Neuropsychological, neuropsychiatric, and clinical correlates of affective and cognitive theory of mind in Parkinson’s disease: A meta-analysis.

Maggi, Gianpaolo; Muñoz, Amable Cima; Obeso, Ignacio; Santangelo, Gabriella

doi:10.1037/neu0000807

Cited by 20 publications

(7 citation statements)

References 114 publications

(219 reference statements)

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“…The alteration of both the Cognitive and the Affective subnetworks of ToM seems to suggest a widespread alteration of the although the Cognitive portion seems to be affected more consistently. Despite the absence of behavioural measures of ToM in the present study, the results at brain level appear to be in line with a concomitant impairment of Cognitive and Affective ToM (and their reciprocal connections) in the early stages of PD (Maggi et al, 2022;Santangelo et al, 2012). Functional connectivity changes in PD have been frequently described (Cerasa et al, 2016), yet mainly focusing on the sensorimotor network (Caspers et al, 2021;Tessitore et al, 2014).…”

Section: Discussionsupporting

confidence: 54%

Functional alterations in resting‐state networks for Theory of Mind in Parkinson's disease

Rabini,

Funghi,

Meli

et al. 2023

Eur J of Neuroscience

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In Parkinson's disease (PD), impairment of Theory of Mind (ToM) has recently attracted an increasing number of neuroscientific investigations. If and how functional connectivity of the ToM network is altered in PD is still an open question. First, we explored whether ToM network connectivity shows potential PD‐specific functional alterations when compared to healthy controls (HC). Second, we tested the role of the duration of PD in the evolution of functional alterations in the ToM network. Between‐group connectivity alterations were computed adopting resting‐state functional magnetic resonance imaging (rs‐fMRI) data of four groups: PD patients with short disease duration (PD‐1, n = 72); PD patients with long disease duration (PD‐2, n = 22); healthy controls for PD‐1 (HC‐1, n = 69); healthy controls for PD‐2 (HC‐2, n = 22). We explored connectivity differences in the ToM network within and between its three subnetworks: Affective, Cognitive and Core. PD‐1 presented a global pattern of decreased functional connectivity within the ToM network, compared to HC‐1. The alterations mainly involved the Cognitive and Affective ToM subnetworks and their reciprocal connections. PD‐2—those with longer disease duration—showed an increased connectivity spanning the entire ToM network, albeit less consistently in the Core ToM network, compared to both the PD‐1 and the HC‐2 groups. Functional connectivity within the ToM network is altered in PD. The alterations follow a graded pattern, with decreased connectivity at short disease duration, which broadens to a generalized increase with longer disease duration. The alterations involve both the Cognitive and Affective subnetworks of ToM.

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Section: Discussionsupporting

confidence: 54%

Functional alterations in resting‐state networks for Theory of Mind in Parkinson's disease

Rabini,

Funghi,

Meli

et al. 2023

Eur J of Neuroscience

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“…The influence of sex, the presence of hypertension, diabetes, RBD, and RLS, and the intake of DA, benzodiazepines, and antidepressants, reported as categorical variables (frequencies and percentages), was evaluated using risk ratio (RR). We used the random-effects model to estimate the meta-analytic results because of its appropriateness when there is variation in clinical or demographic characteristics of the sample [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…We used the random‐effects model to estimate the meta‐analytic results because of its appropriateness when there is variation in clinical or demographic characteristics of the sample [18–20].…”

Section: Methodsmentioning

confidence: 99%

Prevalence and clinical aspects of obstructive sleep apnea in Parkinson disease: A meta‐analysis

Maggi,

Giacobbe,

Iannotta

et al. 2023

Euro J of Neurology

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Background and PurposeObstructive sleep apnea (OSA) frequently occurs in Parkinson Disease (PD), probably caused by upper airway dysfunctions or shared pathogenetic mechanisms. OSA may precede PD diagnosis or worsen throughout its course, but its relationship with clinical features and dopaminergic medication remains unclear. This meta‐analysis aimed to provide a reliable estimate of OSA prevalence in the PD population (PD‐OSA) and to clarify its clinical associated factors to help clinicians in understanding the underlying pathophysiological mechanisms.MethodsA systematic literature search was performed up to April 2023 using the PubMed, Scopus, and PsycINFO databases. Articles were included if they provided data on PD patients with and without OSA. Pooled prevalence for PD‐OSA was calculated using the proportions of PD participants diagnosed with OSA. Demographic and clinical features associated with PD‐OSA were explored by comparing PD patients with and without OSA.ResultsSeventeen studies were included in the meta‐analysis. Pooled OSA prevalence was 45% of a total sample of 1448 PD patients and was associated with older age, male sex, higher body mass index (BMI), more severe motor disturbances and periodic limb movements, reduced risk of rapid eye movement sleep behavior disorder, intake of dopamine agonists, and worse excessive daytime sleepiness. No relationship emerged with cognitive functioning and neuropsychiatric manifestations.ConclusionsOSA affects nearly half of PD patients as a secondary outcome of predisposing factors such as older age and higher BMI in addition to PD‐related motor impairment. Future studies should focus on determining the impact of both clinical features and dopaminergic medication on the development of PD‐OSA.

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“…It has been hypothesized a relationship between anosognosia in neurodegenerative disease and apathy since altered emotional reactivity related to task performance may impact motivation, that in turn affects the degree of active monitoring during task performance [ 1 ]; thus, apathy in PD patients may also affect the awareness of their own condition due to shared neuropsychological (reduced self-monitoring) and neuropathophysiological (altered functioning of PFC) mechanisms [ 1 , 9 ]. Moreover, apathy in PD has been linked to worse cognition, especially executive functioning [ 11 , 12 ], which is crucial for the comprehension of one’s own (self-reflectivity) and others’ mental states (other-reflectivity) [ 15 , 16 , 17 ]. Nevertheless, studies on awareness of neuropsychiatric symptoms in PD have yielded mixed results.…”

Section: Introductionmentioning

confidence: 99%

Unawareness of Apathy in Parkinson’s Disease: The Role of Executive Dysfunction on Symptom Recognition

et al. 2023

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Altered self-awareness or anosognosia may impact patients’ everyday life by interfering with their safe and independent functioning. Symptom awareness has been linked to executive dysfunctions caused by damage to frontal regions. Apathy is a frequent neuropsychiatric manifestation of Parkinson’s disease (PD) and is considered a consequence of altered functioning of cortico-subcortical circuitries connecting the prefrontal cortex (PFC) with the basal ganglia. Thus, apathetic PD patients may be not be fully aware of their condition due to shared neuropathophysiological mechanisms. The present study aimed to explore the awareness of apathy in PD patients by comparing the self-reported evaluations with their caregivers’ ratings. Moreover, we explored the clinical predictors of possible discrepancies and their consequences on patients’ self-reported evaluation of quality of life (QoL). We found a fair agreement between patients’ self-reports and caregivers’ ratings on apathy scores, with patients reporting less severe apathetic symptoms, especially those related to executive and auto-activation processing, compared to their caregivers’ reports. Executive functioning was found to mediate the relationship between disease stage and awareness of the apathetic state. Awareness of executive apathy impacted patients’ self-reported QoL. Therefore, PD patients might be unaware of their apathetic symptoms, especially those with worse executive functioning, which plays a key role in metacognitive processes such as self-monitoring and error detection. Anosognosia for apathy in PD patients may affect their QoL perception and leads to misleading self-report evaluations that delay diagnosis and treatment.

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Neuropsychological, neuropsychiatric, and clinical correlates of affective and cognitive theory of mind in Parkinson’s disease: A meta-analysis.

Cited by 20 publications

References 114 publications

Functional alterations in resting‐state networks for Theory of Mind in Parkinson's disease

Functional alterations in resting‐state networks for Theory of Mind in Parkinson's disease

Prevalence and clinical aspects of obstructive sleep apnea in Parkinson disease: A meta‐analysis

Unawareness of Apathy in Parkinson’s Disease: The Role of Executive Dysfunction on Symptom Recognition

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