Neuropsychological Effects of Chronic Methamphetamine Use on Neurotransmitters and Cognition: A Review

Nordahl, Thomas E.; Salo, Ruth; Leamon, Martin H.

doi:10.1176/jnp.15.3.317

Cited by 270 publications

(137 citation statements)

References 70 publications

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“…The means by which METH leads to CNS damage with cognitive and psychiatric disorders (Cadet et al, 2003;Nordahl et al, 2003) the degree of potential neurochemical and functional recovery from damage (Volkow et al, 2001;Wang et al, 2004) and its interactions with other pathogenic challenges, such as HIV infection (Rippeth et al, 2004) are still relatively unknown. The use of this experimental animal model will enable the study of the chronic effects of METH, as well as therapeutic means for their amelioration.…”

Section: Discussionmentioning

confidence: 99%

Modeling Human Methamphetamine Exposure in Nonhuman Primates: Chronic Dosing in the Rhesus Macaque Leads to Behavioral and Physiological Abnormalities

Madden

Flynn

Zandonatti

et al. 2004

Neuropsychopharmacol

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Acute high dose methamphetamine (METH) dosing regimens are frequently used in animal studies, however, these regimens can lead to considerable toxicity and even death in experimental animals. Acute high dosing regimens are quite distinct from the chronic usage patterns found in many human METH abusers. Furthermore, such doses, especially in nonhuman primates, can result in unexpected death, which is unacceptable, especially when such deaths fail to accurately model effects of human usage. As a model of chronic human METH abuse we have developed a nonlethal chronic METH administration procedure for the rhesus macaque that utilizes an escalating dose protocol. This protocol slowly increases the METH dosage from 0.1 to 0.7 mg/kg b.i.d. over a period of 4 weeks, followed by a period of chronic METH administration at 0.75 mg/kg b.i.d. ( ¼ total daily METH administration of 1.5 mg/kg). In parallel to human usage patterns, METH injections were given 20-23 times a month. This regimen produced a number of behavioral and physiological effects including decreased food intake and a significant increase in urinary cortisol excretion.

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Section: Discussionmentioning

confidence: 99%

Modeling Human Methamphetamine Exposure in Nonhuman Primates: Chronic Dosing in the Rhesus Macaque Leads to Behavioral and Physiological Abnormalities

Madden

Flynn

Zandonatti

et al. 2004

Neuropsychopharmacol

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“…Dopamine antagonists (like haloperidol) that affect the meso-striatal dopamine system slow down the clock rate in healthy subjects (Rammsayer, 1989; whereas timing behavior in animals and humans under the acute influence of METH can be interpreted as the result of speeding up the clock rate (Buhusi and Meck, 2002;Cevik, 2003;Mohs et al, 1980). Functional neuroimaging and neuropsychological studies show that chronic stimulant users have significant brain activation changes in frontostriatal regions that are associated with impairments in attention, working memory, and decision making (Fein et al, 2002: McKetin andMattick, 1997;Nordahl et al, 2003;O'Mally et al, 1992;Paulus et al 2003;Salo et al, 2005). Stimulant-using individuals and stimulant-dependent individuals (SDI) show fundamental cognitive deficits and increased impulsivity when making decisions (Leland and Paulus, 2005;Fillmore and Rush, 2002;Paulus et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Impaired time perception and motor timing in stimulant-dependent subjects

Wittmann

Leland

Churan

et al. 2007

Drug and Alcohol Dependence

152

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Stimulant-dependent individuals (SDI) have abnormal brain metabolism and structural changes involving dopaminergic target areas important for the processing of time. These individuals are also more impulsive and impaired in working memory and attention. The current study tested whether SDI show altered temporal processing in relation to impulsivity or impaired prefrontal cortex functioning. We employed a series of timing tasks aimed to examine time processing from the milliseconds to multiple seconds range and assessed cognitive function in 15 male SDI and 15 stimulant-naïve individuals. A mediation analysis determined the degree to which impulsivity or executive dysfunctions contributed to group differences in time processing. SDI showed several abnormal time processing characteristics. SDI needed larger time differences for effective duration discrimination, particularly for intervals of around 1 sec. SDI also accelerated finger tapping during a continuation period after a 1 Hz pacing stimulus was removed. In addition, SDI overestimated the duration of a relatively long time interval, an effect which was attributable to higher impulsivity. Taken together, these data show for the first time that SDI exhibit altered time processing in several domains, one which can be explained by increased impulsivity. Altered time processing in SDI could explain why SDI have difficulty delaying gratification.

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“…Several lines of evidence demonstrated that MAP dependence may cause long-term neural damage in humans, with concomitant deleterious effects on cognitive processes such as memory and attention (Nordahl et al, 2003), suggesting the possible role of BDNF secretion in the memory deficits of MAP abusers. The other SNP frequently analyzed is 132C>T in the noncoding region of exon V (GENBANK: AF411339; at position 53620).…”

Section: Introductionmentioning

confidence: 99%

Association study between brain‐derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan

Itoh

Hashimoto

Shimizu

et al. 2004

American J of Med Genetics Pt B

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Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C>T (C270T named formerly) in the noncoding region of exon V and 196G >A (val66met)

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Neuropsychological Effects of Chronic Methamphetamine Use on Neurotransmitters and Cognition: A Review

Cited by 270 publications

References 70 publications

Modeling Human Methamphetamine Exposure in Nonhuman Primates: Chronic Dosing in the Rhesus Macaque Leads to Behavioral and Physiological Abnormalities

Modeling Human Methamphetamine Exposure in Nonhuman Primates: Chronic Dosing in the Rhesus Macaque Leads to Behavioral and Physiological Abnormalities

Impaired time perception and motor timing in stimulant-dependent subjects

Association study between brain‐derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan

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