Neuropsychological comparison of incident MCI and prevalent MCI

Hansen, Allison L.; Caselli, Richard J.; Schlosser-Covell, G.; Golafshar, Michael A.; Dueck, Amylou C.; Woodruff, Bryan K.; Stonnington, Cynthia M.; Geda, Yonas E.; Locke, Dona E.C.

doi:10.1016/j.dadm.2018.08.009

Cited by 4 publications

(6 citation statements)

References 27 publications

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“…The difficulties found in Language and the global score on the ACE-R did not differ from those attained by the PD-MCI group, but were both worse than the performance shown by the control group. The results obtained support the presence of a continuum of cognitive function within the concept of MCI, even when the main impairment affects memory 2…”

Section: Discussionsupporting

confidence: 70%

“…The three groups were compared using one-way analysis of variance and post-hoc comparisons using the Tukey HSD test. Effect sizes were calculated using partial eta squared (η2 partial ). Cohen classifies .01 as a small effect, .06 as a medium effect and .14 as a large effect 29…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of MCI ranges from 7 to 47.9%, with a worldwide average prevalence of 18.9 per 1000 population 1. Previous studies have shown that the annual conversion rate from MCI to Alzheimer disease (AD) was 10-15% and that approximately 50% of MCI patients will convert to AD within 4 years 2. Therefore, MCI is considered a transition phase from normal aging to AD 2…”

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confidence: 99%

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Clinical utility of the INECO Frontal Screening for detecting Mild Cognitive Impairment in Parkinson’s disease

Broche-Pérez

Bartuste-Marrer²,

Batule-Domínguez³

et al. 2019

Dement. neuropsychol.

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Cognitive deficits in Parkinson’s disease typically affect executive functions. Recently, the concept of Mild Cognitive Impairment (MCI) has been related to PD (PD-MCI). PD-MCI is considered a transition phase to Parkinson’s disease Dementia. Therefore, it is important to identify PD-MCI in a reliable way. Objective: To evaluate the sensitivity and specificity of the INECO Frontal Screening (IFS) in detecting cognitive deficits in PD-MCI. Additionally, we compare the IFS and the Addenbrook Cognitive Examination Revised (ACE-R) between three groups; PD-MCI, MCI, and controls. Methods: The IFS and ACE-R were administered to 36 patients with PD-MCI, 31 with MCI (amnestic-multidomain subtype) and 92 healthy controls. Sensitivity and specificity were determined using ROC analysis. The groups were compared using one-way analysis of variance. Results: The IFS had adequate accuracy in differentiating patients with PD-MCI from healthy controls (AUC=0.77, sensitivity=0.82, specificity=0.77), and good accuracy in differentiating PD-MCI from MCI patients (AUC=0.80, sensitivity=0.82, specificity=0.61). However the IFS had low accuracy in differentiating MCI patients from healthy controls (AUC=0.47, sensitivity=0.52, specificity=0.41). On the ACE-R, the PD-MCI group had low performance in Fluency and Language. Only patients with PD-MCI had difficulties on the IFS, specifically in inhibitory control and visual working memory. This dysexecutive profile explains the sensitivity and specificity values found in the IFS. Conclusion: The present study results suggest that the IFS is a suitable screening tool for exploring cognitive dysfunction in PD-MCI, especially in those patients with a dysexecutive profile.

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Section: Discussionsupporting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical utility of the INECO Frontal Screening for detecting Mild Cognitive Impairment in Parkinson’s disease

Broche-Pérez

Bartuste-Marrer²,

Batule-Domínguez³

et al. 2019

Dement. neuropsychol.

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“…M ild cognitive impairment (MCI) is considered a transition phase between normal cognition and Alzheimer's disease (AD). 1 The prevalence of MCI in people aged over 65 years ranges from 7 to 47.9%, with a global prevalence of 18.9% per one thousand people. 2 MCI patients can be classified in two main categories: amnestic MCI (aMCI), if patients show a poor performance on the episodic memory test, but functioning in other cognitive domains is preserved; and non-amnestic MCI (naMCI), if patients show a poor performance on cognitive evaluation covering domains other than memory such as language, visuospatial abilities, or executive functions.…”

Section: Introductionmentioning

confidence: 99%

“…4 Approximately 50% of people with MCI will be diagnosed with AD in the following 4 years. 1 . However, the specific conversion prognoses for each subtype may differ.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of sensitivity and specificity of the INECO Frontal Screening and the Frontal Assessment Battery in mild cognitive impairment

Fernández-Fleites

Jiménez-Puig

Broche-Pérez

et al. 2021

Dement. neuropsychol.

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ABSTRACT. The Frontal Assessment Battery (FAB) and the INECO Frontal Screening (IFS) are two instruments frequently used to explore cognitive deficits in different diseases. However, studies reporting their use in patients with mild cognitive impairment (MCI) are limited. Objective: To compare the sensitivity and specificity of FAB and IFS in mild cognitive impairment (multiple-domain amnestic MCI subtype — md-aMCI). Methods: IFS and FAB were administered to 30 md-aMCI patients and 59 healthy participants. Sensitivity and specificity were investigated using the Receiver Operating Characteristic (ROC) analysis. Results: The area under the ROC curve (AUC) of IFS for MCI patients was .82 (sensitivity=0.96; specificity=0.76), whereas the AUC of FAB was 0.74 (sensitivity=0.73; specificity=0.70). Conclusions: In comparison to FAB, IFS showed higher sensitivity and specificity for the detection of executive dysfunctions in md-aMCI subtype. The use of IFS in everyday clinical practice would allow detecting the frontal dysfunctions in MCI patients with greater precision, enabling the early intervention and impeding the transition to more severe cognitive alterations.

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Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review

et al. 2023

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Mild cognitive impairment (MCI), representing the ‘transitional zone’ between normal cognition and dementia, has become a novel topic in clinical research. Although early detection is crucial, it remains logistically challenging at the same time. While traditional pen-and-paper tests require in-depth training to ensure standardized administration and accurate interpretation of findings, significant technological advancements are leading to the development of procedures for the early detection of Alzheimer’s disease (AD) and facilitating the diagnostic process. Some of the diagnostic protocols, however, show significant limitations that hamper their widespread adoption. Concerns about the social and economic implications of the increasing incidence of AD underline the need for reliable, non-invasive, cost-effective, and timely cognitive scoring methodologies. For instance, modern clinical studies report significant oculomotor impairments among patients with MCI, who perform poorly in visual paired-comparison tasks by ascribing less attentional resources to novel stimuli. To accelerate the Global Action Plan on the Public Health Response to Dementia 2017–2025, this work provides an overview of research on saccadic and exploratory eye-movement deficits among older adults with MCI. The review protocol was drafted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Electronic databases were systematically searched to identify peer-reviewed articles published between 2017 and 2022 that examined visual processing in older adults with MCI and reported gaze parameters as potential biomarkers. Moreover, following the contemporary trend for remote healthcare technologies, we reviewed studies that implemented non-commercial eye-tracking instrumentation in order to detect information processing impairments among the MCI population. Based on the gathered literature, eye-tracking-based paradigms may ameliorate the screening limitations of traditional cognitive assessments and contribute to early AD detection. However, in order to translate the findings pertaining to abnormal gaze behavior into clinical applications, it is imperative to conduct longitudinal investigations in both laboratory-based and ecologically valid settings.

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Neuropsychological comparison of incident MCI and prevalent MCI

Cited by 4 publications

References 27 publications

Clinical utility of the INECO Frontal Screening for detecting Mild Cognitive Impairment in Parkinson’s disease

Clinical utility of the INECO Frontal Screening for detecting Mild Cognitive Impairment in Parkinson’s disease

Evaluation of sensitivity and specificity of the INECO Frontal Screening and the Frontal Assessment Battery in mild cognitive impairment

Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review

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