Neuroprotective effects of fermented soybean products (Cheonggukjang) manufactured by mixed culture of<i>Bacillus subtilis</i>MC31 and<i>Lactobacillus sakei</i>383 on trimethyltin-induced cognitive defects mice

Go, Jun; Kim, Ji Eun; Kwak, Moon Hwa; Koh, Eun Kyoung; Song, Sung Hwa; Sung, Ji Eun; Kim, Dong Sup; Hong, Jin Tae; Hwang, Dae Youn

doi:10.1179/1476830515y.0000000025

Cited by 28 publications

(24 citation statements)

References 60 publications

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“…Here, we sought to study the beneficial effects of melatonin on TMT‐induced neurotoxicity. Trimethyltin chloride induces seizure symptoms and the impairment of learning and memory according to the passive avoidance test, as previously reported . The results of our present study also demonstrated that TMT neurotoxicity is characterized by the deterioration of recognition memory, as shown by the NOR test in mice.…”

Section: Discussionsupporting

confidence: 92%

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Inhibition of SERPINA3N‐dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride–induced neurotoxicity

Liu

Hong

et al. 2019

Journal of Pineal Research

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Trimethyltin chloride (TMT) is a potent neurotoxin that causes neuroinflammation and neuronal cell death. Melatonin is a well‐known anti‐inflammatory agent with significant neuroprotective activity. Male C57BL/6J mice were intraperitoneally injected with a single dose of melatonin (10 mg/kg) before exposure to TMT (2.8 mg/kg, ip). Thereafter, the mice received melatonin (10 mg/kg, ip) once a day for another three consecutive days. Melatonin dramatically alleviated TMT‐induced neurotoxicity in mice by attenuating hippocampal neuron loss, inhibiting epilepsy‐like seizures, and ameliorating memory deficits. Moreover, melatonin markedly suppressed TMT‐induced neuroinflammatory responses and astrocyte activation, as shown by a decrease in inflammatory cytokine production as well as the downregulation of neurotoxic reactive astrocyte phenotype markers. Mechanistically, serine peptidase inhibitor clade A member 3N (SERPINA3N) was identified as playing a central role in the protective effects of melatonin based on quantitative proteome and bioinformatics analysis. Most importantly, melatonin significantly suppressed TMT‐induced SERPINA3N upregulation at both the mRNA and protein levels. The overexpression of Serpina3n in the mouse hippocampus abolished the protective effects of melatonin on TMT‐induced neuroinflammation and neurotoxicity. Melatonin protected cells against TMT‐induced neurotoxicity by inhibiting SERPINA3N‐mediated neuroinflammation. Melatonin may be a promising and practical agent for reducing TMT‐induced neurotoxicity in clinical practice.

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Section: Discussionsupporting

confidence: 92%

“…Mental confusion, memory defects, and seizures have been demonstrated to be typical clinical symptoms of acute exposure to TMT . Similarly, acute TMT toxicity induces seizures and deficiencies in learning and memory in rodent models . TMT selectively induces neuronal loss, particularly in the hippocampus .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of SERPINA3N‐dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride–induced neurotoxicity

Liu

Hong

et al. 2019

Journal of Pineal Research

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“…Expression of nerve growth factor (NGF) and activation of the NGF receptor signaling pathway were also upregulated in the cheonggukjang -treated group. Additionally, the level of SOD activity was enhanced, whereas malondialdehyde was lower in the cheonggukjang -treated group compared to the vehicle-treated group (29). In another study with AD and type 2 diabetes-induced rats, 8-week administration of cheonggukjang extract improved cognitive function and glucose regulation (30).…”

Section: The Effects Of Fermented Foods On Cognitive Functionmentioning

confidence: 97%

“…Cheonggukjang is one of the fermented soybean pastes used in Korean regional cuisine. In an animal study using cheonggukjang extract, a trimethyltin-treated group showed long- and short-term memory loss, whereas groups pretreated with cheonggukjang showed improved memory function in a dose-dependent manner (29). The number of cell death and AChE activity of the hippocampus were decreased in the cheonggukjang -treated group.…”

Section: The Effects Of Fermented Foods On Cognitive Functionmentioning

confidence: 99%

A Review of Fermented Foods with Beneficial Effects on Brain and Cognitive Function

Kim

Hong

Yang

et al. 2016

JFN

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Around the world, fermentation of foods has been adopted over many generations, primarily due to their commercial significance with enriched flavors and high-profile nutrients. The increasing application of fermented foods is further promoted by recent evidence on their health benefits, beyond the traditionally recognized effects on the digestive system. With recent advances in the understanding of gut-brain interactions, there have also been reports suggesting the fermented food’s efficacy, particularly for cognitive function improvements. These results are strengthened by the proposed biological effects of fermented foods, including neuroprotection against neurotoxicity and reactive oxygen species. This paper reviews the beneficial health effects of fermented foods with particular emphasis on cognitive enhancement and neuroprotective effects. With an extensive review of fermented foods and their potential cognitive benefits, this paper may promote commercially feasible applications of fermented foods as natural remedies to cognitive problems.

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“…Earlier reports (Ademiluyi et al., , ) that characterized the polyphenolic contents of both FLC and FSY via HPLC‐DAD reported the abundance of gallic acid, caffeic acid, quercetin, naringin, and kaempferol in both samples. Copious research findings have reported the bioactive properties of polyphenols and polyphenol‐rich plant extracts to include arginase (Girard‐Thernier et al., ; Oboh et al., ); PDE‐5 (Oboh, Ademiluyi, et al., ; Rahimi et al., ); AChE (Ademiluyi et al., ; Go et al., ; Mathew & Subramanian, ) and ecto‐5′nucleosidase (Akinyemi et al., ; Leal et al., ; Oboh, Adewuni, Ademosun, & Olasehinde, ) modulatory effects. Therefore, the observed enzyme modulatory effects of the condiments extract in this study could be associated with their abundance polyphenolic contents as previously reported.…”

Section: Discussionmentioning

confidence: 99%

Local condiments from fermented tropical legume seeds modulate activities of critical enzymes relevant to cardiovascular diseases and endothelial function

Ademiluyi

2018

Food Science & Nutrition

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Investigation into modulatory effects of local condiments produced from fermented legume (African locust bean and soybean) seeds on activities of enzymes relevant to endothelial function and cardiovascular disease (arginase, phosphodiesterase‐5, acetylcholinesterase, and, ecto 5′‐nucleotidase) in vitro was the focus of this study. The condiments were prepared according to traditional methods of fermentation. Thereafter, modulatory effects of aqueous extracts from the condiments on activities of the enzymes were subsequently carried out. Results showed the extracts significantly inhibited activities of arginase, phosphodiesterase‐5 and acetylcholinesterase, while the activity of ecto 5′‐nucleotidase was stimulated at sample concentrations tested. Thus, the observed enzyme modulatory properties exhibited by the condiments could be novel mechanisms to support their use as functional foods and nutraceuticals for the management of cardiovascular disease and associated endothelial dysfunction.

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Neuroprotective effects of fermented soybean products (Cheonggukjang) manufactured by mixed culture ofBacillus subtilisMC31 andLactobacillus sakei383 on trimethyltin-induced cognitive defects mice

Abstract: These results demonstrate that CGK fermented by mixed culture of B. subtilis and L. sakei could exert a wide range of beneficial activities for neurodegenerative diseases, including Alzheimer, Parkinson, and Huntington disease.

Cited by 28 publications

References 60 publications

Inhibition of SERPINA3N‐dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride–induced neurotoxicity

Inhibition of SERPINA3N‐dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride–induced neurotoxicity

A Review of Fermented Foods with Beneficial Effects on Brain and Cognitive Function

Local condiments from fermented tropical legume seeds modulate activities of critical enzymes relevant to cardiovascular diseases and endothelial function

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