Neurosurgery in Parkinson disease

Schüpbach, Michaël; Gargiulo, Marcela; Welter, Michael; Mallet, Luc; Béhar, C.; Houeto, Jean Luc; Maltête, David; Mesnage, Valérie; Agid, Yves

doi:10.1212/01.wnl.0000234880.51322.16

Cited by 439 publications

(415 citation statements)

References 28 publications

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“…In two randomized trials comparing bilateral STN DBS with best medical therapy at 6-month follow-up, results correspond to an improvement of 17% and 25% in both DBS series, with almost no change in the medication groups (23,24). In other studies improvement of up to 68% has been reported in PDQ-39 at up to 24 months of follow up (13,21,11,20). Interestingly, an improvement in QoL in pallidal and subthalamic DBS after 2 years in a randomized trial was only moderate and reached 11.2% and 8.9% respectively (7).…”

Section: Disclosurementioning

confidence: 81%

Quality of life and depressive symptoms in parkinson's disease after subthalamic deep brain stimulation. a 2-year follow-up study

Tykocki¹,

Szalecki²,

Koziara³

et al. 2012

Turkish Neurosurgery

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AIm:To assess the correlation between quality of life (QoL), depressive symptoms and motor signs in patients with Parkinson disease after subthalamic deep brain stimulation (DBS STN). mAterIAl and methOds: 74 patients, average age 55.6 ± 7 and duration of disease 12.3 years± 3.8, treated with l STN DBS for PD were included in the study. All patients were evaluated with (UPDRS III), (PDQ-39) (BDI) at baseline and at 6, 12, and 24-month follow up. All patients were also stratified into three groups depending on UPDRS III improvement (<30%, 30-60%, >60%). BulGulAr: Tüm ölçeklerdeki puanlar başlangıca göre önemli ölçüde azaldı. PDQ-39'daki iyileşme 6 ayda %43,3 BDI'da %25,3 ; UPDRS-III %55,5 bulundu. 24 ayda motor sonuçlar QoL sırasıyla %15,6 ve %19,6 bozuldu. BDI değişmeden kaldı. PDQ-39 için başlangıçtaki ortalama skorlar grup I'da 67,4 ± 29,7; II 64,8±32,0; III 53,4±22,0 ve BDI için, grup I'de 17,4±12,04; II 14,0±9,7; III-15,1±10,55. Puanlar 6 aylık takipte DBS'de önemli ölçüde azaldı ve ortalama değişim şöyleydi: PDQ-39, grup I %42,7, II-%40,7, III %51,6; BDI grup I %23, II %28,1, III %23,3. sOnuÇ: DBS STN sonrasında PD'de depresif belirtiler, motor bulgularda azalma ve QoL'de artış yakından ilişkilidir. QoL artışı önemli ölçüde motor belirtilere bağlıdır.

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Section: Disclosurementioning

confidence: 81%

Quality of life and depressive symptoms in parkinson's disease after subthalamic deep brain stimulation. a 2-year follow-up study

Tykocki¹,

Szalecki²,

Koziara³

et al. 2012

Turkish Neurosurgery

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“…Overall, an adverse outcome may result from a combination of mental, societal and operational factors (94). Issues with cognition have also been reported, most notably deficiencies of language fluency (95).…”

Section: Long-term Side Effects Of Surgerymentioning

confidence: 99%

Advanced research on deep brain stimulation in treating mental disorders (Review)

et al. 2017

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“…To our knowledge, only a small number of studies in the literature have specifically addressed the phenomenology of the self through a patient's subjective experience with DBS (de Haan et al 2015;de Haan et al 2013, Hariz et al 2011, Sch€ upbach et al 2006. A small number of case reports provide further insight into some of these postoperative changes to the self.…”

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confidence: 99%