“…In the nervous system, neurotransmission, receptor function, and the strength of synaptic transmission is modified by pregnenolone sulfate stimulation (Baulieu, 1998). Intracerebral infusion of pregnenolone sulfate was shown to influence cognitive processes, neuronal survival, and neurogenesis (Mayo et al, 2001;Charalampopoulos et al, 2008). In pancreatic  cells and insulinoma cells, pregnenolone sulfate triggers a rapid Ca 2ϩ influx into the cells, leading to enhanced insulin secretion (Wagner et al, 2008).…”