Neurotoxic responses in brain of catla catla exposed to cypermethrin: A semiquantitative multibiomarker evaluation

Jindal, Ravul; Sharma, Ritu

doi:10.1016/j.ecolind.2019.105485

Cited by 24 publications

(12 citation statements)

References 38 publications

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“…The expression of caspase 3 was recently shown to increase in the brains of juvenile Chinook salmon treated with 1.50 μg/L bifenthrin for 96 h . Similarly, caspase 3 expression increased in the brains of common carp (Cyprinus carpio) treated with 5 μg/L cypermethrin, which subsequently induced necrosis in the neuronal cells of common carp, and in the brains of South Asian carp (Catla catla) treated with 0.124 μg/L cypermethrin . This study, however, is the first known study to report metabolomic profile changes in the brains of steelhead trout exposed to bifenthrin that coincide with previously reported morphological effects involved in apoptosis and inflammation.…”

Section: Discussionmentioning

confidence: 73%

Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment

Magnuson

Cryder

Andrzejczyk

et al. 2020

Environ. Sci. Technol.

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The pyrethroid insecticide, bifenthrin, is frequently measured at concentrations exceeding those that induce acute and chronic toxicity to several invertebrate and fish species residing in the Sacramento-San Joaquin Delta of California. Since the brain is considered to be a significant target for bifenthrin toxicity, juvenile steelhead trout (Oncorhynchus mykiss) were treated with concentrations of bifenthrin found prior to (60 ng/L) and following (120 ng/L) major stormwater runoff events with nontargeted metabolomics used to target transcriptomic alterations in steelhead brains following exposure. Predicted responses were involved in cellular apoptosis and necrosis in steelhead treated with 60 ng/L bifenthrin using the software Ingenuity Pathway Analysis. These responses were predominately driven by decreased levels of acetyl-L-carnitine (ALC), docosahexaenoic acid (DHA), and adenine. Steelhead treated with 120 ng/L bifenthrin had reductions of lysophosphatidylcholines (LPC), lysophosphatidylethanolamines (LPE), and increased levels of betaine, which were predicted to induce an inflammatory response. Several genes predicted to be involved in apoptotic (caspase3 and nrf 2) and inflammatory (miox) pathways had altered expression following exposure to bifenthrin. There was a significantly increased expression of caspase3 and miox in fish treated with 120 ng/L bifenthrin with a significant reduction of nrf 2 in fish treated with 60 ng/L bifenthrin. These data indicate that bifenthrin may have multiple targets within the brain that affect general neuron viability, function, and signaling potentially through alterations in signaling fatty acids.

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Section: Discussionmentioning

confidence: 73%

Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment

Magnuson

Cryder

Andrzejczyk

et al. 2020

Environ. Sci. Technol.

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“…The 96-h LC 50 of CYP in C. catla was determined by semi-static acute toxicity test (APHA, 2012) by using Probit method (Finney, 1980) and was found to be 1.24 μg/L (Jindal & Sharma, 2019). Based on the acute toxicity, one-third (0.41 μg/L) and one tenth (0.12 μg/L) of 96 h LC 50 of CYP was selected as the sublethal concentrations for the assessment of genotoxicity.…”

Section: Experimental Designmentioning

confidence: 99%

In vivo genotoxic effects of commercial grade cypermethrin on fish peripheral erythrocytes

Sharma

Jindal

2022

Environ and Mol Mutagen

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The study explicates the genotoxic effects of commercial grade cypermethrin on peripheral erythrocytes of Catla catla, chronically exposed to two environmentally relevant concentrations. The fish was treated with sub-lethal concentrations 0.12 μg/L and 0.41 μg/L (1/10th and /1/3rd of 96 h LC 50 ) of cypermethrin for 45 days. DNA damage in the exposed fish was assessed using alkaline comet assay, presence of micronuclei (MN), erythrocyte nuclear and cytoplasmic abnormalities.Exposure to cypermethrin induced a dose-dependent increase in percent DNA damage, micronucleus frequency and erythrocyte abnormalities. Nuclear anomalies such as notched nuclei, lobed nuclei, bridged nuclei, and deformed nuclei; and cytoplasmic anomalies like anisochromasia, vacuolated cytoplasm, lobed cells, and echinocytes were observed. The findings revealed the genotoxic potential of commercial formulations pyrethroid cypermethrin at concentrations found in the environment and their potential deleterious effects on nontarget aquatic organisms.

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“…Pesticides modified the actions of AChE in C. carpio, L. rohita, O. mossambicus, Rhamdia quelen, and Colisa fasciatus [53][54][55]. Furthermore, CYP-induced neurotoxicity and apoptotic changes in the brain of C. catla [35].…”

Section: Neurotoxicitymentioning

confidence: 99%

“…It was found that CYP exposure induced haemato-biochemical alterations in several fish species such as Nile tilapia [121], common carp [122], Brycon amazonicus [123], Anabas testudineus [124], rohu [125], Heteropneustes fossilis [120], Prochilodus lineatus [126], and C. batrachus [127]. Moreover, CYP induced behavioral changes in Nile tilapia [128], developmental toxicity of zebrafish [129], immunotoxicity of common carp [32], neurotoxicity of Catla [35], genotoxicity [29,30,33,130], and oxidative stress damage [131,132]. Furthermore, CYP induced serious histopathological alterations of African catfish [133], Nile tilapia [134], common carp [33], and Catla [34].…”

Section: Cypermethrin (Cyp) [(Rs)-cyano-(3-phenoxyphenyl) Methyl-(irs)-cis -Transmentioning

confidence: 99%

“…Studies showed that CYP induced genotoxicity and oxidative stress in the exposed zebrafish (Danio rerio) [29,30], malformations in rohu (Labeo rohita) during the early developmental stages [31], immunotoxic effects in common carp (Cyprinus carpio) [32], DNA damage, apoptosis, and histopathological alterations in C. carpio [33], hepatotoxicity in the Catla (Catla catla) [34], and neurotoxicity and apoptotic changes in the brain of C. catla [35].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Overview on the Potential Hazards of Pyrethroid Insecticides in Fish, with Special Emphasis on Cypermethrin Toxicity

Farag

Alagawany

Bilal

et al. 2021

Animals

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Pesticides are chemicals used to control pests, such as aquatic weeds, insects, aquatic snails, and plant diseases. They are extensively used in forestry, agriculture, veterinary practices, and of great public health importance. Pesticides can be categorized according to their use into three major types (namely insecticides, herbicides, and fungicides). Water contamination by pesticides is known to induce harmful impacts on the production, reproduction, and survivability of living aquatic organisms, such as algae, aquatic plants, and fish (shellfish and finfish species). The literature and information present in this review article facilitate evaluating the toxic effects from exposure to various fish species to different concentrations of pesticides. Moreover, a brief overview of sources, classification, mechanisms of action, and toxicity signs of pyrethroid insecticides in several fish species will be illustrated with special emphasis on Cypermethrin toxicity.

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Neurotoxic responses in brain of catla catla exposed to cypermethrin: A semiquantitative multibiomarker evaluation

Cited by 24 publications

References 38 publications

Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment

Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment

In vivo genotoxic effects of commercial grade cypermethrin on fish peripheral erythrocytes

An Overview on the Potential Hazards of Pyrethroid Insecticides in Fish, with Special Emphasis on Cypermethrin Toxicity

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