Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson’s disease: motor and non‐motor outcomes

Bigham, Maryam; Mohammadipour, Abbas; Hosseini, Mahmoud; Malvandi, Amir Mohammad; Ebrahimzadeh‐Bideskan, Alireza

doi:10.1007/s11011-021-00705-8

Cited by 27 publications

(15 citation statements)

References 57 publications

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“…At the end of the lactation period, one male offspring from each dam was anesthetized and sacrificed by ketamine (75 mg/kg, i. p) and xylazine (10 mg/kg, i. p) (Bigham et al, 2021) on postnatal day 22 (PD22). Then, the right hippocampi were kept at À80°c to evaluate malondialdehyde (MDA), thiol, and superoxide dismutase (SOD).…”

Section: Estimation Of Oxidative and Antioxidative Parametersmentioning

confidence: 99%

“…The male offspring with 22 days of age were sacrificed after anesthetizing by ketamine (75 mg/kg, i. p) and xylazine (10 mg/kg, i. p) (Bigham et al, 2021) and perfused using 10% normalin solution. The brains were removed and further fixed for 1 week in 10% normalin.…”

Section: Histological Evaluationsmentioning

confidence: 99%

“…Immunohistochemistry was performed based on our laboratory routine protocol described previously (Bigham et al, 2021;Heidari et al, 2019;). Briefly, on the first day, after deparaffinization by xylene, the sections were placed in ethanol, distilled water, and PBS.…”

Section: Immunohistochemistry (Ihc)mentioning

confidence: 99%

“…"ΣQ" is the counted cells, "a/f" is the area associated with each frame of the grid, and "ΣP" represents the total number of grid frames (Bigham et al, 2021;Fani et al, 2018).…”

Section: Toluidine Blue Stainingmentioning

confidence: 99%

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Maternal exposure to silicon dioxide nanoparticles reduces hippocampal neurogenesis and synaptogenesis and induces neurodegeneration in rat offspring hippocampus

et al. 2022

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Silicon dioxide nanoparticles (SiO2-NPs) are among the most widely used nanoparticles because of their chemical-physical properties. Since most brain maturation occurs in the neonatal period in humans and many mammals, it is important to understand how NPs may affect this process. This study tested the hypothesis that SiO2-NPs from treated dams could affect the hippocampus of neonatal rats during lactation. Twenty-four pregnant rats, after delivery, were divided into three groups of control, SiO2-NPs (25 mg/kg) and SiO2-NPs (100 mg/kg). The rats were treated from 2nd to 21st days post-delivery by gavage and the effects of these NPs were evaluated in the offspring’s hippocampi to reveal the effects of maternal exposure to SiO2-NPs during lactation on the offspring’s hippocampi. The offspring in the SiO2-NPs groups had higher malondialdehyde concentration and lower antioxidant activity in the hippocampi than the non-treated control group. The mean number of doublecortin positive (DCX+) cells and synaptophysin expression in the hippocampi of the SiO2-NPs groups were significantly lower than the control group, whereas the mean number of dark neurons was significantly higher. Also, animals in the SiO2-NPs groups had a weak cognitive performance in adulthood. In conclusion, maternal exposure to SiO2-NPs via breastfeeding could affect offspring’s hippocampal neurogenesis and synaptogenesis, leading to impaired cognitive performance.

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Section: Estimation Of Oxidative and Antioxidative Parametersmentioning

confidence: 99%

Section: Histological Evaluationsmentioning

confidence: 99%

Section: Immunohistochemistry (Ihc)mentioning

confidence: 99%

“…"ΣQ" is the counted cells, "a/f" is the area associated with each frame of the grid, and "ΣP" represents the total number of grid frames (Bigham et al, 2021;Fani et al, 2018).…”

Section: Toluidine Blue Stainingmentioning

confidence: 99%

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Maternal exposure to silicon dioxide nanoparticles reduces hippocampal neurogenesis and synaptogenesis and induces neurodegeneration in rat offspring hippocampus

et al. 2022

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“…[ 72 ]. Garlic extract protected the dopaminergic neurons in 6-hydroxydopamine (6-OHDA) injected rats (which is used as a model for Parkinson’s disease) by improving 6-OHDA-induced motor dysfunctions and alleviating non-motor deficits, including memory impairment and anxiety in rats [ 73 ]. In rat brain synaptosomes, SAC, which is a compound in AGE, decreased lipid peroxidation and mitochondrial dysfunction induced by 3-nitropropionic acid, which produces oxidative and nitrosative stress and evokes an experimental model of Huntington’s disease.…”

Section: Effects Of Garlic On Neurodegenerative Diseasesmentioning

confidence: 99%

Antitumor Effects of Natural Compounds Derived from Allium sativum on Neuroblastoma: An Overview

et al. 2021

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Garlic (Allium sativum) has been used in alternative medicine to treat several diseases, such as cardiovascular and neurodegenerative diseases, cancer, and hepatic diseases. Several publications have highlighted other features of garlic, including its antibacterial, antioxidative, antihypertensive, and antithrombotic properties. The properties of garlic result from the combination of natural compounds that act synergistically and cause different effects. Some garlic-derived compounds have been studied for the treatment of several types of cancer; however, reports on the effects of garlic on neuroblastoma are scarce. Neuroblastoma is a prevalent childhood tumor for which the search for therapeutic alternatives to improve treatment without affecting the patients’ quality of life continues. Garlic-derived compounds hold potential for the treatment of this type of cancer. A review of articles published to date on some garlic compounds and their effect on neuroblastoma was undertaken to comprehend the possible therapeutic role of these compounds. This review aimed to analyze the impact of some garlic compounds on cells derived from neuroblastoma.

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The Role of Antioxidant on Health and Age-Related Diseases in Aging

Tan

Norhaizan

2021

The Role of Antioxidants in Longevity and Age-Related Diseases

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Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson’s disease: motor and non‐motor outcomes

Cited by 27 publications

References 57 publications

Maternal exposure to silicon dioxide nanoparticles reduces hippocampal neurogenesis and synaptogenesis and induces neurodegeneration in rat offspring hippocampus

Maternal exposure to silicon dioxide nanoparticles reduces hippocampal neurogenesis and synaptogenesis and induces neurodegeneration in rat offspring hippocampus

Antitumor Effects of Natural Compounds Derived from Allium sativum on Neuroblastoma: An Overview

The Role of Antioxidant on Health and Age-Related Diseases in Aging

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