This editorial examines neuroscience and its impact on the field of education. Starting with a narrative between two young children, the author intertwines research with basic principles of learning, using the interaction between two 4-year-olds to illustrate the precepts. The four principles are: (1) the brain is uniquely organized;(2) the brain is continually growing; (3) a ''brain-compatible'' classroom enables connection of learning to positive emotions; and (4) children's brains need to be immersed in real-life, hands-on, and meaningful learning experiences. The editorial concludes with an illustration of how the brain works while two children are playing at the small animal center in their classroom.