Neurotoxicology Testing

Raffaele, Kathleen C.; Weisenburger, Walter P.

doi:10.1201/b14280-13

Cited by 1 publication

(2 citation statements)

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“…These tests are normally used in behavioral toxicology to assess adverse effects of chemicals on the nervous system upon adult or developmental exposure to chemicals [29]. The lack of differences between Gclm −/− and wild-type mice in these tests would suggest that GSH deficiency does not lead to alterations in nervous system function significant enough to be detected.…”

Section: Discussionmentioning

confidence: 99%

“…Results of the present study indicate that Gclm −/− mice did not differ from wild-type mice in a number of behaviors aimed at testing spontaneous motor activity, motor coordination, learning and memory, and sensory functions. These tests are normally used in behavioral toxicology to assess adverse effects of chemicals on the nervous system upon adult or developmental exposure to chemicals [ 29 ]. The lack of differences between Gclm −/− and wild-type mice in these tests would suggest that GSH deficiency does not lead to alterations in nervous system function significant enough to be detected.…”

Section: Discussionmentioning

confidence: 99%

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Behavioral Characterization ofGCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative Stress

Cole

Giordano

et al. 2011

Journal of Toxicology

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Glutathione (GSH) is a major player in cellular defense against oxidative stress. Deletion of the modifier subunit of glutamate cysteine ligase (GCLM), the first and the rate-limiting enzyme in the synthesis of GSH, leads to significantly lower GSH levels in all tissues including the brain. GCLM-knockout (Gclm−/−) mice may thus represent a model for compromised response to oxidative stress amenable to in vitro and in vivo investigations. In order to determine whether the diminished GSH content would by itself cause behavioral alterations, a series of behavioral tests were carried out comparing young adult Gclm−/− with wild-type mice. Tests included the rotarod, acoustic startle reflex and prepulse inhibition of the startle reflex, open field behavior, and the platform reversal variant of the Morris Water Maze. Results showed no differences between Gclm−/− and wild-type mice in any of the neurobehavioral tests. However, more subtle alterations, or changes which may appear as animals age, cannot be excluded.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%