Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm

Estrogen receptor‐β of microglia underlies sexual differentiation of neuronal protection via ginsenosides in mice brain

“…BDNF is a member of the neurotrophin family that generally promotes neuronal survival. Brains with reduced levels of BDNF become vulnerable to neurodegenerative disorders such as Alzheimer's disease, Huntington's disease, and Parkinson's disease . Although previous reports indicated BDNF is an effective therapeutic substance against bacterial meningitis, the exact mechanism of its efficacy remains unclear .…”

Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection

“…Then, intracellular substrates such as PLCγ, PI3K, MEK/ERK can promote signal transduction (Josephy‐Hernandez et al . ). In rodents, alternative splicing of TrkB mRNA generates three different receptors: C‐terminal truncated isoforms of TrkB (TrkB‐T1 and T2), which lack intracellular tyrosine kinase activity, and full length TrkB catalytic receptor (TrkB‐FL) (Luberg et al .…”

Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain

“…Neurotrophins act through two distinct receptors: a high-affinity and selective receptor tyrosine kinase family called Trk (containing three members: TrkA, TrkB, and TrkC) and a low affinity receptor called p75, which is a member of the TNFα receptor superfamily [113]. Whereas each neurotrophin has a preferred Trk (NGF binds TrkA, BDNF and NT-4 bind TrkB, and NT-3 prefers TrkC but also binds TrkA and TrkB), all neurotrophins bind p75 with a similar affinity (usually low) [114]. Neurotrophins are initially synthesized as precursors or proneurotrophins.…”