Neuroprotective effects of adipose-derived stem cells against ischemic neuronal damage in the rabbit spinal cord

Chung, Jin Young; Kim, Woosuk; Im, Wooseok; Yoo, Dae Young; Choi, Jung Hoon; Hwang, In Koo; Won, Moo‐Ho; Chang, In Bok; Cho, Byung Moon; Hwang, Ho Sik; Moon, Sung–Hoon

doi:10.1016/j.jns.2012.02.035

Cited by 39 publications

(31 citation statements)

References 52 publications

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“…Oh et al (42) used ADSCs to treat SCI and observed functional improvements. Similar results were demonstrated by Barriga et al (43), Ferrero-Gutierrez et al (44) and Chung et al (45). Therefore, this type of stem cell may be considered to be the most suitable for use as a seed cell for the treatment of SCI.…”

Section: Seed Cellsupporting

confidence: 89%

Tissue engineering is a promising method for the repair of spinal cord injuries (Review)

Zhou

et al. 2013

Experimental and Therapeutic Medicine

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Spinal cord injury (SCI) may lead to a devastating and permanent loss of neurological function, which may place a great economic burden on the family of the patient and society. Methods for reducing the death of neuronal cells, inhibiting immune and inflammatory reactions, and promoting the growth of axons in order to build up synapses with the target cells are the focus of current research. Target cells are located in the damaged spinal cord which create a connect with the scaffold. As tissue engineering technology is developed for use in a variety of different areas, particularly the biomedical field, a clear understanding of the mechanisms of tissue engineering is important. This review establishes how this technology may be used in basic experiments with regard to SCI and considers its potential future clinical use.

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Section: Seed Cellsupporting

confidence: 89%

Tissue engineering is a promising method for the repair of spinal cord injuries (Review)

Zhou

et al. 2013

Experimental and Therapeutic Medicine

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“…In support of this, rats implanted with ASC-derived SCs show not only significant locomotor function recovery compared with untreated ASCs but also a reduction in gliosis [261]. Reduced fibrosis and inflammation are also observed upon implantation of predifferentiated canine ASCs into spinal cord injuries [267] and upon intrathecal administration of ASCs into a model of ischemia/reperfusion neuronal damage in rabbits [268]. In addition to reducing gliosis, ASCderived SCs also appear to mediate the host's regenerative response through their ability to direct re-myelination.…”

Section: In Vivo Ectoderm Regeneration-nervousmentioning

confidence: 74%

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

2013

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In 2001, researchers at the University of California, Los Angeles, described the isolation of a new population of adult stem cells from liposuctioned adipose tissue. These stem cells, now known as adipose-derived stem cells or ADSCs, have gone on to become one of the most popular adult stem cells populations in the fields of stem cell research and regenerative medicine. As of today, thousands of research and clinical articles have been published using ASCs, describing their possible pluripotency in vitro, their uses in regenerative animal models, and their application to the clinic. This paper outlines the progress made in the ASC field since their initial description in 2001, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo, their use in mediating inflammation and vascularization during tissue regeneration, and their potential for reprogramming into induced pluripotent cells.

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“…Immunomodulatory effects of stem cells appear to reduce rejection of kidney transplants [16],[17], corneal allografts [18], and composite tissue hemi-facial allografts [19]. In the CNS, stem cells are reported to provide immunomodulatory and neuroprotective effects in models of diseases as disparate as retinopathy [20], neuronal ceroid lipofuscinosis [21], motor neuron disease [22],[23], Parkinson's disease [24], multiple sclerosis [25],[26], stroke [27]–[29], and spinal cord injury [30],[31].…”

Section: Introductionmentioning

confidence: 99%

Stem Cell Transplantation in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Animal Studies

et al. 2013

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Neuroprotective effects of adipose-derived stem cells against ischemic neuronal damage in the rabbit spinal cord

Cited by 39 publications

References 52 publications

Tissue engineering is a promising method for the repair of spinal cord injuries (Review)

Tissue engineering is a promising method for the repair of spinal cord injuries (Review)

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

Stem Cell Transplantation in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Animal Studies

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