Neuroprotective effects of NGF, BDNF, NT-3 and GDNF on axotomized extraocular motoneurons in neonatal rats

Morcuende, Sara; Muñoz, Rodrigo; Benítez‐Temiño, Beatriz; Pastor, Ángel M.; Cruz, Rosa R. de la

doi:10.1016/j.neuroscience.2013.06.050

Cited by 57 publications

(62 citation statements)

References 91 publications

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“…In agreement with our data in extraocular motoneurons [113], NT-3 applied to severed motoneurons in new born rats also exhibit some ability to rescue motoneurons from cell death, but less efficiently than BDNF, both in spinal [122] and facial [110] motoneurons. In the adult rat, the administration of NT-3 exerts no protective effect on cell death in hypoglossal motoneurons after nerve transection [91] or in corticospinal neurons after central lesion [123].…”

Section: Survival Of Extraocular Motoneurons After Postnatal Axotomy supporting

confidence: 92%

“…In neonatal rats, the effect of the administration of neurotrophins on extraocular motoneuron survival at a longer post-lesion time revealed that the prevention of motoneuronal death observed 10 days after axotomy was also present by 30 days post-lesion [113]. These results indicate that the enhanced survival induced by these neurotrophins was not transient, but rather extended throughout a long period.…”

Section: Long-lasting Effects Of Neurotrophic Factors In Extraocular mentioning

confidence: 78%

“…We demonstrated that extraocular muscles of neonatal rats express the neurotrophins NGF, BDNF and NT-3 [113], and also that motoneurons of the oculomotor system contain the TrkA, TrkB and TrkC receptors [49,84], indicating that neurotrophins delivered from the target likely play a relevant role in extraocular motoneurons. In order to uncover the degree of dependence of extraocular motoneurons on different neurotrophins in the period in which they are more vulnerable to the deprivation of neurotrophic supply, new born rats were monocularly enucleated as a procedure to axotomize extraocular motoneurons, and different neurotrophins were applied to the orbit immediately after lesion [113].…”

Section: Survival Of Extraocular Motoneurons After Postnatal Axotomy mentioning

confidence: 99%

“…Neonatal enucleation in P0 resulted in a massive death of approximately 65% of extraocular motoneurons by 10 days after lesion [113]. The exogenous administration of diverse neurotrophic factors at the moment of the axotomy was performed by the application of Gelfoam implants soaked in diverse neurotrophins (NGF, BDNF or NT-3) into the enucleated ocular orbit.…”

Section: Survival Of Extraocular Motoneurons After Postnatal Axotomy mentioning

confidence: 99%

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Complementariness and Functional Parcellation of Neurotrophin Actions on the Oculomotor System

Benítez‐Temiño¹,

Davis-López²,

Morcuende³

et al. 2016

Preprint

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Abstract:Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated that neurotrophins are key regulators of developing and adult neuronal properties, but with peculiarities depending on each neurotrophin. For instance, the administration of NGF, BDNF or NT-3 protects neonatal extraocular motoneurons from cell death after axotomy, but only NGF and BDNF prevent the downregulation in ChAT. In the adult, in vivo recordings of axotomized extraocular motoneurons have demonstrated that the delivery of NGF, BDNF or NT-3 recovers different components of the firing discharge activity of these cells, with some particularities in the case of NGF. All neurotrophins have also synaptotrophic activity, although to different degrees. Accordingly, neurotrophins can restore the axotomy-induced alterations acting selectively on different properties of the motoneuron. In this review we summarize these evidences and discuss them in the context of other motor systems.

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Section: Survival Of Extraocular Motoneurons After Postnatal Axotomy supporting

confidence: 92%

Section: Long-lasting Effects Of Neurotrophic Factors In Extraocular mentioning

confidence: 78%

Section: Survival Of Extraocular Motoneurons After Postnatal Axotomy mentioning

confidence: 99%

Section: Survival Of Extraocular Motoneurons After Postnatal Axotomy mentioning

confidence: 99%

See 2 more Smart Citations

Complementariness and Functional Parcellation of Neurotrophin Actions on the Oculomotor System

Benítez‐Temiño¹,

Davis-López²,

Morcuende³

et al. 2016

Preprint

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“…Schwann cells (SCs), forming the predominant component of glial cells in the peripheral nervous system, are known to express a number of receptors for ECM molecules and NTFs [41, 141]. It is proposed that NTFs exhibit their actions by binding to two receptor types, namely, the p75NTR receptor and the Trk class of receptors comprising TrkA (NGF), TrkB (BDNF), and TrkC (NT-3) located on SCs and neurons throughout the nervous system [33, 142, 143]. SCs have been reported to particularly express high levels of the p75NTR receptor which NTFs act on to modulate the migration, proliferation, and myelination capacities of SCs in peripheral nerves [144–146].…”

Section: Combined Delivery Of Neurotrophic Factors: Effects On Neumentioning

confidence: 99%

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury

Ramburrun

Kumar

Choonara

et al. 2014

BioMed Research International

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Peripheral nerve regeneration strategies employ the use of polymeric engineered nerve conduits encompassed with components of a delivery system. This allows for the controlled and sustained release of neurotrophic growth factors for the enhancement of the innate regenerative capacity of the injured nerves. This review article focuses on the delivery of neurotrophic factors (NTFs) and the importance of the parameters that control release kinetics in the delivery of optimal quantities of NTFs for improved therapeutic effect and prevention of dose dumping. Studies utilizing various controlled-release strategies, in attempt to obtain ideal release kinetics, have been reviewed in this paper. Release strategies discussed include affinity-based models, crosslinking techniques, and layer-by-layer technologies. Currently available synthetic hollow nerve conduits, an alternative to the nerve autografts, have proven to be successful in the bridging and regeneration of primarily the short transected nerve gaps in several patient cases. However, current research emphasizes on the development of more advanced nerve conduits able to simulate the effectiveness of the autograft which includes, in particular, the ability to deliver growth factors.

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The Amniote Oculomotor Complex

Company

Moreno-Bravo

Pérez-Balaguer

et al. 2018

The Anatomical Record

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The oculomotor (OM) complex is a combination of somatic and parasympatethic neurons. The correct development and wiring of this cranial pair is essential to perform basic functions: eyeball and eyelid movements, pupillary constriction, and lens accommodation. The improper formation or function of this nucleus leads pathologies such as strabismus. We describe the OM organization and function in different vertebrate brains, including chick, mouse, and human. The morphological localization is detailed, as well as the spatial relation with the trochlear nucleus in order to adjust some misleading anatomical topographic descriptions. We detailed the signaling processes needed for the specification of the OM neurons. The transcriptional programs driven the specification and differentiation of these neurons are partially determined. We summarized recent genetic studies that have led to the identification of guidance mechanisms involved in the migration, axon pathfinding, and targeting of the OM neurons. Finally, we overviewed the pathology associated to genetic malformations in the OM development and related clinical alterations. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc.

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Neuroprotective effects of NGF, BDNF, NT-3 and GDNF on axotomized extraocular motoneurons in neonatal rats

Cited by 57 publications

References 91 publications

Complementariness and Functional Parcellation of Neurotrophin Actions on the Oculomotor System

Complementariness and Functional Parcellation of Neurotrophin Actions on the Oculomotor System

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury

The Amniote Oculomotor Complex

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