Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta25–35-induced learning and memory impairments in mice

Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells

“…In a previous report, we demonstrated that EUE protects mice from Ab 25-35 -induced learning and memory impairments by inhibiting aceylcholinesterase (AChE) activity (Kwon et al, 2011). Although we reported that EUE had neuroprotective activity, we did not investigate the mechanism(s) of EUE action in our previous study.…”

Effect of Tong Luo Jiu Nao on Aβ-degrading enzymes in AD rat brains

“…Under anesthetization, peptides (10 g) or vehicle (saline) were respectively injected into the bilateral hippocampus CA1, with stereotaxic coordinates from the bregma being A −3.0 mm, L/R −2.0 mm, and V −3.0 mm. Peptides or vehicle were delivered gradually within a 10-min period followed by a rest period of 10 min (Maurice et al, 1996;Cheng et al, 2010;Kwon et al, 2011). The administration site was identified by injecting ink in preliminary experiments.…”

“…Long-term learning and memory were examined seven days after the bilateral hippocampus CA1 administration of A␤ peptides with the Y-maze using a passive avoidance test as previously described (Wolthuis, 1981;Maurice et al, 1997;Van der Borght et al, 2007;Kwon et al, 2011). Electric shocks were delivered to the grid floor with an isolated pulse stimulator.…”

Aroma of Eucommia leaf extract (ELE) causes reduced locomotor activity and increased NREM sleep, acting like the partially related factors of oral ELE's effects with locomotor-activity-dependent-increase in NREM- and REM-sleep

“…The bark of E. ulmoides (Cortex Eucommia) has been traditionally used as an herbal medicine with analeptic, analgesic, sedative, antihypertensive, and diuretic effects in Japan, China, and Korea. In vitro and in vivo studies indicated that the compounds and extracts from Eucommia ulmoides have various pharmacological effects in treating hypertension [10][11][12][13], hyperlipidemia [14,15], diabetes [16], obesity [14,[17][18][19][20], osteoporosis [21][22][23][24][25][26], and lupus-like syndrome [27], and promoting neuroprotection [28,29] and immunoregulation [30]. E. ulmoides leaves and barks have the same iridoid and lignin compound components; therefore, the leaves have been used similarly as the bark, as tonic and antihypertensive.…”