2019
DOI: 10.1016/j.etap.2019.103224
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Neuroprotective role of naringenin against methylmercury induced cognitive impairment and mitochondrial damage in a mouse model

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Cited by 27 publications
(18 citation statements)
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“…The protective effect against metabolic diseases of naringenin is supported by its ability to scavenging some free radicals, by its ability to induce antioxidant enzymes and targeting on phosphoinositide 3-kinase/protein Kinase B/nuclear factors [38]. These mechanisms are involved in the neuroprotective effect recently reported by Chandran et al [45].…”
Section: Phenolics Content Zprementioning
confidence: 87%
“…The protective effect against metabolic diseases of naringenin is supported by its ability to scavenging some free radicals, by its ability to induce antioxidant enzymes and targeting on phosphoinositide 3-kinase/protein Kinase B/nuclear factors [38]. These mechanisms are involved in the neuroprotective effect recently reported by Chandran et al [45].…”
Section: Phenolics Content Zprementioning
confidence: 87%
“…In other studies, the ability of methyl mercury (MeHg) has been reported in the induction of severe mitochondrial dysfunction, oxidative insult, and neuronal damage, which ultimately coupled with memory and cognitive deficit [128,129,130]. Pretreatment with naringenin reversed MeHg-induced pyramidal cell damage, mitigated oxidative stress condition (confirmed by a significant increase in GSH, and GST accompanied with a marked decrease in MDA and protein carbonyl level) and ameliorated mitochondrial dysfunction (as indicated by preservation activities of mitochondrial complex I–IV and abrogation of lesions /10kb) [131].…”
Section: Naringenin In Neurodegenerative Diseasesmentioning
confidence: 99%
“…Naringenin is one of the most important natural flavonoid and has been recognized as a neuroprotective product (Krishna Chandran, Christina, Das, Mumbrekar, & Satish Rao, 2019). The cognitive and memory improvement effects of naringenin have also been proved in various animal models, except aging models.…”
Section: Discussionmentioning
confidence: 99%