Neurotrophin-4 is required for tolerance to morphine in the mouse

Smith, Desmond J.; Leil, Tarek A.; Liu, Xin

doi:10.1016/s0304-3940(03)00084-3

Cited by 26 publications

(25 citation statements)

References 16 publications

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“…It is well-known that the signal peptide is located at the terminal of amino acid sequence of a secreted protein and plays an important role in protein targeting and translocation in both prokaryotic and eukaryotic cells. NT4 is a member of the neurotrophin family, involved in controlling survival and differentiation of vertebrate neurons [16] . Besides the common features of neurotrophins, NT4 has many unusual features.…”

Section: Discussionmentioning

confidence: 99%

NT4(Si)-p53(N15)-antennapedia induces cell death in ahuman hepatocellular carcinoma cell line

Song¹,

Liu²,

Wang³

et al. 2009

WJG

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Section: Discussionmentioning

confidence: 99%

NT4(Si)-p53(N15)-antennapedia induces cell death in ahuman hepatocellular carcinoma cell line

Song¹,

Liu²,

Wang³

et al. 2009

WJG

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“…It has been reported that mice lacking NT-4 display substantially reduced tolerance to morphine compared to wild-type mice. Since NT-4 knockout mice also show abnormalities in long-term but not short-term memory, common molecular pathways for some of the enduring changes of drug addiction and memory consolidation have been suggested [1] . NT-4 enhances glutamatergic synaptic transmission in cultured hippocampal neurons [22] .…”

Section: Discussionmentioning

confidence: 99%

“…Opioids are the most efficacious and commonly used analgesics in the management of pain; however, their long-term administration results in the development of tolerance to their analgesic effects, limiting their clinical usefulness in pain management [1] . Although opioid tolerance is complex and incompletely understood, it has been proposed that opioid tolerance is a model of neuronal plasticity similar to learning and memory [1] .…”

Section: Introductionmentioning

confidence: 99%

“…Although opioid tolerance is complex and incompletely understood, it has been proposed that opioid tolerance is a model of neuronal plasticity similar to learning and memory [1] . Recent evidence suggests that neurotrophins in addition to their well-known roles in the survival, differentiation and maintenance of function of different peripheral and cen-…”

Section: Introductionmentioning

confidence: 99%

“…It is shown that loss of the NT-4 gene results in deficits in one long-lasting aspect of opiate addiction, namely tolerance. It has been suggested that NT-4 is required for the synaptic plasticity mediating both addiction and memory [1] . Also there are lines of evidence indicating that NMDA receptors are involved in the neural plasticity underlying the development of opiate tolerance, sensitization and physical dependence [7,8] .…”

Section: Introductionmentioning

confidence: 99%

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Additive Effect of Dextromethorphan on the Inhibitory Effect of Anti-NT4 on Morphine Tolerance

Hatami¹,

Oryan²,

Semnanian

et al. 2006

Pharmacology

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It has been proposed that opioid tolerance is a model of neuronal plasticity similar to learning and memory. Recent evidence suggests that neurotrophins may be involved in synaptic development and plasticity. Observations indicate that neurotrophin 4 (NT4) is required for the synaptic plasticity mediating both tolerance and memory. Also there are lines of evidence to indicate that NMDA receptors are involved in the neural plasticity underlying the development of opiate tolerance. Neurotrophins affect central transmission postsynaptically by enhancing NMDA receptor responsiveness. So we used the clinically available NMDA receptor antagonist, dextromethorphan, and the neurotrophin 4 antibody, anti-NT4, concomitantly and alone to investigate their effects on morphine tolerance. Tolerance was induced by injecting morphine (7 and 10 mg/kg i.p.) once per day for 4 days. Anti-NT4 (1 µg/rat i.c.v.) was administered 15 min before morphine. Results showed that chronic concomitant treatment of anti-NT4 with morphine in both doses inhibited the development of morphine tolerance. Also acute treatment of anti-NT4 significantly reversed the tolerance that was induced by morphine 7 mg/kg but failed to reverse the tolerance of morphine 10 mg/kg. Dextromethorphan in both doses (10 or 30 mg/kg) has an additive effect on the inhibitory effect of anti-NT4 on the reversal of morphine tolerance (7 mg/kg). These findings provide additional support for the hypothesis that NMDA receptor and NT4 may be involved in neural plasticity underlying opiate tolerance.

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Neurotrophic Factors and Their Potential Applications in Tissue Regeneration

Xiao¹,

2015

Arch. Immunol. Ther. Exp.

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Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration. They have been studied as potential drug candidates for treating neurodegenerative diseases. Since their identification, there are more and more evidences to indicate that neurotrophic factors are also expressed in non-neuronal tissues and regulate the survival, anti-inflammation, proliferation and differentiation in these tissues. This mini review summarizes the characteristics of the neurotrophic factors and their potential clinical applications in the regeneration of neuronal and non-neuronal tissues.

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Neurotrophin-4 is required for tolerance to morphine in the mouse

Cited by 26 publications

References 16 publications

NT4(Si)-p53(N15)-antennapedia induces cell death in ahuman hepatocellular carcinoma cell line

NT4(Si)-p53(N15)-antennapedia induces cell death in ahuman hepatocellular carcinoma cell line

Additive Effect of Dextromethorphan on the Inhibitory Effect of Anti-NT4 on Morphine Tolerance

Neurotrophic Factors and Their Potential Applications in Tissue Regeneration

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