Neurosecretion

Sachs, Hans

doi:10.1002/9780470122778.ch8

Cited by 20 publications

(1 citation statement)

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“…vasopressin, oxytocin and neurophysins) have also been extensively studied in mammals. Sachs (1969Sachs ( , 1970Sachs ( , 1971) and co-workers . Using the same approach, these authors have also presented evidence that neurophysin is very likely synthesized via a precursor and that the "maturation" of this precursor is insensitive to puromycin (Sachs et al , 1971, thus leading them to hypothesize that vasopressin and neurophysin are derived from a common precursor, which is synthesized by a ribosomal mechanism .…”

Section: IImentioning

confidence: 99%

Biosynthesis and axoplasmic transport of neurophysin in the hypothalamo-neurohypophysial system of the grass frog Rana pipiens

Chang

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Section: IImentioning

confidence: 99%

Biosynthesis and axoplasmic transport of neurophysin in the hypothalamo-neurohypophysial system of the grass frog Rana pipiens

Chang

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Immunohistochemical demonstration of a CRF-associated neurophysin in the external zone of the rat median eminence

1974

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Immunocytochemical study of the hypothalamo-neurohypophysial system

Watkins

Choy

1977

Cell Tissue Res.

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Synthetic oxytocin and [8-arginine]-vasopressin conjugated to bovine thyroglobulin were used to induce specific antibodies in rabbits. The specificity of the anti-oxytocin serum, and the suitability of the anti-[8-arginine]-vasopressin serum for the detection of [8-lysine]-vasopressin, was evaluated by immunofluorescent studies of the respective hormones bound to Sepharose 4B particles. Oxytocin and [8-lysine]-vasopressin were specifically localized in the paraventricular (PVN) and supraoptic (SON) nuclei of the pig hypothalamus using the immunoperoxidase staining technique. After an examination of serial transverse and sagittal sections stained for either of the hormones we observed that: 1. In the rostral SON, oxytocin and vasopressin containing neurons were uniformly distributed; 2. In the caudal SON, most of the neurons contained oxytocin, but there were still a few 'vasopressin' neurons; 3. In the rostral PVN, the two hormones were evenly spread in neurons close to the third ventricle; 4. In the caudal PVN, the oxytocin and vasopressin containing neurons were differentially distributed, with 'oxytocin' neurons adjacent to the third ventricle, and 'vasopressin' neurons lateral to these and concentrated in the dorso-caudal PVN. In the cells of the PVN, there was evidence that the distribution of oxytocin and vasopressin is similar to the distribution of porcine neurophysin-II and porcine neurophysin-I respectively. This similarity is consistent with the one hormone--one neurophysin concept in the pig.

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Neurosecretion

Cited by 20 publications

References 100 publications

Biosynthesis and axoplasmic transport of neurophysin in the hypothalamo-neurohypophysial system of the grass frog Rana pipiens

Biosynthesis and axoplasmic transport of neurophysin in the hypothalamo-neurohypophysial system of the grass frog Rana pipiens

Immunohistochemical demonstration of a CRF-associated neurophysin in the external zone of the rat median eminence

Immunocytochemical study of the hypothalamo-neurohypophysial system

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