Neuropsychological Features of Progressive Supranuclear Palsy

Grafman, Jordan; Litvan, Irene; Stark, Marianna

doi:10.1006/brcg.1995.1260

Cited by 64 publications

(35 citation statements)

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“…Finally, realized treatment benefits may be short-lived because of a progressive dementia that is almost universal in typical PSP [7] but that occurs in less than half of PD patients [20]. The dementia of PSP patients typically includes impaired memory, and slowed, defective motor planning and execution [21]. Consequently, clinical dysphagia management may require more frequent but shortened sessions.…”

Section: Discussionmentioning

confidence: 99%

Dysphagia in Progressive Supranuclear Palsy: Radiologic Features

Leopold

Kagel

1997

Dysphagia

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Progressive supranuclear palsy (PSP) is a progressive degenerative extrapyramidal disease that often masquerades as Parkinson's disease (PD). Similar to PD, dysphagia frequently complicates the course of PSP. Because there is only one published report characterizing dysphagia in PSP, we reviewed the neurologic features and dynamic videofluoroscopic swallowing function study results in 10 dysphagic PSP patients. Abnormalities during multiple stages of ingestion were recorded in each patient. Uncoordinated lingual movements, absent velar retraction or elevation, impaired posterior lingual displacement, and copious pharyngeal secretions were noted in all patients. Tongue-assisted mastication, noncohesive lingual transfer, excessive oral bolus lingual leakage to the pharynx prior to active transfer, vallecular bolus retention, abnormal epiglottic positioning, and hiatal hernias were noted in at least half of the cohort. Although ingestion abnormalities in PSP are similar to those previously reported in PD, the number of studied patients and observed differences were too few to clearly differentiate the two diseases.

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Section: Discussionmentioning

confidence: 99%

Dysphagia in Progressive Supranuclear Palsy: Radiologic Features

Leopold

Kagel

1997

Dysphagia

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“…[40] As in CJD, PSP patients develop dementia, akinetic-rigid parkinsonism (symmetric bradykinesia and axial rigidity), postural instability, swallowing and speech problems, and often progress to a hypokinetic, mute state. [41][42][43][44][45][46] Abnormalities of eye movements, particularly slowed of velocity of saccades progressing to supranuclear gaze palsy, are part of the PSP syndrome. CJD mimicking PSP has been reported.…”

Section: Typically Chronic Degenerative Dementiasmentioning

confidence: 99%

Rapidly Progressive Dementia

2007

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Rapidly progressive dementias (RPDs) are neurological conditions that develop subacutely over weeks to months, or rarely acutely over days. In contrast to most dementing conditions that take years to progress to death, RPD can be quickly fatal. It is critical to evaluate the RPD patient without delay, usually in a hospital setting, as they may have a treatable condition. In this review, we discuss a differential diagnostic approach to RPD, emphasizing neurodegenerative, toxic/metabolic, infectious, autoimmune, neoplastic, and other conditions to consider.

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“…Cognitive impairment and dementia are frequently reported in PSP, and some evidence suggests that dementia is more common in PSP than in PD [9]. Although only small samples of PSP patients have been studied using reasonably comprehensive cognitive assessments, findings indicate prominent changes in visual attention, executive functions, memory, and psychomotor and information processing speed [10]. Behavioral disturbances, such as impulsivity, are also commonly reported.…”

Section: Progressive Supranuclear Palsymentioning

confidence: 99%

Cognitive impairment and dementia in basal ganglia disorders

Stout

Johnson

2005

Curr Neurol Neurosci Rep

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We present an update focusing on research from the past 2 years on cognitive impairment and dementia in basal ganglia disorders, including Huntington's disease, progressive supranuclear palsy, Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. In addition to the many recent papers that aim to refine descriptions of the cognitive phenotypes in the basal ganglia disorders, the current literature addresses the use of cognitive assessment in differential diagnosis of clinically overlapping disorders, the effects of surgical and pharmacologic treatments on cognitive functions, and the relationship between cognitive impairment and functional disability. We also discuss opportunities for enhancing the understanding of cognition in basal ganglia disorders through the use of improved study design and assessment strategies.

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Neuropsychological Features of Progressive Supranuclear Palsy

Cited by 64 publications

References 0 publications

Dysphagia in Progressive Supranuclear Palsy: Radiologic Features

Dysphagia in Progressive Supranuclear Palsy: Radiologic Features

Rapidly Progressive Dementia

Cognitive impairment and dementia in basal ganglia disorders

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