Neurotoxicity of pesticides – A link to neurodegeneration

Vellingiri, Balachandar; Chandrasekhar, Mamatha; Sabari, S. Sri; Gopalakrishnan, Abilash Valsala; Narayanasamy, Arul; Venkatesan, Dhivya; Iyer, Mahalaxmi; Kesari, Kavindra Kumar; Dey, Abhijit

doi:10.1016/j.ecoenv.2022.113972

Cited by 57 publications

(18 citation statements)

References 123 publications

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“…Much research has been conducted on this topic and here we discuss a few examples. For a more detailed explanation of the neurotoxic effects of pesticides, epidemiological studies and neurotoxicity mechanisms, see recent reviews ( Xiao et al, 2021 ; Arab and Mostafalou, 2022 ; Vellingiri et al, 2022 ).…”

Section: Risk and Protective Factors For Neuroinflammation In Neurode...mentioning

confidence: 99%

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

Kip

Parr‐Brownlie

2023

Front. Neurosci.

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Since the mid-20th century, Western societies have considered productivity and economic outcomes are more important than focusing on people’s health and wellbeing. This focus has created lifestyles with high stress levels, associated with overconsumption of unhealthy foods and little exercise, which negatively affect people’s lives, and subsequently lead to the development of pathologies, including neurodegenerative and psychiatric disorders. Prioritizing a healthy lifestyle to maintain wellbeing may slow the onset or reduce the severity of pathologies. It is a win-win for everyone; for societies and for individuals. A balanced lifestyle is increasingly being adopted globally, with many doctors encouraging meditation and prescribing non-pharmaceutical interventions to treat depression. In psychiatric and neurodegenerative disorders, the inflammatory response system of the brain (neuroinflammation) is activated. Many risks factors are now known to be linked to neuroinflammation such as stress, pollution, and a high saturated and trans fat diet. On the other hand, many studies have linked healthy habits and anti-inflammatory products with lower levels of neuroinflammation and a reduced risk of neurodegenerative and psychiatric disorders. Sharing risk and protective factors is critical so that individuals can make informed choices that promote positive aging throughout their lifespan. Most strategies to manage neurodegenerative diseases are palliative because neurodegeneration has been progressing silently for decades before symptoms appear. Here, we focus on preventing neurodegenerative diseases by adopting an integrated “healthy” lifestyle approach. This review summarizes the role of neuroinflammation on risk and protective factors of neurodegenerative and psychiatric disorders.

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Section: Risk and Protective Factors For Neuroinflammation In Neurode...mentioning

confidence: 99%

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

Kip

Parr‐Brownlie

2023

Front. Neurosci.

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“…Pestizide wie 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP), Paraquat, Maneb, Organochlorine und Rotenon werden u. a. aufgrund epidemiologischer Untersuchungen verdächtigt, eine toxische Rolle bei der Entstehung der Parkinson-Erkrankung zu spielenmöglicherweise interagierend mit genetischen Faktoren. Die Details des kausalen Zusammenhangs sind jedoch noch nicht abschließend geklärt [17]. Als pathophysiologische Faktoren werden diskutiert: oxidativer Stress, Beeinträchtigung der Dopamintransporter und mitochondrialer Funktionen, α-Synuclein-Propagation und Neuroinflammation.…”

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Metabolische und toxische Enzephalopathien – Teil 2: Toxische Enzephalopathien

Erbguth¹

2023

Intensivmedizin up2date

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“…The cause and severity of PD may be influenced by a variety of demographic and environmental factors [ 3 , 4 ]. PD is multi-factorial, but ageing is considered to one of the prime causative agent amongst others [ 5 , 6 ]; however, the pathophysiology of PD is still elusive [ 7 ]. People living with PD are more likely to develop several other diseases, including heart disease [ 8 ], cancer [ 9 ], gastrointestinal disorders [ 10 ], type 2 diabetes mellitus (T2DM) [ 11 ], vitamin D deficiency [ 12 ], peripheral neuropathy [ 13 ], and musculoskeletal diseases [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach

et al. 2023

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Growing evidence suggest that there is a connection between Parkinson’s disease (PD) and insulin dysregulation in the brain, whilst the connection between PD and type 2 diabetes mellitus (T2DM) is still up for debate. Insulin is widely recognised to play a crucial role in neuronal survival and brain function; any changes in insulin metabolism and signalling in the central nervous system (CNS) can lead to the development of various brain disorders. There is accumulating evidence linking T2DM to PD and other neurodegenerative diseases. In fact, they have a lot in common patho-physiologically, including insulin dysregulation, oxidative stress resulting in mitochondrial dysfunction, microglial activation, and inflammation. As a result, initial research should focus on the role of insulin and its molecular mechanism in order to develop therapeutic outcomes. In this current review, we will look into the link between T2DM and PD, the function of insulin in the brain, and studies related to impact of insulin in causing T2DM and PD. Further, we have also highlighted the role of various insulin signalling pathway in both T2DM and PD. We have also suggested that T2DM-targeting pharmacological strategies as potential therapeutic approach for individuals with cognitive impairment, and we have demonstrated the effectiveness of T2DM-prescribed drugs through current PD treatment trials. In conclusion, this investigation would fill a research gap in T2DM-associated Parkinson’s disease (PD) with a potential therapy option. Graphical Abstract

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Neurotoxicity of pesticides – A link to neurodegeneration

Cited by 57 publications

References 123 publications

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders

Metabolische und toxische Enzephalopathien – Teil 2: Toxische Enzephalopathien

Type 2 Diabetes (T2DM) and Parkinson’s Disease (PD): a Mechanistic Approach

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