Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia

Ossa, César Argumedos De la; Ramírez-Giraldo, Andrés Fernando; Arroyo-Alvis, Katy; Marrugo‐Negrete, José; Dı́ez, Sergi

doi:10.1016/j.envres.2022.114467

Cited by 6 publications

(2 citation statements)

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“…The GSTP1 rs1695 AG genotype was previously associated (~4 fold) with the clinical signs of polyneuropathy in adults of the same ethnicity [ 15 ]. There is substantial evidence that high levels of Hg may be associated with neurological impairment in children [ 3 , 4 , 12 , 13 ] and that genetic polymorphisms can influence this association [ 12 , 25 , 48 , 51 ]. These findings highlight a public health concern and the need to monitor these children before they develop more serious health consequences.…”

Section: Discussionmentioning

confidence: 99%

“…People who live close to areas invaded by ASGM, mostly Amazonian indigenous peoples, are threatened by its harmful effects and are at risk of developing several health issues [ 8 , 9 , 10 ]. By causing neuropsychiatric damage, Hg exposure resulting from this activity has a direct impact on people’s quality of life [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. A recent study showed a tendency of worse mental health indicators in Munduruku indigenous people with elevated levels (≥6.0 µg/g) of MeHg exposure [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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The GSTP1 rs1695 Polymorphism Is Associated with Mercury Levels and Neurodevelopmental Delay in Indigenous Munduruku Children from the Brazilian Amazon

Silva,

Basta,

Hofer

et al. 2024

Toxics

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Genetic polymorphisms may influence mercury (Hg) toxicity. The aims of this study were to evaluate individual factors, such as the presence of the GSTP1 rs1695 polymorphism, associated with internal Hg dose and child neurodevelopment in indigenous people from the Brazilian Amazon chronically exposed to Hg. Eighty-two indigenous children were clinically evaluated, hair Hg was measured, and the GSTP1 rs1695 polymorphism was genotyped. The mean age was 4.8 years, the median Hg was 5.5 µg/g, and 93.8% of children exceeded the safe limit (2.0 µg/g). Fish consumption was associated with Hg levels (p = 0.03). The GSTP1 rs1695 A>G polymorphism was in the Hardy–Weinberg equilibrium and the highest prevalence of the GSTP1 AA genotype (80%) was found in Sawré Aboy, which had the highest Hg levels (10 µg/g) among the studied villages. The Hg levels tended to increase over the years in males and in carriers of the GSTP1 AA genotype (0.69 µg/g and 0.86 µg/g, respectively). Nine children failed the neurodevelopmental test, all of whom had Hg > 2.0 µg/g, and 88.9% carried the GSTP1 AA or AG genotypes, previously associated with the highest internal Hg doses and neurocognitive disorders. The genetic counseling of this population is important to identify the individuals at greater risk for neurodevelopmental disorders resulting from chronic Hg exposure.

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