Neuropsychological Assessment of Adult Patients with Shunted Hydrocephalus

Bakar, Emel Erdoğan; Bakar, Bülent

doi:10.3340/jkns.2010.47.3.191

Cited by 15 publications

(4 citation statements)

References 24 publications

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“…The serial digit learning tests (SDL Test) is useful in evaluating cognitive processing, such as learning and short term memory, and it has been used in various disease groups, like depression and hydrocephaly (Bakar and Bakar 2010;Demir et al 2013). This test has also been used in OSAS to assess cognitive function.…”

Section: Discussionmentioning

confidence: 99%

The effect of nasal polyposis related nasal obstruction on cognitive functions

et al. 2018

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Chronic rhinosinusitis with nasal polyposis is a chronic inflammatory disease of the respiratory mucosa of the nasal cavity and paranasal sinuses. The aim of this study was investigate the effect of nasal obstruction related to chronic rhinosinusitis with nasal polyposis on cognitive functions. Patients with chronic rhinosinusitis with nasal polyposis causing bilateral total or near total nasal obstruction were enrolled in the study. Symptoms of nasal congestion, loss of smell, postnasal drip, headaches, snoring, concentration difficulties and blunted affect were evaluated by Visual Analog Scale. Brief symptom inventory test, Stroop test, visual aural digit span, serial digit learning test and P300 test were used to evaluate cognitive functions. Three months after treatment, the tests done before surgery were repeated and the results were compared. A total of 30 patients were included in the study. On the Visual Analog Scale, all symptoms showed significant postoperative improvement in all patients ( < 0.001 for all symptoms). Preoperative nasal congestion accompanied with impaired concentration were detected in 27 patients (90%), and these symptoms recovered in all these patients after treatment ( = 0.035) (correlation coefficient 0.4). Only 22 patients completed the neuropsychological tests. The mean preoperative Stroop test (23.16 ± 5.30), visual aural digit span test (24.68 ± 3.52), and serial digit learning test (16.18 ± 5.35) scores were showed significant improvement compared with mean postoperative Stroop test (21.12 ± 5.69), visual aural digit span test (26.45 ± 2.98), and serial digit learning test (19.31 ± 4.47) scores ( = 0.047, = 0.022, = 0.005 respectively). The postoperative P300 latency values improved in 19 (63%) patients. The preoperative and postoperative latency values for P300 showed a significant difference ( = 0.029), whereas the preoperative and postoperative amplitude values for P300 did not differ ( = 0.096). In conclusion, the results of this study indicate that chronic rhinosinusitis with nasal polyposis (CRSwNP) has negative effects on cognitive functions, such as the ability to focus and maintain concentration. These cognitive functions improve after the patients undergo endoscopic sinus surgery to treat their CRSwNP.

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Section: Discussionmentioning

confidence: 99%

The effect of nasal polyposis related nasal obstruction on cognitive functions

et al. 2018

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“…The Bender-Gestalt test was administered mainly to evaluate visuomotor integration skills. The total score was determined using the scoring system of Bakar and Bakar [42 ]and Lacks and Newport [43]. …”

Section: Methodsmentioning

confidence: 99%

Cognitive Impairment in Native Chinese with Spinocerebellar Ataxia Type 3

Chen

Hou

et al. 2014

Eur Neurol

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Background: Previous studies have shown cognitive impairment in patients with spinocerebellar ataxia type 3 (SCA3). However, there is a lack of data on Chinese patients with SCA3. Method: We investigated 22 native Chinese with SCA3 and 18 controls matched for age, education as well as mental status. Cognitive assessments were carefully carried out to measure verbal fluency, memory, attention, executive function, visuospatial and visuoconstructive functions. Results: The most common impairments of cognition in native Chinese with SCA3 were disruption of phonemic verbal fluency and frontal executive dysfunction. Deficits in semantic fluency were detected in about 31.8% patients. Impaired visuospatial function and verbal memory were also found in native Chinese with SCA3. The degree of ataxia, CAG repeat length and education were found to correlate with cognitive performance. Multivariate binary logistic regression suggested that an oculomotor disorder and depression are predictors of cognitive impairment. Conclusion: Native Chinese with SCA3 had cognitive impairment of frontal executive function, temporal and parietal functions. An oculomotor disorder might be an index of cognitive dysfunction.

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“…In our study, we also found hypoactivity, reduced rotarod performance and a loss of body weight in mice immediately prior to death. In humans, gait abnormalities, motor disorders and memory and cognitive deficits are the most common behavioral changes; however, these behavioral deficits are associated with overt hydrocephalus and are likely due to the compression of brain tissue (e.g., the cortex, hippocampus and cerebellum) that is common with severe hydrocephalus [52] – [56] .…”

Section: Discussionmentioning

confidence: 99%

Morphological and Behavioral Changes in the Pathogenesis of a Novel Mouse Model of Communicating Hydrocephalus

2012

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The Ro1 model of hydrocephalus represents an excellent model for studying the pathogenesis of hydrocephalus due to its complete penetrance and inducibility, enabling the investigation of the earliest cellular and histological changes in hydrocephalus prior to overt pathology. Hematoxylin and eosin staining, immunofluorescence and electron microscopy were used to characterize the histopathological events of hydrocephalus in this model. Additionally, a broad battery of behavioral tests was used to investigate behavioral changes in the Ro1 model of hydrocephalus. The earliest histological changes observed in this model were ventriculomegaly and disorganization of the ependymal lining of the aqueduct of Sylvius, which occurred concomitantly. Ventriculomegaly led to thinning of the ependyma, which was associated with periventricular edema and areas of the ventricular wall void of cilia and microvilli. Ependymal denudation was subsequent to severe ventriculomegaly, suggesting that it is an effect, rather than a cause, of hydrocephalus in the Ro1 model. Additionally, there was no closure of the aqueduct of Sylvius or any blockages within the ventricular system, even with severe ventriculomegaly, suggesting that the Ro1 model represents a model of communicating hydrocephalus. Interestingly, even with severe ventriculomegaly, there were no behavioral changes, suggesting that the brain is able to compensate for the structural changes that occur in the pathogenesis of hydrocephalus if the disorder progresses at a sufficiently slow rate.

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Neuropsychological Assessment of Adult Patients with Shunted Hydrocephalus

Cited by 15 publications

References 24 publications

The effect of nasal polyposis related nasal obstruction on cognitive functions

The effect of nasal polyposis related nasal obstruction on cognitive functions

Cognitive Impairment in Native Chinese with Spinocerebellar Ataxia Type 3

Morphological and Behavioral Changes in the Pathogenesis of a Novel Mouse Model of Communicating Hydrocephalus

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