Neurotoxicity of sodium salicylate to the spiral ganglion neurons: GABAA receptor regulates NMDA receptor by Fyn-dependent phosphorylation

Liu, Peiqiang; Qin, Danxue; Huang, Xi; Ye, Wenhua; Lin, Xiaoyu; Su, Jiping

doi:10.1007/s00359-019-01339-z

Cited by 7 publications

(1 citation statement)

References 39 publications

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“…Sodium salicylate, a formerly used antirheumatic agent sharing the same active compound with anti-inflammatory drug aspirin, can induce the adverse reaction of acute tinnitus at high doses, [14] and thus has been widely adopted in the establishments of animal models with the purpose of studying the mechanisms of tinnitus. [11,15,16,17] Furthermore, the plasm concentration of salicylate could reach the peak value about five minutes after salicylate administration and maintain about six hours, [18] making it possible to continuously monitor the brain activation mapping before and after salicylate treatment. In this study, we measured the whole-brain microvasculature dynamics after salicylate treatment in mice using functional ultrasound (fUS) [19] for the first time, to determine the brain structure in the limbic system that was most affected by tinnitus.…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity Alterations and Molecular Characterization of the Anterior Cingulate Cortex in Tinnitus Pathology without Hearing Loss

Fan,

Guan,

Zhong

et al. 2023

Advanced Science

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Compared with individuals with hearing loss, tinnitus patients without hearing loss have more psychological or emotional problems. Tinnitus is closely associated to abnormal metabolism and function of the limbic system, a key brain region for emotion experience, but the underlying molecular mechanism remains unknown. Using whole‐brain microvasculature dynamics imaging, the anterior cingulate cortex (ACC) is identified as a key brain region of limbic system involve in the onset of salicylate‐induced tinnitus in mice. In the tinnitus group, there is enhanced purine metabolism, oxidative phosphorylation, and a distinct pattern of phosphorylation in glutamatergic synaptic pathway according to the metabolome profiles, quantitative proteomic, and phosphoproteomic data of mice ACC tissue. Electroencephalogram in tinnitus patients with normal hearing thresholds show that the functional connectivity between pregenual anterior cingulate cortex and the primary auditory cortex is significantly increased for high‐gamma frequency band, which is positively correlated with the serum glutamate level. These findings indicate that ACC plays an important role in the pathophysiology of tinnitus by interacting with the primary auditory cortex and provide potential molecular targets in the ACC for tinnitus treatment.

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