Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study

Engelborghs, Sebastiaan; Maertens, Karen; Nagels, Guy; Vloeberghs, Ellen; Mariën, Peter; Symons, A.; Ketels, V.; Estercam, Sven; Somers, Nore; Deyn, Peter Paul De

doi:10.1002/gps.1395

Cited by 108 publications

(97 citation statements)

References 35 publications

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“…night time awakening, inability to sleep in night with frequent wandering and early morning awakening were also common. These are in consonance with earlier studies [13][14][15][16] .…”

Section: Discussionsupporting

confidence: 93%

Behavioural and Psychological Symptoms in Dementia (BPSD) and Its Impact on Caregiver Burden

Yahya¹

2018

jmscr

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“…night time awakening, inability to sleep in night with frequent wandering and early morning awakening were also common. These are in consonance with earlier studies [13][14][15][16] .…”

Section: Discussionsupporting

confidence: 93%

Behavioural and Psychological Symptoms in Dementia (BPSD) and Its Impact on Caregiver Burden

Yahya¹

2018

jmscr

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“…Informants indicate whether change is present or absent; however, there is no consideration of the degree of change. A structured and more sophisticated interview such as the Neuroticism Extroversion Openness-Personality Inventory (NEO-PI), [35][36][37] Neuropsychiatric Invento- ry, 38,39 or the BEHAVE-AD 40 might yield more detailed and comprehensive information regarding what facets of personality change first and what degree of change is indicative of dementia. The sample was not population-based, and thus we cannot directly compare our findings with epidemiologic data.…”

Section: Dlb Vs Ad Ever Present During Longitudinal Follow-upmentioning

confidence: 99%

Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease

Galvin¹,

Malcom²,

Johnson³

et al. 2007

Neurology

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Objective: To identify personality traits that distinguish dementia with Lewy bodies (DLB) from Alzheimer disease (AD). Methods: We examined 290 participants enrolled in a longitudinal study (nondemented control ϭ 34, DLB ϭ 128, AD ϭ 128) followed to autopsy. As part of the annual interview with the collateral source, the clinician asked about specific changes in personality, interests, and drives based on items from the Blessed Dementia Scale (BDS). Statistical analysis was performed using 2 and Fisher exact tests. Factor analysis was performed to determine underlying structure and receiver operating characteristic curves assessed the ability for each of three derived factors to discriminate DLB from AD. Results: The sample was evaluated for a mean of 4.8 visits (range 1 to 14) with a mean age of 77.6 Ϯ 9.9 years. The participants' cognitive status ranged from nondemented (Clinical Dementia Rating [CDR] 0) through all stages of dementia (CDR Ն 0.5). Personality traits that distinguished DLB included diminished emotional responsiveness (p ϭ 0.004), relinquishing hobbies (p ϭ 0.01), growing apathy (p ϭ 0.03), and purposeless hyperactivity (p ϭ 0.003).Factor analyses of the BDS revealed a PASSIVE factor (diminished emotional responsiveness, relinquished hobbies, growing apathy, and purposeless hyperactivity) explaining 10.4% of variance and that DLB was more likely to manifest these personality traits than AD (p ϭ 0.001). The PASSIVE factor discriminated DLB from AD (area under the curve ϭ 0.61, 95% CI: 0.54 to 0.68, p ϭ 0.006).Any change in personality is associated with the presence of visual hallucinations. Conclusions: Our results suggest that incorporating a brief, simple inventory of personality traits may improve the identification of individuals with dementia with Lewy bodies. NEUROLOGY 2007;68: [1895][1896][1897][1898][1899][1900][1901] Identifying the earliest features of dementia enables clinicians to implement therapy as soon as possible and provides patients and families more time to plan for the accompanying progressive decline. Much effort has focused on the cognitive symptoms of dementia syndromes such as impairments in memory, visuospatial, attention, and executive function. An alternative approach to improve early detection is to study noncognitive symptoms such as behavioral and personality changes that may precede diagnosis or occur early in the course of the dementia.

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“…Behavioural and psychological symptoms of dementia (BPSD) affect the majority of patients at same point in the progression of the disease (Lyketsos et al, 2002;Engelborghs et al, 2005). These BPSD occur in a dynamic process involving the patient, the family caregiver and their environment.…”

Section: Introductionmentioning

confidence: 99%

Influence of personality on caregiver's burden, depression and distress related to the BPSD

Melo

Marôco

Mendonça

2011

Int J Geriat Psychiatry

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Objective: We hypothesize that the personality influences the caregiver's depression, burden and distress related to BPSD. Subjects and methods: Participants were 105 consecutive patients with dementia and their family caregivers, living at home, attending a Dementia Clinic. A cross-sectional design was used with an applied a structured interview at home. Comprehensive assessments included: personality (NEO-FFI), burden (ZBI), depression (CES-D) and distress related to BPSD (NPI-distress). Statistical Path analysis was used to study the hypothetical causal and mediating effects between independent and criterion variables. Results: Neuroticism increased, whereas extraversion decreased, both caregiver's depression and burden. Agreeableness was also found to decrease the burden. The personality characteristics only indirectly influenced the caregiver's distress related to BPSD. Conclusion: These results reinforce the importance of including personality as an individual resource of the caregiver in the conceptual models and research on caregiving. Assessment of caregiver's personality characteristics should be taken into account for the planning of intervention programs.

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Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study

Cited by 108 publications

References 35 publications

Behavioural and Psychological Symptoms in Dementia (BPSD) and Its Impact on Caregiver Burden

Behavioural and Psychological Symptoms in Dementia (BPSD) and Its Impact on Caregiver Burden

Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease

Influence of personality on caregiver's burden, depression and distress related to the BPSD

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