Neuropsychological performance and auditory event related potentials in schizophrenia patients and their siblings: A family study

Şevik, Ali Emre; Yağcıoğlu, A. Elif Anıl; Yağcıoğlu, Süha; Karahan, Sevilay; Gürses, Nadide; Yıldız, Mesut

doi:10.1016/j.schres.2011.04.018

Cited by 45 publications

(27 citation statements)

References 66 publications

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“…Studies of MMN in first episode schizophrenia are mixed, with some finding reduced frequency-deviant (22) or duration-deviant (3, 20, 35, 36) MMN, at least in a subgroup with no college education (18), but others finding normal duration- (26) or frequency-deviant (3, 26, 30, 34, 37) MMN amplitudes that subsequently decline over 2.5 months (34) to 1.5 years (38), in one case in association with left Heschel’s gyrus volume decline (38). Genetic studies are also mixed, with some showing MMN deficits in first-degree relatives of schizophrenia probands (39–41) but others showing no familial effects (26, 42–44) or weak genetic effects based on patient twin data (44, 45). In addition, reduced MMN has recently been observed in CHR patients (3–7), indicating that MMN is compromised prior to psychosis onset.…”

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confidence: 99%

Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity

Perez

Woods

Roach

et al. 2014

Biological Psychiatry

216

210

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Introduction Only about one third of patients at high risk for psychosis based on current clinical criteria convert to a psychotic disorder within a 2.5-year follow-up period. Targeting clinical high-risk (CHR) individuals for preventive interventions could expose many to unnecessary treatments, underscoring the need to enhance predictive accuracy with non-clinical measures. Candidate measures include event-related potential (ERP) components with established sensitivity to schizophrenia. Here we examined the mismatch negativity (MMN) component of the ERP elicited automatically by auditory deviance in CHR and early illness schizophrenia (ESZ) patients. We also examined whether MMN predicted subsequent conversion to psychosis in CHR patients. Method MMN to auditory deviants (duration, frequency, and duration+frequency “double deviant”) were assessed in 44 healthy controls (HC), 19 ESZ, and 38 CHR patients. Within CHR patients, 15 converters to psychosis were compared to 16 non-converters with at least 12 months of clinical follow-up. Hierarchical Cox regression examined the ability of MMN to predict time to psychosis onset in CHR patients. Results Irrespective of deviant type, MMN was significantly reduced in ESZ and CHR patients relative to HC, and in CHR converters relative to non-converters. MMN did not significantly differentiate ESZ and CHR patients. The duration+frequency double deviant MMN, but not the single deviant MMNs, significantly predicted the time to psychosis onset in CHR patients. Conclusions Neurophysiological mechanisms underlying automatic processing of auditory deviance, as reflected by the duration+frequency double deviant MMN, are compromised prior to psychosis onset, and can enhance the prediction of psychosis risk among CHR patients.

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confidence: 99%

Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity

Perez

Woods

Roach

et al. 2014

Biological Psychiatry

216

210

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“…fokozatos csökkenését a betegség lefolyása során több tanulmány is alátámasztja 5,7,12 . Ennek megfelelően a csökkent amplitúdójú hosszdeviáns EN pszichotikus tüneteket már megélt betegeknél a betegség kezdeti fázisában is jelen van 13 , illetve pszichésen egészséges rokonaiknál is megfigyelhető 14 .…”

Section: N100 Habituációunclassified

“…A legtöbb vizsgálat szerint a P3b amplitúdó csökkenése SZ-ben annyira stabil jellemző, hogy endofenotípus is lehet. A tünetek súlyossága sem befolyásolja az eltérés mértékét 17 , amit az is alátámaszt, hogy a betegség kezdetén, serdülőknél és rokonaiknál is eltérés mutatható ki 14 . Az eredmények azonban még nem egyértelműek a SZ, P3b és P3a kapcsolatát illetően, ill. még a P3b jellegzetességeit illetően is vannak ellentmondásos adatok 18 .…”

Section: P300unclassified

Event-Related Potentials and Clinical Symptoms in Schizophrenia

Domján¹,

Csifcsák²,

Janka³

2016

Ideggyogy Sz

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“…Furthermore, MMN has been proved useful in clinical investigations of schizophrenia patients due to its robustness to changes in attention and performance (Garrido et al, 2009). Intrestingly, also siblings of schizophrenia patients have been reported to exhibit impaired working memory reflected in a reduction of the MMN amplitude (Sevik et al, 2011). Although the literature contains conflicting results, MMN may serve as an index of genetic predisposition to schizophrenia and disease progression (Jessen et al, 2001, Michie et al, 2002, Shinozaki et al, 2002.…”

Section: Frequency Range Primary Generators Functionmentioning

confidence: 99%