Neuroprotective Effects of Flax Lignan Against <scp>NMDA</scp>‐Induced Neurotoxicity <i>In Vitr</i>o

Li, Xubo; Yang, Zhao-Xu; Yang, Le; Chen, Xiaoli; Zhang, Kun; Yang, Qi; Wu, Yumei; Liu, Shui-bing; Tao, Kaishan; Zhao, Ming

doi:10.1111/cns.12003

Cited by 18 publications

(11 citation statements)

References 34 publications

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Section: Usability Of Primary and Secondary Metabolitesmentioning

confidence: 99%

“…Phenolic stilbenes, flavonoids, and lignans are potential substances for biorefineries owing to their biological properties (Conde et al 2013;Li et al 2012). Flavonoids have biological, nutraceutical, and clinical effects (Maimoona et al 2011;Li et al 2012). Furthermore, lignans possess chemopreventive properties (Lampe Ríos and Recio 2005;Li et al 2012;Saxena 2015) that are used for health and welfare products.…”

Section: Usability Of Primary and Secondary Metabolitesmentioning

confidence: 99%

“…Flavonoids have biological, nutraceutical, and clinical effects (Maimoona et al 2011;Li et al 2012). Furthermore, lignans possess chemopreventive properties (Lampe Ríos and Recio 2005;Li et al 2012;Saxena 2015) that are used for health and welfare products. Lately, the interest in the phenolic compounds of these conifers has increased.…”

Section: Usability Of Primary and Secondary Metabolitesmentioning

confidence: 99%

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Bioactive phenolic compounds, metabolism and properties: a review on valuable chemical compounds in Scots pine and Norway spruce

2019

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Phenolics and extracted phenolic compounds of Scots pine (Pinus sylvestris) and Norway spruce (Picea abies) show antibacterial activity against several bacteria. The majority of phenolic compounds are stilbenes, flavonoids, proanthocyanidins, phenolic acids, and lignans that are biosynthesized in the wood through the phenylpropanoid pathway. In Scots pine (P. sylvestris), the most abundant phenolic and antibacterial compounds are pinosylvin-type stilbenes and flavonol-and dihydroflavonol-type flavonoids, such as kaempferol, quercetin, and taxifolin and their derivatives. In Norway spruce (P. abies) on the other hand, the main stilbene is resveratrol and the major flavonoids are quercetin and myricetin. In general, when the results from the literature regarding the activities of flavonoid glycosides and their aglycones against a total of twenty-one microorganisms are summarized, it was found that phenolic glycosides are less active than the corresponding aglycones, although a number of exceptions are also known. The aglycones in plants respond to various kinds of biotic stress. Synergistic effects between aglycones and their glycosides have been observed. Minimum inhibition concentrations of below 10 mg L-1 against bacteria have been reported for gallic acid, apigenin, and several methylated and acylated flavonols present in these industrially important trees. In general, the phenolic compounds are more active against Gram-positive bacteria, but apigenin is reported to exhibit strong activity against Gram-negative bacteria. The present review lists some of the biosynthesis pathways for the antibacterial phenolic metabolites found in Scots pine (P. sylvestris) and Norway spruce (P. abies). The antimicrobial activity of the compounds is collected and compared to gather information about the most effective secondary metabolites.

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Section: Usability Of Primary and Secondary Metabolitesmentioning

confidence: 99%

Section: Usability Of Primary and Secondary Metabolitesmentioning

confidence: 99%

Section: Usability Of Primary and Secondary Metabolitesmentioning

confidence: 99%

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Bioactive phenolic compounds, metabolism and properties: a review on valuable chemical compounds in Scots pine and Norway spruce

2019

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“…Lignans occurring in softwoods possess chemopreventive properties (Lampe 2003), present antioxidant and antitumor activities, cause neuroprotective effects (Li et al 2012), and can be employed cytotoxic antimicrobial agents . On the other hand, the associations between lignans and decreased risk of cardiovascular disease are promising, but they are not yet well established, perhaps due to low lignan intakes in habitual Western diets (Peterson et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Components of Pinus pinaster Wood

Conde¹,

Fang²,

Hemming³

et al. 2013

BioResources

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Aqueous fractionation of wood has been proposed as a suitable processing method for biorefineries. When treatments are performed under low severity conditions, water-soluble components (which could be detrimental in further processing stages) are removed, whereas polysaccharides, lignin, and other water-insoluble constituents remain in solid phase with little alteration. In order to explore the presence of added-value products in aqueous extracts from Pinus pinaster wood, different samples (heartwood and sapwood with and without knots) were extracted with water at 130 to 140 ºC, and the resulting solutions were assayed for yield and composition (by GC-FID, GC-MS, and HPLC). The major extract components, such as polysaccharide-derived products, simple phenolics, stilbenes, lignans, flavonoids, organic acids, jubaviones, steryl esters, and triglycerides, were identified and quantified. In order to assess a possible application of the extracts, their antioxidant activity was measured using the Trolox Equivalent Antioxidant Capacity assay.

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“…Consecutively Flax Lignans (FLL) has also been in the queue of holding neuroprotective potential which has been supported by few studies. FLL reduced intracellular Ca 2+ and balanced expression of Bcel-2 and Bax, further reduced the upregulation of GluN2B subunit containing NMDA receptor in NMDA exposed cells [126]. Since NMDA receptor plays a role in the mechanism of synaptic transmission, the FLL can improve the learning abilities and memory of AD patients.…”

Section: Lignans With Anti-ad Effectmentioning

confidence: 94%

A Mini Review on the Protective Effect of Lignans for the Treatment of Neurodegenerative Disorders

2019

NFLS

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Nature is a rich source of numerous bioactive compounds that are categorized as secondary metabolites. Lignans are group of such compounds, generally called phytoestrogens widely present in many plants and vegetables, grains, seeds, nuts and tea. They have been used as folk medicine for the treatment of several clinical conditions like asthma, cardiovascular diseases, arthrosclerosis, colitis and many more. Structurally, lignans are characterized by two phenylpropane groups attached by a carbon bond. They have been divided in to several types on the basis of structure of their carbon skeleton, the way of cyclization and oxygen incorporation in the skeleton. Lignans from numerous plant species such as Kadsura

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Neuroprotective Effects of Flax Lignan Against NMDA‐Induced Neurotoxicity In Vitro

Abstract: These findings suggest that FLL protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptor and regulating the Bcl-2 family.

Cited by 18 publications

References 34 publications

Bioactive phenolic compounds, metabolism and properties: a review on valuable chemical compounds in Scots pine and Norway spruce

Bioactive phenolic compounds, metabolism and properties: a review on valuable chemical compounds in Scots pine and Norway spruce

Water-Soluble Components of Pinus pinaster Wood

A Mini Review on the Protective Effect of Lignans for the Treatment of Neurodegenerative Disorders

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