Neurosarcoidosis and Transverse Myelitis: Life-Threatening Manifestations of Sarcoidosis

Abstract

Sarcoidosis, a systemic granulomatous disorder, typically involves the lungs, skin, and lymph nodes. Neurological manifestations are diverse and may include longitudinally extensive transverse myelitis (LETM), an uncommon inflammatory disorder of the spinal cord. We present a case of a 62-year-old female with LETM as the initial manifestation of sarcoidosis. The patient exhibited progressive bilateral lower extremity weakness, urinary retention, and sensory disturbances. Diagnostic workup revealed characteristic findings on spinal magnetic resonance imaging (MRI), cerebrospinal fluid analysis, and thoracic biopsy. Treatment with high-dose corticosteroids and subsequent immunomodulatory therapy resulted in significant improvement. Our case highlights the importance of including sarcoidosis in the differentials of LETM, particularly in patients with no respiratory manifestations.

Longitudinally extensive transverse myelitis as an initial manifestation of sarcoidosis: A rare case and its management

“…Her imaging findings and biopsy results were consistent with sarcoidosis‐induced transverse myelitis, and her condition improved gradually after commencing high‐dose steroids. 11 We have tabulated the reported cases of sarcoidosis‐induced LETM in the last 10 years (Table 1 ). 6 , 11 , 12 , 13 , 14 , 15 …”

“… 11 We have tabulated the reported cases of sarcoidosis‐induced LETM in the last 10 years (Table 1 ). 6 , 11 , 12 , 13 , 14 , 15 …”