Neuropsychiatric Symptoms in Parkinson Disease and Dementia with Lewy Bodies: What Geriatric Psychiatry Can Learn

Weintraub, Daniel

doi:10.1016/j.jagp.2013.02.020

Cited by 5 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A variety of neuropsychiatric symptoms (NPS), including depression, anxiety, hallucinations, apathy, and impulse control disorders, occur in up to 60% of PD patients . NPS have a significant impact on patients and their caregivers, as well as on the health care system . However, they are underrecognized and undertreated overall, due to patient‐related factors (e.g., incomplete understanding of mental health problems), access‐to‐care issues, and lack of interest and knowledge among clinicians …”

mentioning

confidence: 99%

“…1 NPS have a significant impact on patients and their caregivers, as well as on the health care system. 2 However, they are underrecognized and undertreated overall, 3 due to patient-related factors (e.g., incomplete understanding of mental health problems), access-to-care issues, and lack of interest and knowledge among clinicians. 3,4 Although little is known regarding causal factors, phenotypic variation suggests that a variety of factors contribute to NPS in PD.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Psychiatric issues in cognitive impairment

2014

Self Cite

View full text Add to dashboard Cite

Neuropsychiatric symptoms (NPS) such as depression, hallucinations and apathy commonly occur in Parkinson’s disease (PD) and have major clinical consequences including a negative impact on quality of life. This review discusses the epidemiology, clinical features, diagnostic procedures and treatment issues of NPS in PD and related disorders in the perspective of cognitive impairment, focusing on depression, anxiety, visual hallucinations, apathy, sleep disturbances, impulse control disorder and non-motor fluctuations. The majority of NPS are more common in PD patients with dementia, possibly related to shared underlying pathologies. Recent studies also suggest that NPS are associated with mild cognitive impairment in PD, in particular with the amnestic type. Accurate diagnosis of NPS is important but can be difficult, due to overlapping symptoms and similar appearance of symptoms of motor symptoms of parkinsonism, cognitive impairment, mood disorders and apathy. There are few systematic studies focusing on the management of NPS in PD with cognitive impairment.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Psychiatric issues in cognitive impairment

2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some people experience depressive syndromes before the onset of motor symptoms; others develop psychiatric symptoms or syndromes simultaneously or after the beginning of motor symptoms. Others may develop iatrogenic behavioral disorders, such as dopaminergic dysregulation syndrome, punding associated with levodopa, and impulse control disorders underlying dopamine agonist intake [ 7 , 8 ]. In this case, the clinician must know about pathological gambling, buying, collecting, and excessive eating, and their differential diagnoses.…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive Psychiatric and Neuropsychological Alterations in Parkinson’s Disease: A Basic and Clinical Approach

et al. 2023

View full text Add to dashboard Cite

The main histopathological hallmarks of Parkinson’s disease (PD) are the degeneration of the dopaminergic neurons of the substantia nigra pars compacta and the loss of neuromelanin as a consequence of decreased dopamine synthesis. The destruction of the striatal dopaminergic pathway and blocking of striatal dopamine receptors cause motor deficits in humans and experimental animal models induced by some environmental agents. In addition, neuropsychiatric symptoms such as mood and anxiety disorders, hallucinations, psychosis, cognitive impairment, and dementia are common in PD. These alterations may precede the appearance of motor symptoms and are correlated with neurochemical and structural changes in the brain. This paper reviews the most crucial pathophysiology of neuropsychiatric alterations in PD. It is worth noting that PD patients have global task learning deficits, and cognitive functions are compromised in a way is associated with hypoactivation within the striatum, anterior cingulate cortex, and inferior frontal sulcus regions. An appropriate and extensive neuropsychological screening battery in PD must accurately assess at least five cognitive domains with some tests for each cognitive domain. This neuropsychological screening should consider the pathophysiological and clinical heterogeneity of cognitive dysfunction in PD.

show abstract