a traditional herbal prescription composed of Rehmannia glutinosa Liboschitz var. purpurae, Lycium chinense, Aquillaria agallocha, Poria cocos, Panax ginseng, and honey, has been widely used in traditional Oriental medicine as a vitalizing medicine or as the prescription for patients with age-associated disorders such as amnesia and stroke. However, the potential protective value of KOK for the treatment of polycystic ovarian syndrome (PCOS) is largely unknown. We investigated whether pre-administration (daily from 2 hours before PCOS induction) and post-administration (daily after induction of PCOS) of KOK (0.5, 1.0, and 2.0 g/kg/day, p.o.) could have a protective effect in a dehydroepiandrosterone (DHEA, s.c.)-induced PCOS rat model. Pre-administration of KOK significantly decreased the elevated body weight and ovary weight, elevated size and number of follicular cysts, elevated level of serum glucose, and estradiol after DHEA injection. KOK reduced the elevated percentage of CD8 (+) T lymphocytes in lymph nodes, the elevated mRNA expression of CD11b and CD3 in ovaries, and infiltration of macrophages in ovarian tissue with PCOS. KOK diminished the increased mRNA expression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), chemokines (IL-8, MCP-1), and iNOS in the ovaries, and increased the reduced mRNA expression of growth factors (EGF, TGF-β) by DHEA injection. Post-administration of KOK also improved the DHEA-induced PCOS-like symptoms, generally similar to those evident from pre-administration of KOK. KOK may effectively prevent and improve DHEA-induced PCOS via anti-inflammatory action, indicating its preventive and therapeutic potential for suppressing PCOS.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Oriental Medicine Kyung-Ok-Ko Prevents and Alleviates Dehydroepiandrosterone-Induced Polycystic Ovarian Syndrome in Rats

Jang

Lee

et al. 2014

PLoS ONE

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“…2 Similarly, in several other studies, both hydrogen peroxide-dependent and -independent antibacterial activity of honey was shown against various bacteria, including MRSA 100,103,106,245,267,268,276 ; the inhibition of bacterial growth depended on the type and concentration of honey, as well as on the test pathogen. Activity against Gram-positive and Gramnegative bacteria was shown to be due to antioxidant polyphenols (and other chemicals) in honey.…”

Section: Mechanism(s) Of Antibacterial Action Of Honey and Honey Compmentioning

confidence: 69%

Antimicrobial Properties of Honey

Israili¹

2014

American Journal of Therapeutics

184

144

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Honey has been widely accepted as food and medicine by all generations, traditions, and civilizations, both ancient and modern. For at least 2700 years, honey has been used by humans to treat a variety of ailments through topical application, but only recently have the antiseptic and antimicrobial properties of honey been discovered. Honey has been reported to be effective in a number of human pathologies. Clinical studies have demonstrated that application of honey to severely infected cutaneous wounds rapidly clears infection from the wound and improves tissue healing. A large number of in vitro and limited clinical studies have confirmed the broad-spectrum antimicrobial (antibacterial, antifungal, antiviral, and antimycobacterial) properties of honey, which may be attributed to the acidity (low pH), osmotic effect, high sugar concentration, presence of bacteriostatic and bactericidal factors (hydrogen peroxide, antioxidants, lysozyme, polyphenols, phenolic acids, flavonoids, methylglyoxal, and bee peptides), and increase in cytokine release, and to immune modulating and anti-inflammatory properties of honey; the antimicrobial action involves several mechanisms. Despite a large amount of data confirming the antimicrobial activity of honey, there are no studies that support the systemic use of honey as an antibacterial agent.

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“…Thus, honey consumption ameliorates the defense mechanism against oxidative stress and attenuated free radical-mediated molecular destruction [39]. Furthermore, honey decreased the number of degenerated neuronal cells in the hippocampal CA1 region, a region that is known to be highly susceptible to oxidative insult [42]. Theoretically, the cumulative macromolecular destruction by free radicals due to an imbalance between the prooxidant and antioxidant defense systems is implicated in aging [43].…”

Section: Effects Of Honey On Brain Structures and Functionsmentioning

confidence: 99%

Neurological Effects of Honey: Current and Future Prospects

Rahman

Gan

Khalil

2014

Evidence-Based Complementary and Alternative Medicine

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Honey is the only insect-derived natural product with therapeutic, traditional, spiritual, nutritional, cosmetic, and industrial value. In addition to having excellent nutritional value, honey is a good source of physiologically active natural compounds, such as polyphenols. Unfortunately, there are very few current research projects investigating the nootropic and neuropharmacological effects of honey, and these are still in their early stages. Raw honey possesses nootropic effects, such as memory-enhancing effects, as well as neuropharmacological activities, such as anxiolytic, antinociceptive, anticonvulsant, and antidepressant activities. Research suggests that the polyphenol constituents of honey can quench biological reactive oxygen species and counter oxidative stress while restoring the cellular antioxidant defense system. Honey polyphenols are also directly involved in apoptotic activities while attenuating microglia-induced neuroinflammation. Honey polyphenols are useful in improving memory deficits and can act at the molecular level. Therefore, the ultimate biochemical impact of honey on specific neurodegenerative diseases, apoptosis, necrosis, neuroinflammation, synaptic plasticity, and behavior-modulating neural circuitry should be evaluated with appropriate mechanistic approaches using biochemical and molecular tools.

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Neuroprotective effects of a traditional herbal prescription on transient cerebral global ischemia in gerbils

Cited by 48 publications

References 41 publications

Oriental Medicine Kyung-Ok-Ko Prevents and Alleviates Dehydroepiandrosterone-Induced Polycystic Ovarian Syndrome in Rats

Oriental Medicine Kyung-Ok-Ko Prevents and Alleviates Dehydroepiandrosterone-Induced Polycystic Ovarian Syndrome in Rats

Antimicrobial Properties of Honey

Neurological Effects of Honey: Current and Future Prospects

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