Neurotoxic effects of high-dose piperine on hippocampal synaptic transmission and synaptic plasticity in a rat model of memory impairment

Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement

“…For example, as there is no generally accepted effective treatment for SCI, we did not employ a positive control in the experiments. Besides, a previous study has indicated high doses (20 mg/kg) of Piperine have neurotoxic effects (Nazifi et al, 2020) and long-term administration of Piperine (10 mg/kg daily for 60 days) was found to impair spermatogenesis in male albino rats (Chinta, Coumar, & Periyasamy, 2017). Moreover, studies have observed that the individual use of Piperine and other drugs can increase the drug bioavailability which may carry the risk of unintended adverse effects (Ziegenhagen, Heimberg, Lampen, & Hirsch-Ernst, 2021).…”

“…Piperine, an alkaloid isolated from black pepper, has long been recognized for its pharmacological and medicinal value, including its antiinflammatory, antioxidant, antipyroptotic, and anticoagulant activities (Guo et al, 2021; Haq et al, 2021). A previous study showed that long‐term administration of a relatively low dose of Piperine (2.5–10 mg/kg) improved memory in memory‐impaired model rats with no neurotoxic side effects (Nazifi, Ashrafpoor, Oryan, Esfahani, & Moghadamnia, 2020). Moreover, a recent report showed that Piperine promotes autophagic flux by activating P2RX4 activation in a model of Parkinson's disease (Li, Lu, et al, 2022).…”