Neurotoxicology of metals and metallic nanoparticles in Caenorhabditis elegans

Agarrayua, Danielle Araújo; Silva, Aline Castro; Saraiva, Nariani Rocha; Soares, Ana Thalita Gonçalves; Aschner, Michael; Ávila, Daiana Silva

doi:10.1016/bs.ant.2023.03.001

Cited by 3 publications

(1 citation statement)

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“…The biotoxicities on C. elegans of Hg and Pb are strong, as they induce damaging effects in C. elegans , impacting antioxidative enzymes, lifespan, and reproductive toxicity ( Huang et al, 2015 ). For instance, Lead (Pb) exposure has been linked to early neurotoxic sequelae, methylmercury (MeHg) causes alterations in body length, locomotion, and neurotoxicity, and Cadmium (Cd) leads to reproductive impairments and oxidative stress, ultimately resulting in Cd-induced neurotoxicity ( Agarrayua et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Simira cordifolia protects against metal induced-toxicity in Caenorhabditis elegans

Duran-Izquierdo,

Sierra-Marquez,

Taboada-Alquerque

et al. 2023

Front. Pharmacol.

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Simira cordifolia (Hook.f.) Steyerm (Rubiaceae) is a vascular plant used in Northern Colombia as a source of pigments and wood. However, there is a lack of information regarding its pharmacology and toxicity. This research aimed to study the hydroalcoholic extract of Simira cordifolia as a protector against metal-induced toxicity in Caenorhabditis elegans. Preliminary phytochemical screening of the hydroalcoholic extract of S. cordifolia (HAE-Sc) was conducted using HPLC-ESI-QTOF. Wild-type N2 C. elegans larvae were exposed to different concentrations of HAE-Sc evaluating lethality (50–5000 μg/mL), growth, lifespan, resistance to heat stress, and its protective effect against Mercury (Hg)-, Lead (Pb)- and Cadmium (Cd)-induced lethality (50–1000 μg/mL). The main metabolites present in the extract were iridoids, β-carboline-alkaloids and polyphenols. Bioassays demonstrated that HAE-Sc exhibited low toxicity, with significant lethality (4.2% and 9.4%) occurring at 2500–5000 μg/mL. Growth inhibition reached up to 23.3%, while reproduction declined 13% and 17% at concentrations 500 and 1000 μg/mL, respectively. HAE-Sc enhanced the survival rate of the nematode under thermal stress by up to 79.8%, and extended the mean lifespan of worms by over 33% compared to control. The average lifespan was prolonged by 15.3% and 18.5% at 50 and 100 μg/mL HAE-Sc, respectively. The extract (1000 μg/mL) was able to reduce the death of C. elegans in the presence of heavy metals up to 65.9, 96.8% and 87% for Pb, Hg, and Cd, respectively. In summary, S. cordifolia shows potential protective effects in C. elegans against toxicity caused by heavy metals and heat.

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Section: Introductionmentioning

confidence: 99%