Neurotoxic Effects of Aluminium Among Foundry Workers and Alzheimer’s Disease

Polizzi, S.; Pira, Enrico; Ferrara, Mauro; Bugiani, Massimiliano; Papaleo, Andrea; Albera, Roberto; Palmi, S

doi:10.1016/s0161-813x(02)00097-9

Cited by 278 publications

(144 citation statements)

References 64 publications

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“…The development of a disease due to accumulation of Al in any organ of the body requires a continuous process lasting for many years. It has been known since 1960s that chronic Al exposure causes neuropsychological damage, encephalopathy and connected attacks, incoordination, intentional tremor, and cognitive deficits (Molloy et al 2007;Polizzi et al 2002). This suggests that chronic Al exposure via drinking water might constitute a significant risk factor for mild cognitive impairment (MCI), dementia, and other neurological diseases, which are not considered a serious medical or psychiatric situation in the elderly, due to having mild memory and cognitive impairments but no dementia (Flaten 2001;Petersen et al 1999).…”

Section: Discussionmentioning

confidence: 99%

“…In their observational study carried out between 1988 and 2003, Rondeau et al (2009) demonstrated that cognitive disorders and dementia are detected in higher rates in the people living in regions with drinking water containing high levels of Al. Moreover, in another study published in 1995, it was reported that there could be a direct relationship between the amount of Al existing in the drinking water and dementia (Nieboer et al 1995;Polizzi et al 2002). However, it is not easy to define this relationship clearly, because diseases like dementia and AD have multifactorial etiologies and often there is multiple complexity factors involved in this kind of study (Nieboer et al 1995).…”

Section: Discussionmentioning

confidence: 99%

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Effect of High Aluminum Concentration in Water Resources on Human Health, Case Study: Biga Peninsula, Northwest Part of Turkey

Bakar

Karaman

Baba

et al. 2009

Arch Environ Contam Toxicol

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Widespread and intense zones of silicified, propylitic, and argillic alteration exist as outcrop around the Biga Peninsula, NW Turkey. Most of the springs in the study area surface out from these altered volcanic rocks. The concentrations of aluminum (Al) in these springs ranged from 13.17 to 15.70 ppm in this region. These high levels of Al were found to exceed the maximum allowable limits (0.2 ppm) depicted in national and international standards of drinking water quality. Therefore, the effect of high Al in water resources on human health was evaluated in this research. A total of 273 people aged above 18 years and living in the Kirazli region (whose water supply is from springs emerging from these alteration zones) and in the Ciplak-Halileli region (whose water supply is provided from an alluvium aquifer) were selected as the research group. For this group, a questionnaire was completed that contained questions on descriptive characteristics of humans and a Mini-Mental State Examination (MMSE) was administered by the authors using the face-to-face interview technique. A neurological examination was then performed by the neurology specialist as a second-stage investigation. Finally, 10 ml of venous blood samples were obtained from these people as a third-stage analysis to determine the serum Al levels together with vitamin B 12 , folic acid, and thyroidstimulating hormone parameters. The result typically revealed that the MMSE score was less in 31.9% and there was no statistically significant difference between the two regions. However, the result also showed that neuropathy in the history (including a careful past medical history) was significantly higher in the Kirazli region.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of High Aluminum Concentration in Water Resources on Human Health, Case Study: Biga Peninsula, Northwest Part of Turkey

Bakar

Karaman

Baba

et al. 2009

Arch Environ Contam Toxicol

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“…Furthermore, the levels measured in Kirazlı spring are two orders of magnitude greater than the standard value of 200 lg/L. Although oral consumption of high aluminum content waters have been reported to cause Alzheimer's disease (Nieboer et al 1995;Nordberg 1998;Polizzi et al 2002), detailed medical studies are to be conducted on the local inhabitants of Kirazlı before conclusive remarks are made regarding the health impacts of water quality in the Kirazlı area. In addition to aluminum, iron, lead, manganese, nickel, and zinc concentrations are much higher in Kirazlı waters (mean values 852.25, 30.45, 401.47, 7.48, and 82.43 lg/L, respectively) than their corresponding levels in Balaban waters (mean values 18.75, 0.98, 9.22, 0.65, and 5.90 lg/L, respectively; Fig.…”

Section: Hydrogeochemistrymentioning

confidence: 95%

Effect of Alteration Zones on Water Quality: A Case Study from Biga Peninsula, Turkey

Baba

Gündüz

2009

Arch Environ Contam Toxicol

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Widespread and intense zones of silicified, propylitic, and argillic alteration can be found in the Ç an volcanics of Biga Peninsula, northwest Turkey. Most of the springs in the study area surface out from the boundary between fractured aquifer (silicified zone) and impervious boundary (argillic zone). This study focuses on two such springs in Kirazlı area (Kirazlı and Balaban springs) with a distinct quality pattern. Accordingly, field parameters (temperature, pH, and electrical conductivity), major anion and cation (sodium, potassium, calcium, magnesium, chloride, bicarbonate, and sulfate), heavy metals (aluminum, arsenic, barium, chromium, cobalt, cupper, iron, lithium, manganese, nickel, lead, and zinc), and isotopes (oxygen-18, deuterium, and tritium) were determined in water samples taken from these springs during 2005 through 2007. The chemical analyses showed that aluminum concentrations were found to be two orders of magnitude greater in Kirazlı waters (mean value 13813.25 lg/L). The levels of this element exceeded the maximum allowable limits given in national and international standards for drinking-water quality. In addition, Balaban and Kirazlı springs are [55 years old according to their tritium levels; Kirazlı spring is older than Balaban spring. Kirazlı spring is also more enriched than Balaban spring based in oxygen-18 and deuterium values. Furthermore, Kirazlı spring water has been in contact with altered rocks longer than Balaban spring water, according to its relatively high chloride and electrical conductivity values.Water-rock interaction is an important topic influencing the water quality as well as human health. Particularly in altered systems, these interactions are more important for local inhabitants using water for drinking purposes because the water in such systems might contain increased levels of certain elements that are potentially detrimental to human health. Thus, these interactions should be assessed carefully in areas of complex geology where rocks formed as a result of hydrothermal system are predominant.Hydrothermal fluids carry metals in solution, coming either from a nearby igneous source, from leaching of subsurface rocks, or both (Henley et al. 1984). These fluids then alter other rocks, changing their mineralogy and chemical composition (Nicholson 1993;Verma et al. 2005;Pandarinath et al. 2008). Complex zoned alteration patterns have been well documented from a large number of important hydrothermal ore deposit types, including submarine-volcanogenic massive sulphide (Finlow-Bates and

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“…Al +3 sinir sistemine transferrinin reseptör aracılıklı endositozunu kullanarak kan beyin bariyerini geçer. 8,9 Bu da Al zehirlenmelerinde bireysel duyarlılıktaki farklı-lığı açıklayabilir. 9 Vücutta oluşan Al-transferrin kompleksinin yaklaşık %0,005'i beyine geçer.…”

unclassified

“…8,9 Bu da Al zehirlenmelerinde bireysel duyarlılıktaki farklı-lığı açıklayabilir. 9 Vücutta oluşan Al-transferrin kompleksinin yaklaşık %0,005'i beyine geçer. 8 Al bileşikleri gastrointestinal sistemde diğer elementlerin de absorbsiyonunu değiştirebilir.…”

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Aluminum Toxicity and its Role in Neurodegenerative Diseases: Review

Sipahi¹,

Palabıyık²,

Balci³

et al. 2015

Turkiye Klinikleri J Neur

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6Alüminyum Toksisitesi ve Nörodejeneratif Hastalıklardaki Rolü Ö ÖZ ZE ET T Günlük yaşamımızda çok yaygın kullanılan alüminyum (Al), oksijen ve silikondan sonra yeryüzünde en fazla bulunan üçüncü elementtir. Endüstride paketleme, inşaat, elektrik aletleri ve içecek kutuları gibi birçok farklı ürünün yapımında kullanılan Al bileşikleri gıda katkı maddesi olarak da kullanılmaktadır. Türkiye'de de Gıda, Tarım ve Hayvancılık Bakanlığı tarafından "Türk Gıda Kodeksi Gıda Katkı Maddeleri Yönetmeliği" ekinde gıda katkı maddesi olarak kullanımına izin verilen miktarlar belirtilmiştir. Al gıdalara özellikle ilave edildiği durumlar dışında, kontaminasyon olarak da bulunmaktadır. Ayrıca gıdaların paketlenmesinde Al folyo kullanılması, gıdaların yüksek ısıda Al folyoda pişirilmesi de gıdaların Al içeriğini arttırmaktadır. Ancak gıda zincirindeki Al miktarı, antiasitler ve analjezikler gibi ilaçlarda kullanılan miktarıyla kıyaslandığında oldukça azdır. Al toksisitesi çoğunlukla kronik renal hasarı olan hastalarda veya iş yerinde Al'a maruz kalanlarda gö-rülmektedir. Akciğer, kemik ve santral sinir sistemi ana hedef organlardır. Alzheimer hastalığı, Parkinson hastalığı, Huntington hastalığı, Amyotrofik lateral skleroz, spinal muskuler atrofi gibi dünyada milyonlarca insanı etkileyen ve henüz kesin bir çözüm bulunamayan nörodejeneratif hastalıklarda beyin nöronlarının oksidatif strese oldukça duyarlı olduğu ve bunun Al toksisitesiyle indüklenebi-leceği düşünülmektedir. Deney hayvanlarında yapılan çalışmalar Al'un nörotoksik olduğunu, kanbeyin bariyerinin geçirgenliğini arttırdığını ve beyinde pek çok önemli enzimi inhibe ettiğini göstermiştir. Demansın belirgin olarak gözlenmediği diyaliz hastalarında da kan Al konsantrasyonları oldukça yüksek bulunmuştur. Ayrıca Al başta olmak üzere bazı toksik metaller düzeylerinde otistik çocuklarda sağlıklı çocuklara göre artış gözlenmiştir. Bu derlemenin amacı, yaygın kullanım alanına sahip Al'un nörodejeneratif hastalıklardaki rolünü değerlendirmektir.

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Neurotoxic Effects of Aluminium Among Foundry Workers and Alzheimer’s Disease

Cited by 278 publications

References 64 publications

Effect of High Aluminum Concentration in Water Resources on Human Health, Case Study: Biga Peninsula, Northwest Part of Turkey

Effect of High Aluminum Concentration in Water Resources on Human Health, Case Study: Biga Peninsula, Northwest Part of Turkey

Effect of Alteration Zones on Water Quality: A Case Study from Biga Peninsula, Turkey

Aluminum Toxicity and its Role in Neurodegenerative Diseases: Review

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