Neurotrophic factors and Alzheimer’s disease: are we focusing on the wrong molecule?

Fahnestock, Margaret; Garzon, Diego J.; Holsinger, R. M. Damian; Michalski, Bernadeta

doi:10.1007/978-3-7091-6139-5_22

Cited by 115 publications

(92 citation statements)

References 43 publications

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“…BDNF has been shown to exert beneficial effects on synaptic plasticity and may facilitate learning and memory. It has been reported that AD may be caused or exacerbated by low levels of BDNF in the basal forebrain (5). Therefore, to determine whether ET alone, LA alone or COMA had any effect on synaptic plasticity, spatial learning and memory in the brains of APPsw Tg mice, the expression level of BDNF was estimated by Western blot analysis.…”

Section: Preventative Effects Of Exercise Training and ·-Lipoic Acid mentioning

confidence: 99%

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

Cho¹

2010

Int J Mol Med

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Abstract. Exercise training was suggested as a practical therapeutic strategy for human subjects suffering from Alzheimer's disease (AD) in our previous study. Therefore, the purpose of this study was to investigate the effects of combining exercise training with the administration of antioxidants on the pathological phenotype of AD. To accomplish this, non-transgenic mice (Non-Tg) and NSE/ APPsw Tg mice were treated with ·-lipoic acid and treadmill exercised for 16 weeks, after which their brains were evaluated to determine whether any changes in the pathological phenotype-related factors occurred. The results indicated that (i) the combination-applied (COMA) Tg group with exercise training (ET) and ·-lipoic acid administration (LA) showed ameliorated spatial learning and memory compared to the sedentary (SED)-Tg and single-treatment groups; (ii) there were no differences in the level of Aß-42 peptides across groups; (iii) the level of glucose transporter-1 and brain-derived neurotrophic factor proteins were highly increased in the COMA group, (iv) ET and LA did not induce a synergistic effect on the expression of heat shock protein-70 and apoptotic proteins including Bax and caspase-3; (v) the levels of SOD-1 and CAT suppressing oxidative stress were extensively higher in the COMA than in the singletreated groups and (vi) there were no significant differences across groups regarding these serum characteristics, although these levels were lower than the SED-Tg group. Taken together, these results suggest that the combination with ET and LA may contribute to protect the neuron injury induced by Aß peptides and may be considered an effective therapeutic strategy for human subjects suffering from AD.

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Section: Preventative Effects Of Exercise Training and ·-Lipoic Acid mentioning

confidence: 99%

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

Cho¹

2010

Int J Mol Med

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“…As suggested by many investigators, estrogen and neurotrophins such as NGF and BDNF may be relevant to the etiology of Alzheimer's disease (AD; [119,120]). Clinical studies have shown that reduced BDNF may be an early marker of the disease, since both proBDNF and BDNF decline prior to the end stages of AD.…”

Section: Implications For Neurological and Psychiatric Disease A mentioning

confidence: 99%

Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS

Scharfman

MacLusky

2006

Frontiers in Neuroendocrinology

270

202

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In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and mechanisms of action. The demonstration of an estrogen-sensitive response element on the BDNF gene provided an impetus to explore a direct relationship between estrogen and BDNF, and predicted that the effects of estrogen, at least in part, might be due to the induction of BDNF. This hypothesis is discussed with respect to the hippocampus, where substantial evidence has accumulated in favor of it, but alternate hypotheses are also raised. It is suggested that some of the interactions between estrogen and BDNF, as well as the controversies and implications associated with their respective actions, may be best appreciated in light of the ability of BDNF to induce neuropeptide Y (NPY) synthesis in hippocampal neurons. Taken together, this tri-molecular cascade, estrogen-BDNF-NPY, may be important in understanding the hormonal regulation of hippocampal function. It may also be relevant to other regions of the CNS where estrogen is known to exert profound effects, such as amygdala and hypothalamus; and may provide greater insight into neurological disorders and psychiatric illness, including Alzheimer's disease, depression and epilepsy.

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“…It was also suggested that there might be an association between attenuated BDNF gene expression and the development of neurofibrillary tangles and senile plaques [9,10]. A BDNF gene polymorphism 196 A/G; (dbSNP number: rs6265) results in an addition of a misallocated valine amino acid instead of methionine at the 66 th position of the amino acid sequence of polypeptide that may eventually lead to changes in intracellular protein synthesis [11].…”

Section: Methodsmentioning

confidence: 99%

Brain Derived Neurotropic Factor Gene Val66Met Polymorphism in Alzheimer’s Patients in Northern Turkey

Solmaz¹,

Sümbül²,

Rüstemoğlu³

et al. 2017

J Neurol Exp Neurosci

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Neurotrophic factors and Alzheimer’s disease: are we focusing on the wrong molecule?

Cited by 115 publications

References 43 publications

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS

Brain Derived Neurotropic Factor Gene Val66Met Polymorphism in Alzheimer’s Patients in Northern Turkey

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