Neuropsychological and positron emission tomography correlates in idiopathic environmental intolerances

Bornschein, Susanne; Hausteiner, Constanze; Drzezga, Alexander; Theml, Tina; Heldmann, Barbara; Grimmer, Timo; Perneczky, Robert; Jähn, Thomas; Schwaiger, Markus; Zilker, Thomas; Förstl, Hans

doi:10.5271/sjweh.1164

Cited by 10 publications

(7 citation statements)

References 42 publications

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“…Beside specific questions about exposure to chemicals and related symptoms, 51 – 92 some studies 51 – 53 , 58 , 59 , 62 – 65 , 68 , 71 , 75 – 77 , 79 , 80 , 82 , 83 , 86 , 88 , 90 , 92 have carried out questionnaires to assess the psychological condition (DSM-IV, SCL 90, NEO, CIDI, etc). Sociodemographic surveys have also been performed and surveys on the simultaneous presence of other diseases such as asthma, allergies, cardiorespiratory problems, autoimmune diseases, cancer, etc.…”

Section: Resultsmentioning

confidence: 99%

“…According to psychiatric and psychological test results, some authors have detected a frequent association between levels of anxiety, depression, psychotic disorders, and MCS, 50 , 58 , 59 , 64 , 71 , 75 – 77 , 80 , 82 , 83 , 86 , 88 results that led some of them to suppose that both stress 50 , 58 , 59 , 75 , 77 and/or female gender 50 may represent risk factors. An increase in the prevalence of other diseases in cases versus controls was also detected: asthma, allergies, atopic dermatitis, autoimmune, neurological, gynecological, cardiopulmonary diseases, etc.…”

Section: Resultsmentioning

confidence: 99%

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Multiple Chemical Sensitivity

Rossi

Pitidis

2018

Journal of Occupational &Amp; Environmental Medicine

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Objective:Systematic bibliography analysis of about the last 17 years on multiple chemical sensitivity (MCS) was carried out in order to detect new diagnostic and epidemiological evidence. The MCS is a complex syndrome that manifests as a result of exposure to a low level of various common contaminants. The etiology, diagnosis, and treatment are still debated among researchers.Method:Querying PubMed, Web of Science, Scopus, Cochrane library, both using some specific MESH terms combined with MESH subheadings and through free search, even by Google.Results:The studies were analyzed by verifying 1) the typology of study design; 2) criteria for case definition; 3) presence of attendances in the emergency departments and hospital admissions, and 4) analysis of the risk factors.Outlook:With this review, we give some general considerations and hypothesis for possible future research.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Multiple Chemical Sensitivity

Rossi

Pitidis

2018

Journal of Occupational &Amp; Environmental Medicine

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“…Importantly, more sophisticated imaging studies of MCS patients, such as PET studies using ligands to acetylcholinesterase and other neurochemicals potentially impacted by environmental toxicants, are needed to empirically define the influences of MCS on brain function. A number of authors have outlined needed study designs that have yet to be implemented to test specific hypotheses of illnesses induced by low levels of environmental chemicals (e.g., [ 63 , 191 ]), and it would seem prudent that future researchers carefully study their recommendations.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Andersson et al, [ 188 ] observed limbic hyperactivity in an fMRI study of IEI patients exposed to low levels of olfactory and trigeminal stimuli. However, in contrast to these findings, two PET studies of 12 MCS patients found no meaningful resting functional imaging brain patterns specific to MCS [ 189 , 190 , 191 ].…”

Section: Biological Theories Of Mcsmentioning

confidence: 97%

Multiple Chemical Sensitivity

Zucco

Doty

2021

Brain Sciences

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Multiple Chemical Sensitivity (MCS), a condition also known as Chemical Sensitivity (CS), Chemical Intolerance (CI), Idiopathic Environmental Illness (IEI) and Toxicant Induced Loss of Tolerance (TILT), is an acquired multifactorial syndrome characterized by a recurrent set of debilitating symptoms. The symptoms of this controversial disorder are reported to be induced by environmental chemicals at doses far below those usually harmful to most persons. They involve a large spectrum of organ systems and typically disappear when the environmental chemicals are removed. However, no clear link has emerged among self-reported MCS symptoms and widely accepted objective measures of physiological dysfunction, and no clear dose-response relationship between exposure and symptom reactions has been observed. In addition, the underlying etiology and pathogenic processes of the disorder remain unknown and disputed, although biologic and psychologic hypotheses abound. It is currently debated whether MCS should be considered a clinical entity at all. Nevertheless, in the last few decades MCS has received considerable scientific and governmental attention in light of the many persons reporting this illness. In this review, we provide a general overview of the history, definition, demographics, prevalence, and etiologic challenges in defining and understanding MCS.

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“…On the other hand, while Herr et al reported more noticeable changes in physiological parameters for patients with environment‐related problems, they could also show that higher somatic complaints were only found for persons who were actually exposed to noxious agents. Regarding cognitive performance, Bornschein et al observed no differences between IEI/MCS patients and healthy controls. Finally, Dalton and Dalton and Jaén showed experimentally that even in healthy persons complaints and performance losses could be induced by priming certain odors as dangerous.…”

Section: Introductionmentioning

confidence: 96%

Psychological and cognitive effects of laser printer emissions: A controlled exposure study

et al. 2017

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The possible impact of ultrafine particles from laser printers on human health is controversially discussed although there are persons reporting substantial symptoms in relation to these emissions. A randomized, single-blinded, cross-over experimental design with two exposure conditions (high-level and low-level exposure) was conducted with 23 healthy subjects, 14 subjects with mild asthma, and 15 persons reporting symptoms associated with laser printer emissions. To separate physiological and psychological effects, a secondary physiologically based categorization of susceptibility to particle effects was used. In line with results from physiological and biochemical assessments, we found no coherent, differential, or clinically relevant effects of different exposure conditions on subjective complaints and cognitive performance in terms of attention, short-term memory, and psychomotor performance. However, results regarding the psychological characteristics of participants and their situational perception confirm differences between the participants groups: Subjects reporting symptoms associated with laser printer emissions showed a higher psychological susceptibility for adverse reactions in line with previous results on persons with multiple chemical sensitivity or idiopathic environmental intolerance. In conclusion, acute psychological and cognitive effects of laser printer emissions were small and could be attributed only to different participant groups but not to differences in exposure conditions in terms of particle number concentrations. K E Y W O R D Scognitive performance, exposure, idiopathic environmental intolerance, laser printer emission, multiple chemical sensitivity, subjective complaints

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Neuropsychological and positron emission tomography correlates in idiopathic environmental intolerances

Cited by 10 publications

References 42 publications

Multiple Chemical Sensitivity

Multiple Chemical Sensitivity

Multiple Chemical Sensitivity

Psychological and cognitive effects of laser printer emissions: A controlled exposure study

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