Neurotoxicity mediated by oxidative stress caused by titanium dioxide nanoparticles in human neuroblastoma (SH-SY5Y) cells

Ferraro, Sebastián Ariel; Domingo, Mariela Gisele; Etcheverrito, Analía; Olmedo, Daniel Gustavo; Tasat, Deborah Ruth

doi:10.1016/j.jtemb.2019.126413

Cited by 45 publications

(14 citation statements)

References 60 publications

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“…Exposure to > 10 mg L −1 of nano-TiO 2 for 72 h suppressed viability and induced autophagy and apoptosis of human neuroblastoma cell line due to the elevated oxidative stress. [42,43] Cytotoxicity and induction of apoptosis have also been found in the human microglia N9 cells exposed to nano-TiO 2 . [44] The uptake and Figure 1.…”

Section: Neural Systemmentioning

confidence: 97%

Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Luo

Xie

et al. 2020

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Titanium dioxide nanoparticles (nano‐TiO2) are widely used in consumer products, raising environmental and health concerns. An overview of the toxic effects of nano‐TiO2 on human and environmental health is provided. A meta‐analysis is conducted to analyze the toxicity of nano‐TiO2 to the liver, circulatory system, and DNA in humans. To assess the environmental impacts of nano‐TiO2, aquatic environments that receive high nano‐TiO2 inputs are focused on, and the toxicity of nano‐TiO2 to aquatic organisms is discussed with regard to the present and predicted environmental concentrations. Genotoxicity, damage to membranes, inflammation and oxidative stress emerge as the main mechanisms of nano‐TiO2 toxicity. Furthermore, nano‐TiO2 can bind with free radicals and signal molecules, and interfere with the biochemical reactions on plasmalemma. At the higher organizational level, nano‐TiO2 toxicity is manifested as the negative effects on fitness‐related organismal traits including feeding, reproduction and immunity in aquatic organisms. Bibliometric analysis reveals two major research hot spots including the molecular mechanisms of toxicity of nano‐TiO2 and the combined effects of nano‐TiO2 and other environmental factors such as light and pH. The possible measures to reduce the harmful effects of nano‐TiO2 on humans and non‐target organisms has emerged as an underexplored topic requiring further investigation.

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Section: Neural Systemmentioning

confidence: 97%

Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Luo

Xie

et al. 2020

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133

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“…Although we report for the first time that Nec-1 can mitigate the neurotoxicity of TNPs by suppressing the necroptosis signaling pathway, our study has a few limitations. Firstly, the cytotoxicity of nano-sized materials differs from their bulk ones and could be largely influenced by surface properties [32], which may explain the contrary result of increased cell viability found by Sebastián et al [33]. Therefore, it is essential to comprehensively evaluate nanotoxicity on subjects from multiple aspects, such as cell proliferation, membrane integrity, oxidative stress, inflammation, mitochondrial function, cell cycle, cytoskeleton, and epigenetics.…”

Section: Discussionmentioning

confidence: 99%

Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1

Zhou

Huang

et al. 2020

Nanoscale Res Lett

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Titanium dioxide nanomaterials are applied in numerous fields due to their splendid physicochemical characteristics, which in turn poses a potential threat to human health. Recently, numerous in vivo studies have revealed that titanium dioxide nanoparticles (TNPs) can be transported into animal brains after exposure through various routes. Absorbed TNPs can accumulate in the brain and may disturb neuronal cells, leading to brain dysfunction. In vitro studies verified the neurotoxicity of TNPs. The mechanisms underlying the neurotoxicity of TNPs remains unclear. Whether necroptosis is involved in the neurotoxicity of TNPs is unknown. Therefore, we performed an in vitro study and found that TNPs induced inflammatory injury in SH-SY5Y cells in a dose-dependent way, which was mitigated by necrostatin-1 (Nec-1) pretreatment. Since receptor-interacting protein kinase 1 (RIP1) is reported to be the target of Nec-1, we silenced it by siRNA. We exposed mutant and wild-type cells to TNPs and assessed inflammatory injury. Silencing RIP1 expression inhibited inflammatory injury induced by TNPs exposure. Taken together, Nec-1 ameliorates the neurotoxicity of TNPs through RIP1. However, more studies should be performed to comprehensively assess the correlation between the neurotoxicity of TNPs and RIP1.

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“…Accumulating evidence demonstrated that the surface charge, sedimentation, and aggregation of TiO 2 NPs might cause toxicity to human beings and animals (Acar et al, 2015). In most existing studies, genotoxicity (Carriere, Arnal, & Douki, 2020), cytotoxicity (Xu et al, 2020), and neurotoxicity (Ferraro, Domingo, Etcheverrito, Olmedo, & Tasat, 2020) have been confirmed. Similarly, a large number of in vivo studies have demonstrated that, when rats and mice are exposed to TiO 2 NPs, animal organs such as liver, spleen, kidney, heart, lung, testes, and ovaries could be damaged to different degrees regarding different intervention routes, periods, dosages, sample sources, and particle sizes (An et al, 2020).…”

Section: Nano‐metal Oxidesmentioning

confidence: 96%

Research progress on the carcinogenicity of metal nanomaterials

Liu

Kong

2021

J of Applied Toxicology

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With the rapid development of nanotechnology, new nanomaterials with enormous potentials continue to emerge, especially metal nanomaterials. Metal nanomaterials possess the characteristics of metals and nanomaterials, so they are widely used in many fields. But at the same time, whether the use or release of metal nan4omaterials into the environment is toxic to human beings and animals has now attained widespread attention at home and abroad. Currently, it is an indisputable fact that cancer ranks among the top causes of death among residents worldwide. The properties of causing DNA damage and mutations possessed by these metal nanomaterials make them unpredictable influences in the body, subsequently leading to genotoxicity and carcinogenicity. Due to the increasing evidence of their roles in carcinogenicity, this article reviews the toxicological and carcinogenic effects of metal nanomaterials, including nano‐metal elements (nickel nanoparticles, silver nanoparticles, and cobalt nanoparticles) and nano‐metal oxides (titanium dioxide nanoparticles, silica nanoparticles, zinc oxide nanoparticles, and alumina nanoparticles). This article provides a reference for the researchers and policymakers to use metal nanomaterials rationally in modern industries and biomedicine.

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Neurotoxicity mediated by oxidative stress caused by titanium dioxide nanoparticles in human neuroblastoma (SH-SY5Y) cells

Cited by 45 publications

References 60 publications

Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1

Research progress on the carcinogenicity of metal nanomaterials

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Neurotoxicity mediated by oxidative stress caused by titanium dioxide nanoparticles in human neuroblastoma (SH-SY5Y) cells

Cited by 45 publications

References 60 publications

Rethinking Nano‐TiO2 Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Rethinking Nano‐TiO2 Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1

Research progress on the carcinogenicity of metal nanomaterials

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Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals

Rethinking Nano‐TiO₂ Safety: Overview of Toxic Effects in Humans and Aquatic Animals