2022
DOI: 10.1016/j.envpol.2022.118856
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Neurotoxicity induced by toluene: In silico and in vivo evidences of mitochondrial dysfunction and dopaminergic neurodegeneration

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Cited by 21 publications
(7 citation statements)
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“…Specifically in industrial settings, the leakage and emission of toluene bring air pollution and hazard to human health [6]. Employees exposed to toluene gas for prolonged periods of time have been reported to suffer from neurological damage with symptoms such as headaches and drowsiness [7][8][9]. Short-term inhalation of high concentrations of toluene vapor can cause nausea, decreased vision, muscle cramps, dizziness, and even engenders permanent brain toxicity and death in severe cases [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…Specifically in industrial settings, the leakage and emission of toluene bring air pollution and hazard to human health [6]. Employees exposed to toluene gas for prolonged periods of time have been reported to suffer from neurological damage with symptoms such as headaches and drowsiness [7][8][9]. Short-term inhalation of high concentrations of toluene vapor can cause nausea, decreased vision, muscle cramps, dizziness, and even engenders permanent brain toxicity and death in severe cases [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…Because of all these characteristics and its sensitivity to toxicants, C. elegans has established itself as an important model organism for research in toxicology (Leung et al, 2008). For instance, the toxicity assessment of pesticides, toluene also used C. elegans as a model organism (Behl et al, 2016; Meyer & Williams, 2014; Moya et al, 2022; Soares et al, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…For instance, the toxicity assessment of pesticides, toluene also used C. elegans as a model organism (Behl et al, 2016;Meyer & Williams, 2014;Moya et al, 2022;Soares et al, 2022).…”
mentioning
confidence: 99%
“…For example, when humans are exposed to toluene at a concentration higher than the threshold, it may cause damage to the skin, kidneys, liver and central nervous system. 1 Moreover, the stimulation threshold of toluene for the eyes and nose is 250 mg m À3 (53.07 ppm), while that for dizziness is 1.25 mg m À3 (265.37 ppm). 2 Thus, it is urgent and necessary to monitor toluene during industrial processes.…”
Section: Introductionmentioning
confidence: 99%