Neuroprotective metabolites from the endophytic fungus Penicillium citrinum of the mangrove Bruguiera gymnorrhiza

Wu, Yanzhi; Qiao, Fang; Guo-li, XU; Zhao, Jie; Teng, Junfang; Li, Chun; Deng, Wenjing

doi:10.1016/j.phytol.2015.03.007

Cited by 37 publications

(20 citation statements)

References 17 publications

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“… 12 – 14 (Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside (DHAG), a compound isolated from the endophytic fungus Penicillium citrinum of Bruguiera gymnorrhiza ., was shown to have neuroprotective effects via inhibition of oxidative stress. 15 Furthermore, DHAG was also found to inhibit LTA-induced production of inflammatory factors in our preliminary study. In the present study, the protective effects of DHAG against LTA-induced inflammatory responses and oxidative stress in cardiomyoblasts were investigated.…”

Section: Introductionmentioning

confidence: 57%

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(Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside attenuates lipoteichoic acid-induced damage in rat cardiomyoblast cells

Song

Xie

et al. 2020

J Int Med Res

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Objective Excessive inflammatory responses in the endocardium are related to progression of infectious endocarditis. This study aimed to investigate whether (Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside (DHAG), a compound isolated from the endophytic fungus Penicillium citrinum of Bruguiera gymnorrhiza, could attenuate cell damage caused by lipoteichoic acid (LTA) in embryonic rat heart cells (H9c2). Methods LTA-induced cell damage occurred in H9c2 cells and the protective effects of DHAG at different concentrations (1–10 µM) were assessed. Indicators of oxidative stress and inflammatory responses in H9c2 cells were measured. Results DHAG (1–10 µM) significantly attenuated LTA-induced damage in H9c2 cells, as evidenced by increased cell viability and mitochondrial membrane potential, decreased cytochrome c release and DNA fragmentation, inhibition of caspase-3 and -9 activity, and altered expression of apoptosis-related proteins. DHAG also decreased oxidative stress by increasing protein expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Furthermore, DHAG inhibited inflammatory responses by decreasing protein expression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs). Conclusion DHAG exerted protective effects against LTA-induced cell damage, at least partially by decreasing oxidative stress and inhibiting inflammatory responses. Our results provide a scientific rational for developing DHAG as a therapy against infectious endocarditis.

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Section: Introductionmentioning

confidence: 57%

“…DHAG was provided by Prof. Teng from Zhengzhou University. 15 All solvents and chemicals were analytical grade and were purchased from Sinopharm Chemical Reagent Co. Ltd. (Shanghai, China). LTA and DHAG were dissolved in dimethyl sulfoxide (DMSO).…”

Section: Methodsmentioning

confidence: 99%

(Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside attenuates lipoteichoic acid-induced damage in rat cardiomyoblast cells

Song

Xie

et al. 2020

J Int Med Res

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“…Wu and colleagues observed that the novel (Z)-7,4 -dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside (196) isolated from the endophytic fungus Penicillium citrinum of the mangrove Bruguiera gymnorrhyza derivative decreased 1-methyl-4-phenylpyridium-induced neurotoxicity in rat pheochromocytoma PC12 cells in vitro by a mechanism that elevated mitochondrial membrane potential, decreased DNA fragmentation, and inhibited apoptosis [212].…”

Section: Marine Compounds Affecting the Nervous Systemmentioning

confidence: 99%

“…In contrast to the marine compounds affecting the nervous system with investigated mechanisms of action discussed above, and as shown in Table 2, for marine compounds (120, 121, 212-218), only an IC 50 was reported, but the molecular mechanism of action of these compounds remained undetermined at the time of publication: an Australian marine-sponge Aplysinella sp.-derived aplysinellamide-1 (212) [229], the novel lactones territrem D, and arisugacin A (120, 121) from a fungus Aspergillus terreus SCSGAF0162 derived from a South China sea gorgonian Echinogorgia aurantiaca [115]; an Indian marine cone snail Conus araneosus ar3j peptide (213) [230]; a new steroid (214) from a fungus Dichotomomyces cejpii isolated from an Australian marine sponge Callyspongia cf. C. flammea [231]; a novel genuanine (215) isolated from Cape Verde marine cone snail Conus genuanus [232]; a bromotyrosine alkaloid homoaerothionin (216) isolated from the Thai sponge Acanthodendrilla sp.…”

Section: Marine Compounds Affecting the Nervous Systemmentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

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The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

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“…Chemical substances can be produced by the endophytic fungi to protect the host plants from insects and other animals in the environment [4]. The endophytic fungi are recently considered as a source of bioactive compounds, which possess unique structures and have specific biological activities such as antimicrobial, antiviral, anticancer, antioxidant, neuroprotective, and antifungal activities [5][6][7][8][9], in drug discovery and development.…”

Section: Introductionmentioning

confidence: 99%

A New Polyketide from the Endophytic Fungus <i>Penicillium chermesinum</i>

et al. 2017

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Neuroprotective metabolites from the endophytic fungus Penicillium citrinum of the mangrove Bruguiera gymnorrhiza

Cited by 37 publications

References 17 publications

(Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside attenuates lipoteichoic acid-induced damage in rat cardiomyoblast cells

(Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside attenuates lipoteichoic acid-induced damage in rat cardiomyoblast cells

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

A New Polyketide from the Endophytic Fungus <i>Penicillium chermesinum</i>

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